1-Cyclopropylpiperazine
- Product Name
- 1-Cyclopropylpiperazine
- CAS No.
- 20327-23-5
- Chemical Name
- 1-Cyclopropylpiperazine
- Synonyms
- Cyclopropyl piperazine;N-cyclopropylpiperazine;1-Cyclopropylpiperazine;Piperazine,1-cyclopropyl-;1-Cyclopropylpiperazine >(Piperazin-1-yl)cyclopropane;1-(Cyclopropyl Phenyl)Piperazine;1-Cyclopropylpiperazine - [C14363];1-Cyclopropylpiperazine ISO 9001：2015 REACH
- CBNumber
- CB4947000
- Molecular Formula
- C7H14N2
- Formula Weight
- 126.2
- MOL File
- 20327-23-5.mol
1-Cyclopropylpiperazine Property
- Boiling point:
- 43°C/7mm
- Density
- 0.94
- refractive index
- 1.4804
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- clear liquid
- pka
- 9.23±0.10(Predicted)
- color
- Colorless to Light yellow
- InChI
- InChI=1S/C7H14N2/c1-2-7(1)9-5-3-8-4-6-9/h7-8H,1-6H2
- InChIKey
- HNZJIWIXRPBFAN-UHFFFAOYSA-N
- SMILES
- N1(C2CC2)CCNCC1
Safety
- Hazard Codes
- Xi
- RIDADR
- 3267
- HazardClass
- 8
- PackingGroup
- Ⅲ
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H227Combustible liquid
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C2794
- Product name
- 1-Cyclopropylpiperazine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $154
- Updated
- 2025/07/31
- Product number
- C986860
- Product name
- 1-Cyclopropylpiperazine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 3H32-1-U6
- Product name
- 1-Cyclopropylpiperazine
- Packaging
- 1g
- Price
- $77
- Updated
- 2021/12/16
- Product number
- FC75911
- Product name
- 1-Cyclopropylpiperazine
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FC75911
- Product name
- 1-Cyclopropylpiperazine
- Packaging
- 500mg
- Price
- $125
- Updated
- 2021/12/16
1-Cyclopropylpiperazine Chemical Properties,Usage,Production
Uses
1-cyclopropylpiperazine is a piperazine derivative known in the literature by synonyms such as N-cyclopropylpiperazine and 4-cyclopropylpiperazine. It has been used in the preparation of some tri- and tetrasubstituted ureas with histamine H3 antagonist receptor activity, 3-amido-4- anilinoquinolines series as CSF-1R kinase inhibitors, for the synthesis of cyclopropyl amines as modulators of the histamine H3 receptor, sulfonamide compounds as cysteine protease inhibitors, N-oxides as antibacterial agents and in the treatment of the disease caused by helicobacter infection[1].
Synthesis
77278-34-3
20327-23-5
Tert-butyl 4-cyclopropylpiperazine-1-carboxylate (0.792 g, 3.50 mmol) was used as a raw material, which was dissolved in a 1,4-dioxane solution (4.37 mL, 17.50 mmol) in 4 M HCl. The reaction mixture was stirred at room temperature for 3 hours under nitrogen protection. Upon completion of the reaction, the mixture was filtered and washed with ether to afford the crude product 1-cyclopropylpiperazine (0.659 g) as a white solid. Subsequently, the crude product was purified by ion exchange chromatography through SCX column. The target compound 1-cyclopropylpiperazine was eluted from the column using 3.5 M NH3/MeOH solution, and the pure grades were collected and evaporated to dryness to give the final 1-cyclopropylpiperazine (0.264 g, 59.7% yield) as a yellow oil. The structure of the product was confirmed by 1H NMR (399.9 MHz, DMSO-d6) with chemical shifts δ 0.25-0.30 (2H, m), 0.35-0.40 (2H, m), 1.54-1.60 (1H, m), 2.43 (4H, t), 2.60-2.65 (4H, t), 3.30 (1H, s).
References
[1] G. Ke?an. “DFT, FT-Raman, and FT-IR investigations of 1-cyclopropylpiperazine.” Journal of Structural Chemistry 54 6 (2014): 1044–1054.
1-Cyclopropylpiperazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Cyclopropylpiperazine manufacturers
- Product
- 1-Cyclopropylpiperazine 20327-23-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-08
- Product
- 1-Cyclopropylpiperazine 20327-23-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-24
- Product
- 1-Cyclopropylpiperazine 20327-23-5
- Price
- US $3.00/ASSAYS
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09