Description Pharmacodynamics Features Side effects
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Dienogestrel

Description Pharmacodynamics Features Side effects
Product Name
Dienogestrel
CAS No.
65928-58-7
Chemical Name
Dienogestrel
Synonyms
MJR-35;STS 557;ienoges;M 18575;Visanne;Dinagest;Dinogest;ZK 37659;Dienogest;Ene, with
CBNumber
CB4947237
Molecular Formula
C20H25NO2
Formula Weight
311.43
MOL File
65928-58-7.mol
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Dienogestrel Property

Melting point:
210-2140C
alpha 
D25 -290° (c = 0.5 in pyridine)
Boiling point:
451.46°C (rough estimate)
Density 
1.0899 (rough estimate)
refractive index 
1.5614 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Pyridine (Slightly)
pka
13?+-.0.40(Predicted)
form 
powder
color 
white to beige
optical activity
[α]/D -305 to -325°, c = 1 in dichloromethane
Merck 
14,3106
InChI
InChI=1/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/s3
InChIKey
AZFLJNIPTRTECV-XAYGXGNENA-N
SMILES
C[C@]12CCC3=C4CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)CC#N |&1:1,14,16,20,r|
CAS DataBase Reference
65928-58-7(CAS DataBase Reference)
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Safety

RTECS 
RC8899500
HS Code 
2937.23.5050
Toxicity
LD50 oral in mouse: 4gm/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1468
Product name
Dienogest
Purity
≥98% (HPLC)
Packaging
10MG
Price
$105
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1468
Product name
Dienogest
Purity
≥98% (HPLC)
Packaging
50MG
Price
$339
Updated
2023/06/20
TCI Chemical
Product number
D5230
Product name
Dienogest
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$171
Updated
2024/03/01
TCI Chemical
Product number
D5230
Product name
Dienogest
Purity
>98.0%(HPLC)
Packaging
250mg
Price
$597
Updated
2024/03/01
Cayman Chemical
Product number
21257
Product name
Dienogest
Purity
≥98%
Packaging
10mg
Price
$87
Updated
2024/03/01
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Dienogestrel Chemical Properties,Usage,Production

Description

Dienoest is a selective progesterone drug that has been launched in recent years. It can stabilize endometrial tissue by specifically binding to ethylene nortestosterone and progesterone derivatives. Studies have found that tumor necrosis factor (TNF) and interleukin (IL-8) tend to increase in patients with endometriosis.

Pharmacodynamics

Dienogest has progestogenic activity, possibly some antiprogestogenic activity, and has antiandrogenic activity.The medication does not interact with the estrogen receptor, the glucocorticoid receptor, or the mineralocorticoid receptor, and hence has no estrogenic, glucocorticoid, or antimineralocorticoid activity.Because of its relatively high selectivity as a progestogen, dienogest may have favorable safety and tolerability compared to various other progestins.

Features

Dienogest is a mixed progestogen with dual properties of 19-nortestosterone derivatives and progesterone derivatives; therefore, it combines the pharmacological advantages of natural and synthetic progestins with high progestogenic activity .

Side effects

Side effects associated with dienogestrel are the same as those expected of a progestogen.They include menstrual irregularities, headaches, nausea, breast tenderness, depression, acne, weight gain, flatulence, and others.Dienogest produces no androgenic side effects and has little effect on metabolic and lipid hemostatic parameters.

Physical properties

Dienogestrel is a pale yellow solid.

Uses

Derivative of 19-Nortestosterone. In combination with estrogen as oral contraceptive. Progestogen.

Uses

Dienogest is an orally active synthetic progesterone (or progestin). It is available for use as an oral contraceptive in combination with ethinylestradiol. It has antiandrogenic activity and as a result can improve androgenic symptoms.

Definition

ChEBI: A steroid hormone that is 17beta-hydroxy-3-oxoestra-4,9-diene substituted at position 17 by a cyanomethyl group. Used as an oral contraceptive.

brand name

Endometrion (Schering A.G., Germany).

Biochem/physiol Actions

Dienogest is used to treat endometriosis. It might also help to decrease the levels of plasma estradiol by stimulating cell death of granulosa cells in the ovary.

Dienogestrel Preparation Products And Raw materials

Raw materials

Preparation Products

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Dienogestrel Suppliers

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View Lastest Price from Dienogestrel manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Dienogestrel 65928-58-7
Price
US $0.00/g
Min. Order
10g
Purity
99%min
Supply Ability
10kg/month
Release date
2021-06-19
shandong perfect biotechnology co.ltd
Product
Dienogest 65928-58-7
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
1kg
Release date
2023-08-03
Wuhan Haorong Biotechnology Co.,Ltd
Product
Dienogestrel 65928-58-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000
Release date
2023-07-27

65928-58-7, Dienogestrel Related Search:

Dienogest Impurity I (17α)-3,3-[1,2-Ethanediylbis(oxy)]-17-hydroxy-19-norpregna-5(10),9(11)-diene-21-nitrile DiMethoxy Dienogest 9,11-Dehydro-17α-cyanoMethyl Estradiol Sts 64 (17α)-17-Hydroxy-3-oxo-19-norpregna-5(10),9(11)-diene-21-nitrile 3,3-DiMethoxyestra-5(10),9(11)-dien-17-one 17 alpha-cyanomethyl-19-nortestosterone (17α)-4-Bromo-17-hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile Estra-4,9-diene-3,17-dione 19-HYDROXY-4-ANDROSTENE-3,17-DIONE Estradiene dione-3-keta 17β-Cyanmethyl-oestra-1,3,5(10)-trien-3,17β-diol 11β-Hydroperoxy Dienogest Dodecanenitrile N-HEPTADECANONITRILE 3-HYDROXY-3-METHYLBUTYRONITRILE ORANILE

  • (17a)-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile
  • 17a-Cyanomethyl-17-hydroxyestra-4, 9-dien-3-one
  • Dienogestril
  • Endometrion
  • STS 557
  • Dienogestrel
  • Dienogest
  • (17R)-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile
  • 17α-Cyanomethyl-17β-hydroxyestra-4,9-dien-3-one
  • (17α)-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile
  • 17a-CyanoMethyl-17b-hydroxyestra-4, 9-dien-3-one
  • Dinagest
  • 2-((8S,13S,14S,17R)-17-hydroxy-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)acetonitrile
  • Contraceptive (oral)
  • STS 557;STS557;STS-557
  • 3-(4-methoxyphenyl)-2-sulfanylidene-5,6,7,8-tetrahydro-1H-[1]benzothiolo[2,3-d]pyrimidin-4-one
  • Dienogest (steroid)
  • Dienogest for system suitability CRS
  • Dienogest CRS
  • 19-Norpregna-4,9-diene-21-nitrile, 17-hydroxy-3-oxo-, (17α)-
  • Dienogest,Dienogestrel ,Dienogestril
  • Ene, with
  • 17alpha-17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile
  • 17-Hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile
  • DIENOGEST CAS NO.:65928-58-9
  • Dienogestrel USP/EP/BP
  • Dinogestrin
  • Dienogest (STS-557)
  • Dienogest for system suitability (Y0001782)
  • 17α-Cyanomethyl-17β-hydroxyestra-4,9-dien-3-one
  • Dinogest
  • 19-Norpregna-4,9-diene-21-nitrile, 17-hydroxy-3-oxo-, (17α)-
  • ienoges
  • Dienogest Impurity
  • Dinogestrel
  • 4, 9-ESTRADIENE-17α-CYANOMETHYL-17β-OL-3-ONE
  • BAY 86-5258
  • BAY-86-5258
  • BAY86-5258
  • M 18575
  • MJR-35
  • Visanne
  • ZK 37659
  • Dienogestrel Impurity
  • 65928-58-7
  • 65928-58-9
  • Inhibitors
  • Natazia
  • Final material
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
  • 65928-58-7