ChemicalBook > CAS DataBase List > Dienogestrel
Dienogestrel
Description Pharmacodynamics Features Side effects- Product Name
- Dienogestrel
- CAS No.
- 65928-58-7
- Chemical Name
- Dienogestrel
- Synonyms
- MJR-35;STS 557;ienoges;M 18575;Visanne;Dinagest;Dinogest;ZK 37659;Dienogest;Ene, with
- CBNumber
- CB4947237
- Molecular Formula
- C20H25NO2
- Formula Weight
- 311.43
- MOL File
- 65928-58-7.mol
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Dienogestrel Property
- Melting point:
- 210-2140C
- alpha
- D25 -290° (c = 0.5 in pyridine)
- Boiling point:
- 451.46°C (rough estimate)
- Density
- 1.0899 (rough estimate)
- refractive index
- 1.5614 (estimate)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Pyridine (Slightly)
- pka
- 13?+-.0.40(Predicted)
- form
- powder
- color
- white to beige
- optical activity
- [α]/D -305 to -325°, c = 1 in dichloromethane
- Merck
- 14,3106
- InChI
- InChI=1/C20H25NO2/c1-19-8-6-16-15-5-3-14(22)12-13(15)2-4-17(16)18(19)7-9-20(19,23)10-11-21/h12,17-18,23H,2-10H2,1H3/t17-,18+,19+,20-/s3
- InChIKey
- AZFLJNIPTRTECV-XAYGXGNENA-N
- SMILES
- C[C@]12CCC3=C4CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)CC#N |&1:1,14,16,20,r|
- CAS DataBase Reference
- 65928-58-7(CAS DataBase Reference)
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Safety
- RTECS
- RC8899500
- HS Code
- 2937.23.5050
- Toxicity
- LD50 oral in mouse: 4gm/kg
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML1468
- Product name
- Dienogest
- Purity
- ≥98% (HPLC)
- Packaging
- 10MG
- Price
- $105
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- SML1468
- Product name
- Dienogest
- Purity
- ≥98% (HPLC)
- Packaging
- 50MG
- Price
- $339
- Updated
- 2023/06/20
TCI Chemical
- Product number
- D5230
- Product name
- Dienogest
- Purity
- >98.0%(HPLC)
- Packaging
- 50mg
- Price
- $171
- Updated
- 2024/03/01
TCI Chemical
- Product number
- D5230
- Product name
- Dienogest
- Purity
- >98.0%(HPLC)
- Packaging
- 250mg
- Price
- $597
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21257
- Product name
- Dienogest
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $87
- Updated
- 2024/03/01
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Dienogestrel Chemical Properties,Usage,Production
Description
Dienoest is a selective progesterone drug that has been launched in recent years. It can stabilize endometrial tissue by specifically binding to ethylene nortestosterone and progesterone derivatives. Studies have found that tumor necrosis factor (TNF) and interleukin (IL-8) tend to increase in patients with endometriosis.
Pharmacodynamics
Dienogest has progestogenic activity, possibly some antiprogestogenic activity, and has antiandrogenic activity.The medication does not interact with the estrogen receptor, the glucocorticoid receptor, or the mineralocorticoid receptor, and hence has no estrogenic, glucocorticoid, or antimineralocorticoid activity.Because of its relatively high selectivity as a progestogen, dienogest may have favorable safety and tolerability compared to various other progestins.
Features
Dienogest is a mixed progestogen with dual properties of 19-nortestosterone derivatives and progesterone derivatives; therefore, it combines the pharmacological advantages of natural and synthetic progestins with high progestogenic activity .
Side effects
Side effects associated with dienogestrel are the same as those expected of a progestogen.They include menstrual irregularities, headaches, nausea, breast tenderness, depression, acne, weight gain, flatulence, and others.Dienogest produces no androgenic side effects and has little effect on metabolic and lipid hemostatic parameters.
Physical properties
Dienogestrel is a pale yellow solid.
Uses
Derivative of 19-Nortestosterone. In combination with estrogen as oral contraceptive. Progestogen.
Uses
Dienogest is an orally active synthetic progesterone (or progestin). It is available for use as an oral contraceptive in combination with ethinylestradiol. It has antiandrogenic activity and as a result can improve androgenic symptoms.
Definition
ChEBI: A steroid hormone that is 17beta-hydroxy-3-oxoestra-4,9-diene substituted at position 17 by a cyanomethyl group. Used as an oral contraceptive.
brand name
Endometrion (Schering A.G., Germany).
Biochem/physiol Actions
Dienogest is used to treat endometriosis. It might also help to decrease the levels of plasma estradiol by stimulating cell death of granulosa cells in the ovary.
Dienogestrel Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Dienogestrel manufacturers
Hebei Kangcang new material Technology Co., LTD
- Product
- Dienogest 65928-58-7
- Price
- US $20.00-10.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 20
- Release date
- 2024-03-20
Hebei Kangcang new material Technology Co., LTD
- Product
- Dienogest 65928-58-7
- Price
- US $9.00-60.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2024-03-22
Wuhan Haorong Biotechnology Co.,Ltd
- Product
- Dienogestrel 65928-58-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2023-07-27
65928-58-7, Dienogestrel Related Search:
Dienogest Impurity I
(17α)-3,3-[1,2-Ethanediylbis(oxy)]-17-hydroxy-19-norpregna-5(10),9(11)-diene-21-nitrile
DiMethoxy Dienogest
9,11-Dehydro-17α-cyanoMethyl Estradiol
Sts 64
(17α)-17-Hydroxy-3-oxo-19-norpregna-5(10),9(11)-diene-21-nitrile
3,3-DiMethoxyestra-5(10),9(11)-dien-17-one
17 alpha-cyanomethyl-19-nortestosterone
(17α)-4-Bromo-17-hydroxy-3-oxo-19-norpregna-4,9-diene-21-nitrile
Estra-4,9-diene-3,17-dione
19-HYDROXY-4-ANDROSTENE-3,17-DIONE
Estradiene dione-3-keta
17β-Cyanmethyl-oestra-1,3,5(10)-trien-3,17β-diol
11β-Hydroperoxy Dienogest
Dodecanenitrile
N-HEPTADECANONITRILE
3-HYDROXY-3-METHYLBUTYRONITRILE
ORANILE