4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
- Product Name
- 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
- CAS No.
-
6837-93-0
- Chemical Name
- 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
- Synonyms
- NSC16168,NSC-16168;4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid;1-Amino-8-(4-methylphenylsulfonyloxy)naphthalene-3,6-disulfonic acid;4-amino-5-(4-methylphenyl)sulfonyloxynaphthalene-2,7-disulfonic acid;8-Amino-1-(4-methylphenylsulfonyloxy)-3,6-naphthalenedisulfonic acid;4-Amino-5-[[(4-methylphenyl)sulfonyl]oxy]-2,7-naphthalenedisulfonic acid;2,7-Naphthalenedisulfonic acid, 4-amino-5-[[(4-methylphenyl)sulfonyl]oxy]-
- CBNumber
- CB4968018
- Molecular Formula
- C17H15NO9S3
- Formula Weight
- 473.5
- MOL File
- 6837-93-0.mol
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid Property
- Density
- 1.5197 (rough estimate)
- refractive index
- 1.7000 (estimate)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 31.25 mg/mL (66.00 mM)
- form
- Solid
- pka
- -1.16±0.40(Predicted)
- color
- Off-white to gray
Hazard and Precautionary Statements (GHS)
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid Chemical Properties,Usage,Production
Biological Activity
NSC16168 is a specific ERCC1-XPF inhibitor with IC50 value of 0.42 μM. It inhibits DNA repair and enhances the efficacy of CDDP in cancer.
in vitro
NSC16168 (0-50 μM) potentiates cisplatin efficacy in cancer cells.
Cell Viability Assay.
< td class="col1"> Cell Line: | H460 cells. |
| Concentration: | 0-50 μM. |
| Incubation Time: | 2 h. |
| Result: | Potentiated cisplatin efficacy in cancer cells. |
table>
in vivo
NSC16168 (20 mg/kg, ip, twice daily) exhibits significant anti-tumor activity and potentiates cisplatin antitumor activity in H460 lung cancer xenografts.
< /b>
| Animal Model: | 2.5×10 6 H460 cells were injected sc in the right flank of each mouse.
|
| Dosage: | 20 mg/kg. |
| Administration: | IP, twice daily for 10 days. |
| Result: | The tumor growth was minimally affected by compound and the mice displayed no signs of distress or toxic side effects.
The combination treatment with 16168 and cisplatin inhibited H460 tumor growth, which was maintained for the duration of the compound injections. |
target
IC50: 0.42 μM (ERCC1-XPF).
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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6837-93-0, 4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acidRelated Search:
4-amino-5-(tosyloxy)naphthalene-2,7-disulfonic acid
1-Amino-8-(4-methylphenylsulfonyloxy)naphthalene-3,6-disulfonic acid
4-Amino-5-[[(4-methylphenyl)sulfonyl]oxy]-2,7-naphthalenedisulfonic acid
8-Amino-1-(4-methylphenylsulfonyloxy)-3,6-naphthalenedisulfonic acid
4-amino-5-(4-methylphenyl)sulfonyloxynaphthalene-2,7-disulfonic acid
2,7-Naphthalenedisulfonic acid, 4-amino-5-[[(4-methylphenyl)sulfonyl]oxy]-
NSC16168,NSC-16168
6837-93-0