3-Fluoro-4-iodophenol
Application- Product Name
- 3-Fluoro-4-iodophenol
- CAS No.
- 122927-84-8
- Chemical Name
- 3-Fluoro-4-iodophenol
- Synonyms
- 3-Floro-4-iodophenol;3-Fluoro-4-iodophenol;Phenol,3-fluoro-4-iodo-
- CBNumber
- CB4969222
- Molecular Formula
- C6H4FIO
- Formula Weight
- 238
- MOL File
- 122927-84-8.mol
3-Fluoro-4-iodophenol Property
- Boiling point:
- 269.5℃
- Density
- 2.085
- Flash point:
- 117℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 8.36±0.18(Predicted)
- Appearance
- Light brown to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- AK-84436
- Product name
- 3-Fluoro-4-iodophenol
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $58
- Updated
- 2021/12/16
- Product number
- 094873
- Product name
- 3-Fluoro-4-iodophenol
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $319
- Updated
- 2021/12/16
- Product number
- HCH0364970
- Product name
- 3-FLUORO-4-IODOPHENOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.53
- Updated
- 2021/12/16
- Product number
- 094873
- Product name
- 3-Fluoro-4-iodophenol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $706
- Updated
- 2021/12/16
- Product number
- 4424AA
- Product name
- 3-Fluoro-4-iodophenol
- Packaging
- 5g
- Price
- $710
- Updated
- 2021/12/16
3-Fluoro-4-iodophenol Chemical Properties,Usage,Production
Application
3-Fluoro-4-iodophenol can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical production processes.
Synthesis
399-95-1
122927-84-8
General procedure for the synthesis of 3-fluoro-4-iodophenol from 4-amino-3-fluorophenol: 4-amino-3-fluorophenol (5 g, 39.4 mmol) was suspended in 15 mL of water and H2SO4 (4.62 g), and the mixture was cooled to -5 °C in an ice-salt bath. A solution of sodium nitrite (2.71 g, 39.4 mmol) in 15 mL of water was added slowly and dropwise to the mixture, keeping the internal temperature below +2 °C. The resulting brown solution was continued to be stirred at -5°C for 15 min. Subsequently, a solution of potassium iodide (7.87 g, 47.2 mmol) in 30 mL of water was added slowly and dropwise. After addition, the reaction mixture was stirred at room temperature for 4 hours. After the reaction was completed, the reaction mixture was diluted with EtOAc. The organic layer was washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated to afford the target product 3-fluoro-4-iodophenol (5 g, 53.3% yield).
References
[1] Patent: US2016/347717, 2016, A1. Location in patent: Paragraph 0609; 0610
3-Fluoro-4-iodophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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