2-Amino-6-hydroxymethylpyrimidine
- Product Name
- 2-Amino-6-hydroxymethylpyrimidine
- CAS No.
- 2164-67-2
- Chemical Name
- 2-Amino-6-hydroxymethylpyrimidine
- Synonyms
- 2-Aminopyrimidine-4-methanol;2-Bromo-8-methoxybenzoicacid;4-Pyrimidinemethanol, 2-amino-;(2-aminopyrimidin-4-yl)methanol;(2-azanylpyrimidin-4-yl)methanol;2-Amino-6-hydroxymethylpyrimidine;4-Pyrimidinemethanol, 2-amino- (7CI,8CI);2-Amino-6-hydroxymethylpyrimidine ISO 9001：2015 REACH;ETHYL3-(CYANOMETHYL)-2-OXO-2,3-DIHYDRO-1H-BENZO[D]IMIDAZOLE-6-CARBOXYLATE
- CBNumber
- CB4969585
- Molecular Formula
- C5H7N3O
- Formula Weight
- 125.13
- MOL File
- 2164-67-2.mol
2-Amino-6-hydroxymethylpyrimidine Property
- Melting point:
- 145 °C
- Boiling point:
- 396.3±34.0 °C(Predicted)
- Density
- 1.360±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 13.34±0.10(Predicted)
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- FA142818
- Product name
- (2-Aminopyrimidin-4-yl)methanol
- Packaging
- 100mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- FA142818
- Product name
- (2-Aminopyrimidin-4-yl)methanol
- Packaging
- 250mg
- Price
- $112.5
- Updated
- 2021/12/16
- Product number
- FA142818
- Product name
- (2-Aminopyrimidin-4-yl)methanol
- Packaging
- 500mg
- Price
- $195
- Updated
- 2021/12/16
- Product number
- FA142818
- Product name
- (2-Aminopyrimidin-4-yl)methanol
- Packaging
- 1g
- Price
- $342
- Updated
- 2021/12/16
- Product number
- FA142818
- Product name
- (2-Aminopyrimidin-4-yl)methanol
- Packaging
- 2g
- Price
- $594
- Updated
- 2021/12/16
2-Amino-6-hydroxymethylpyrimidine Chemical Properties,Usage,Production
Synthesis
2164-66-1
2164-67-2
General procedure for the synthesis of 2-amino-4-hydroxymethylpyrimidine from methyl 2-aminopyrimidine-4-carboxylate: 2-amino-4-methoxycarbonylpyrimidine (3.0 g, 20 mmol) was suspended in a solvent mixture of ethanol (150 mL) and dichloromethane (20 mL), followed by addition of sodium borohydride (2.2 g, 59 mmol). The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, acetone (20 mL) was added slowly under cooling in an ice bath, followed by dropwise addition of 2M hydrochloric acid until no bubbles were produced. The pH of the reaction mixture was adjusted to 8 with saturated aqueous sodium bicarbonate and the precipitated solid was collected by filtration. The filtrate was concentrated under reduced pressure, suspended in 10% methanol-chloroform solution and filtered through silica gel (5.0 g). The filtrate was evaporated under reduced pressure and the residue was recrystallized from ethyl acetate to give 1.8 g of 2-amino-4-hydroxymethylpyrimidine as a light yellow solid (yield: 73%). The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ 4.30 (s, 2H), 5.35 (s, 1H), 6.48 (s, 2H), 6.65 (d, J = 4.9 Hz, 1H), 8.19 (d, J = 4.9 Hz, 1H).
References
[1] Patent: EP1864977, 2007, A1. Location in patent: Page/Page column 17
2-Amino-6-hydroxymethylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-6-hydroxymethylpyrimidine manufacturers
- Product
- 2-Amino-6-hydroxymethylpyrimidine 2164-67-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-08