3-Formyl-pyrrolidine-1-carboxylicacidbenzylester
- Product Name
- 3-Formyl-pyrrolidine-1-carboxylicacidbenzylester
- CAS No.
- 276872-86-7
- Chemical Name
- 3-Formyl-pyrrolidine-1-carboxylicacidbenzylester
- Synonyms
- 1-Cbz-3-formyl-pyrrolidine;benzyl 3-forMylpyrrolidine-1-carboxylate;BENZYL 3-FORMYL-1-PYRROLIDINECARBOXYLATE;1-N-Cbz-3-formyl-pyrrolidine, CAS 276872-86-7;3-FORMYL-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTE$;1-Benzyloxycarbonylpyrrolidine-3-carboxaldehyde, 97%;1-Pyrrolidinecarboxylic acid, 3-formyl-, phenylmethyl ester
- CBNumber
- CB4971971
- Molecular Formula
- C13H15NO3
- Formula Weight
- 233.26
- MOL File
- 276872-86-7.mol
3-Formyl-pyrrolidine-1-carboxylicacidbenzylester Property
- Boiling point:
- 369.6±42.0 °C(Predicted)
- Density
- 1.263±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- pka
- -2.49±0.40(Predicted)
- Appearance
- Colorless to light yellow Liquid
- Sensitive
- Air Sensitive
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B535343
- Product name
- Benzyl3-Formylpyrrolidine-1-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- Y3298
- Product name
- Benzyl3-formylpyrrolidine-1-carboxylate
- Packaging
- 1g
- Price
- $249
- Updated
- 2021/12/16
- Product number
- CHM0017890
- Product name
- 1-CBZ-PYRROLIDINE-3-CARBOXALDEHYDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $794.36
- Updated
- 2021/12/16
- Product number
- CHM0017890
- Product name
- 1-CBZ-PYRROLIDINE-3-CARBOXALDEHYDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1261.26
- Updated
- 2021/12/16
- Product number
- CM197352
- Product name
- Benzyl3-formylpyrrolidine-1-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $393
- Updated
- 2021/12/16
3-Formyl-pyrrolidine-1-carboxylicacidbenzylester Chemical Properties,Usage,Production
Synthesis
315718-05-9
276872-86-7
General procedure for the synthesis of 1-Cbz-3-pyrrolidinecarboxaldehyde from 1-Cbz-3-hydroxymethylpyrrolidine: To a solution of dichloromethane (5 mL) of oxalyl chloride (0.23 mL, 2.8 mmol) was added drop-wise dimethylsulfoxide (0.43 mL, 5.6 mmol) dissolved in dichloromethane (1 mL) at -75 °C and the reaction was stirred for 2 min. Subsequently, a solution of N-benzyloxycarbonyl-3-hydroxymethylpyrrolidine (0.56 g, 2.5 mmol) in dichloromethane (2 mL) was slowly added, and stirring was continued for 0.5 hr keeping the temperature at -75 °C. Upon completion of the reaction, triethylamine (1.8 mL, 12.8 mmol) was added and stirred at the same temperature for 5 minutes before slowly warming to room temperature. The reaction was quenched by the addition of water (10 mL) and the product was extracted with dichloromethane (100 mL). The organic phase was washed sequentially with water (100 mL) and saturated brine (100 mL) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane, 1:1, v/v) to afford the target product 1-Cbz-3-pyrrolidinecarboxaldehyde (0.46 g, 78% yield). The product was characterized by 1H NMR (200 MHz, CDCl3): δ 9.7 (s, 1H), 7.42-7.28 (m, 5H), 5.14 (s, 2H), 3.90-3.72 (m, 1H), 3.68-3.35 (m, 3H), 3.15-2.96 (m, 1H), 2.32-2.02 (m, 2H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 8, p. 2150 - 2155
[2] Patent: WO2005/26154, 2005, A1. Location in patent: Page/Page column 110
[3] Patent: WO2005/26165, 2005, A1. Location in patent: Page/Page column 137
3-Formyl-pyrrolidine-1-carboxylicacidbenzylester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Formyl-pyrrolidine-1-carboxylicacidbenzylester manufacturers
- Product
- Benzyl 3-formylpyrrolidine-1-carboxylate 276872-86-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-10-23