ChemicalBook > CAS DataBase List > N-BOC-2-AMINOPHENOL

N-BOC-2-AMINOPHENOL

Product Name: N-BOC-2-AMINOPHENOL
CAS No.: 186663-74-1
Chemical Name: N-BOC-2-AMINOPHENOL
Synonyms: N-Boc-2-aminophenol;tert-Butyl o-hydroxyphenylcarbamate;tert-butyl N-(2-hydroxyphenyl)carbamate;(3-oxo-1lambda3,2-benziodoxol-3-yl)acetate;Carbamic acid, N-(2-hydroxyphenyl)-, 1,1-dimethylethyl ester;Carbamic acid, (2-hydroxyphenyl)-, 1,1-dimethylethyl ester (9CI);2-Hydroxyphenyl carbamic acid tert-butyl ester, N-tert-Butoxycarbonyl-2-aminophenol
CBNumber: CB4972372
Molecular Formula: C11H15NO3
Formula Weight: 209.24
MOL File: 186663-74-1.mol

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N-BOC-2-AMINOPHENOL Property

Melting point:: 140-144 °C (lit.)
Boiling point:: 265.6±23.0 °C(Predicted)
Density: 1.182±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Chloroform, Ethyl Acetate, Methanol
form: Solid
pka: 9.74±0.35(Predicted)
color: White

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Safety

Hazard Codes: Xi
Risk Statements: 36/38-43
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 635960
Product name: N-Boc-2-aminophenol
Purity: 97%
Packaging: 5g
Price: $190.4
Updated: 2025/07/31

TRC

Product number: B620955
Product name: N-Boc-2-aminophenol
Packaging: 1g
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-0031385
Product name: tert-Butyl(2-hydroxyphenyl)carbamate
Purity: 99.94%
Packaging: 1g
Price: $39
Updated: 2021/12/16

AK Scientific

Product number: CS-0031385
Product name: tert-Butyl(2-hydroxyphenyl)carbamate
Packaging: 1g
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-0031385
Product name: tert-Butyl(2-hydroxyphenyl)carbamate
Purity: 99.94%
Packaging: 5g
Price: $127
Updated: 2021/12/16

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N-BOC-2-AMINOPHENOL Chemical Properties,Usage,Production

Uses

N-Boc-2-aminophenol is an Boc protected 2-Aminophenol (A618930), an isomer of 4-Aminophenol (A618920).

Synthesis

24424-99-5

95-55-6

186663-74-1

GENERAL PROCEDURE: Iron(III) trifluoromethanesulfonate (Fe(OTf)3, 1 mol%) was added to a mixture containing o-aminophenol (1 mmol) and di-tert-butyl dicarbonate (Boc2O, 1 mmol) at room temperature with simultaneous magnetic stirring. The reaction mixture was continuously stirred until the reaction was complete (monitored by thin layer chromatography, TLC). After completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc) and washed with water. The organic layer was separated and dried with anhydrous magnesium sulfate (MgSO4). Finally, the solvent was removed by distillation under vacuum to obtain high purity N-Boc-2-aminophenol.

References

[1] Tetrahedron Letters, 2006, vol. 47, # 7, p. 1087 - 1091
[2] Journal of Chemical Research, 2013, vol. 37, # 12, p. 757 - 760
[3] Asian Journal of Chemistry, 2017, vol. 29, # 6, p. 1313 - 1316
[4] Journal of Organic Chemistry, 2002, vol. 67, # 14, p. 4882 - 4892
[5] Comptes Rendus Chimie, 2010, vol. 13, # 5, p. 544 - 547

N-BOC-2-AMINOPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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186663-74-1, N-BOC-2-AMINOPHENOLRelated Search:

4-N-Boc-amino-3-methoxyphenylboronic acid 3-(BOC-AMINO)-4-HYDROXYBENZOIC ACID Carbamic acid, (4-bromo-2-methoxyphenyl)-, 1,1-dimethylethyl ester (9CI) BOC-2-AMINO-3,4,5-TRIMETHOXYBENZOIC ACID (2-METHOXYPHENYL)-CARBAMIC ACID, 1,1-DIMETHYL ETHYL ESTER 3-N-BOC-AMINO-2-HYDROXY-5-METHYL ACETOPHENONE N-T-BUTOXYCARBONYL-2-(TRIFLUOROMETHOXY)ANILINE Benzoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-4-methoxy- (9CI) (5-AMINO-2-METHOXY-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER BOC-4-AMINO-3-METHOXYBENZOIC ACID N-BOC-2-AMINOPHENOL TERT-BUTYL 8-HYDROXY-3,4-DIHYDROQUINOLINE-1(2H)-CARBOXYLATE BOC-2-AMINO-3-METHOXYBENZOIC ACID 4-(TERT-BUTOXYCARBONYLAMINO)-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER BOC-2-METHOXY-6-METHYLANILINE TERT-BUTYL 8-AMINO-2-METHYL-2H-BENZO[B][1,4]OXAZINE-4(3H)-CARBOXYLATE tert-Butyl 2-methyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-ylcarbamate N-BOC-(2-IODO-6-METHOXY-PHENYL)-METHYL-AMINE

Carbamic acid, (2-hydroxyphenyl)-, 1,1-dimethylethyl ester (9CI)

2-Hydroxyphenyl carbamic acid tert-butyl ester, N-tert-Butoxycarbonyl-2-aminophenol

tert-Butyl o-hydroxyphenylcarbamate

tert-butyl N-(2-hydroxyphenyl)carbamate

Carbamic acid, N-(2-hydroxyphenyl)-, 1,1-dimethylethyl ester

(3-oxo-1lambda3,2-benziodoxol-3-yl)acetate

<i>N</i>-Boc-2-aminophenol

186663-74-1

HOC6H4NHCO2CCH33

N-BOC