GUVACINE HYDROCHLORIDE

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GUVACINE HYDROCHLORIDE

Product Name: GUVACINE HYDROCHLORIDE
CAS No.: 6027-91-4
Chemical Name: GUVACINE HYDROCHLORIDE
Synonyms: 1,2,5,6-Tetrahydro-;GUVACINE HYDROCHLORIDE;Norareca alkaloid hydrochloride;GUVACINE HYDROCHLORIDE >96% \ GABA UPTAK;Guvacine hydrochloride >=97% (NMR), solid;1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Hydrochloride;3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride
CBNumber: CB4972615
Molecular Formula: C6H10ClNO2
Formula Weight: 163.6021
MOL File: 6027-91-4.mol

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GUVACINE HYDROCHLORIDE Property

Melting point:: 316 °C (decomp)
storage temp.: Inert atmosphere,Room Temperature
solubility: H2O: soluble
form: solid
color: white

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 23361
Product name: Guvacine (hydrochloride)
Purity: ≥95%
Packaging: 25mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 23361
Product name: Guvacine (hydrochloride)
Purity: ≥95%
Packaging: 50mg
Price: $101
Updated: 2024/03/01

Cayman Chemical

Product number: 23361
Product name: Guvacine (hydrochloride)
Purity: ≥95%
Packaging: 100mg
Price: $198
Updated: 2024/03/01

Cayman Chemical

Product number: 23361
Product name: Guvacine (hydrochloride)
Purity: ≥95%
Packaging: 250mg
Price: $437
Updated: 2024/03/01

TRC

Product number: G876400
Product name: Guvacine hydrochloride
Packaging: 100mg
Price: $200
Updated: 2021/12/16

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GUVACINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Beige Solid

Uses

Guvacine Hydrochloride is a GABA uptake inhibitor (hGABA T-1, rGABA T-2, hGABA T-3 and hBGT-1) (1,2,3). Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain (4). Guvacine Hydrochloride may be useful for treating neuropsychiatric disorders.

Uses

Guvacine Hydrochloride is a GABA uptake inhibitor and it is used for the treatment of neurodegenerative diseases.

Biological Activity

Guvacine hydrochloride is an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3).

in vitro

Guvacine hydrochloride is a potent inhibitor of GABA transporter, dispalys modest selectivity for cloned GABA transporters with IC50s of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). Guvacine has low affinity at hBGT-1 (IC50 >1 mM). Guvacine hydrochloride is a potent inhibitor of GABA uptake, but does not inhibit sodium-independent GABA binding, and is weak or inactive as a GABA receptor agonist. Guvacine inhibits the uptake GABA and β-alanine with IC50s of 23 ± 2 μM, 66 ± 11 μM in the Cat spinal cord, and 8 ± 1 μM, 123 ± 28 μM in the rat cerebral cortex, respectively.

GUVACINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GUVACINE HYDROCHLORIDE manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: GUVACINE HYDROCHLORIDE 6027-91-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-24

6027-91-4, GUVACINE HYDROCHLORIDERelated Search:

GUVACINE HYDROCHLORIDE

GUVACINE HYDROCHLORIDE >96% \ GABA UPTAK

1,2,5,6-Tetrahydro-

1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Hydrochloride

3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-, hydrochloride

Guvacine hydrochloride >=97% (NMR), solid

GUVACINE HYDROCHLORIDE

Norareca alkaloid hydrochloride

6027-91-4

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