Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-
- Product Name
- Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-
- CAS No.
- 551909-15-0
- Chemical Name
- Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-
- Synonyms
- RTICBM-189;Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]-;Brain,Inhibitor,RTICBM-189,inhibit,Cocaine,RTICBM 189,Allosteric,Penetrant,Cannabinoid Receptor,Seeking,CB1,RTICBM189,Behavior
- CBNumber
- CB510051912
- Molecular Formula
- C15H14Cl2N2O
- Formula Weight
- 309.19
- MOL File
- 551909-15-0.mol
Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Property
- Boiling point:
- 433.1±45.0 °C(Predicted)
- Density
- 1.330±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO : 100 mg/mL (323.43 mM; Need ultrasonic)
- form
- Solid
- pka
- 13.54±0.46(Predicted)
- color
- White to off-white
Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Chemical Properties,Usage,Production
Biological Activity
RTICBM-189 is a potent, brain-penetrant allosteric modulator of the cannabinoid type-1 (CB1) receptor with a pIC50 of 7.54 in Ca2+ mobilization assay. RTICBM-189 has pIC50s of 5.29 and 6.25 for hCB1 and mCB1, respectively. RTICBM-189 significantly and selectively attenuates the reinstatement of the cocaine-seeking behavior in rats[1]. RTICBM-189 (10 mg/kg; i.p.) significantly and selectively attenuates reinstatement of the cocaine-seeking behavior in rats[1].RTICBM-189 (10 mg/kg; i.p.) rapidly absorbs into systemic circulation, with peak plasma concentration (Cmax,plasma=288.4 ng/mL) observed at tmax,plasma of 0.4 h post-dose. Peak brain levels are also reached at tmax,brain of 0.4 h with a significantly higher Cmax,brain value of 594.6 ng/mL in the brain[1].
References
[1]. Nguyen T, et al. Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior [published online ahead of print, 2021 Dec 20]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01432.
Urea, N-(4-chlorophenyl)-N'-[2-(3-chlorophenyl)ethyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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