ALEGLITAZAR

Product Name: ALEGLITAZAR
CAS No.: 475479-34-6
Chemical Name: ALEGLITAZAR
Synonyms: R1439;R 1439;R-1439;RO0728804;RO-0728804;RO 0728804;ALEGLITAZAR;Unii-41T4oag59u;Aleglitazar, 10 mM in DMSO;R1439;RO0728804;R-1439;RO-0728804;R 1439;RO 0728804
CBNumber: CB51011727
Molecular Formula: C24H23NO5S
Formula Weight: 437.51
MOL File: 475479-34-6.mol

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ALEGLITAZAR Property

Melting point:: 146-147 °C
Boiling point:: 665.2±65.0 °C(Predicted)
Density: 1.290
storage temp.: Store at -20°C
solubility: DMSO: ≥ 50 mg/mL (114.28 mM); Water: < 0.1 mg/mL (insoluble)
pka: 3.54±0.46(Predicted)
form: Powder
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: BRS0001095
Product name: ALEGLITAZAR
Purity: 95.00%
Packaging: 5MG
Price: $559.9
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611764
Product name: Aleglitazar
Packaging: 10mg
Price: $598.4
Updated: 2021/12/16

ChemScene

Product number: CS-1134
Product name: Aleglitazar
Purity: 99.30%
Packaging: 5mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-1134
Product name: Aleglitazar
Purity: 99.30%
Packaging: 10mg
Price: $950
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611764
Product name: Aleglitazar
Packaging: 50mg
Price: $1203.6
Updated: 2021/12/16

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ALEGLITAZAR Chemical Properties,Usage,Production

Uses

Aleglitazar (R1439) is a potent dual PPARα/γ agonist, with IC50s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes[1].

in vivo

Aleglitazar (0.3-3.0 mg/kg; i.p.; daily; for 7 days) exerts beneficial effects on structural and functional outcomes of mild brain ischemia^[3].
Aleglitazar reduces key aspects of microglia activation including NO production, release of proinflammatory cytokines, migration, and phagocytosis^[3].
Aleglitazar attenuates inflammatory responses in post-ischemic brain^[3].

Animal Model:	Male 129S6/SvEv mice (24-30 g), middle cerebral artery occlusion (MCAo) models^[3]
Dosage:	0.3 mg/kg, 3.0 mg/kg
Administration:	Intraperitoneal injection, daily, for 7 days
Result:	Reduced the size of the ischemic lesion as assessed using NeuN immunohistochemistry on day 7.

target

PPAR

IC 50

PPARγ: 19 nM (IC₅₀); PPARα: 38 nM (IC₅₀)

References

[1] Bénardeau A, Benz J, Binggeli A, et al. Aleglitazar, a new, potent, and balanced dual PPARalpha/gamma agonist for the treatment of type II diabetes. Bioorg Med Chem Lett. 2009 May 1;19(9):2468-73. DOI:10.1016/j.bmcl.2009.03.036
[2] Yan Chen, et al. Aleglitazar, a dual peroxisome proliferator-activated receptor-α and -γ agonist, protects cardiomyocytes against the adverse effects of hyperglycaemia. Diab Vasc Dis Res. 2017 Mar; 14(2): 152–162. DOI:10.1177/1479164116679081
[3] Valérie Boujon, et al. Dual PPARα/γ agonist aleglitazar confers stroke protection in a model of mild focal brain ischemia in mice. J Mol Med (Berl). 2019; 97(8): 1127-1138. DOI:10.1007/s00109-019-01801-0

ALEGLITAZAR Preparation Products And Raw materials

Raw materials

Preparation Products

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ALEGLITAZAR Suppliers

China 41 United States 10 Global 51

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Shanghai Fuhe Chemistry Technology Co., Ltd.

Tel: 0086-21-67651709
Fax: 0086-21-67651705
Email: cfx759@hotmail.com
Country: China
ProdList: 410
Advantage: 57

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Shanghai Witofly Chemical Co.,Ltd

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Email: sales@witofly.com
Country: China
ProdList: 2864
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Jinan Mingya Medical Technology Co., Ltd.

Tel: 0531-85828981
Fax: +86-531-85806006
Email: 864598798@qq.com
Country: China
ProdList: 588
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

SPIRO PHARMA

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Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
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Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
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475479-34-6, ALEGLITAZARRelated Search:

ALEGLITAZAR

(S)-2-Methoxy-3-[4-[2-(5-methyl-2-phenyloxazol-4-yl)ethoxy]benzo[b]thiophen-7-yl]propionic acid

Unii-41T4oag59u

Benzo[b]thiophene-7-propanoicacid, a-Methoxy-4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]-,(aS)-

R 1439

R1439

R-1439

RO 0728804

RO0728804

RO-0728804

(S)-2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzo[b]thiophen-7-yl)propanoic acid

(2S)-2-Methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid

R1439;RO0728804;R-1439;RO-0728804;R 1439;RO 0728804

Benzo[b]thiophene-7-propanoic acid, α-methoxy-4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]-, (αS)-

Aleglitazar, 10 mM in DMSO

475479-34-6