INDOMETHACIN ESTER, N-HEPTYL-

Product Name: INDOMETHACIN ESTER, N-HEPTYL-
CAS No.: 282728-47-6
Chemical Name: INDOMETHACIN ESTER, N-HEPTYL-
Synonyms: INDOMETHACIN HEPTYL ESTER;PYBCHCVNKGZCOH-UHFFFAOYSA-N;INDOMETHACIN ESTER, N-HEPTYL-;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, heptyl ester;1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, 1-HEPTYL ESTER;1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER;1-(P-CHLOROBENZOYL)-5-METHOXY-3-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER
CBNumber: CB5105498
Molecular Formula: C26H30ClNO4
Formula Weight: 455.97
MOL File: Mol file

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INDOMETHACIN ESTER, N-HEPTYL- Property

Flash point:: -16 °C
storage temp.: −20°C
solubility: ≤17mg/ml in ethanol;17mg/ml in DMSO;17mg/ml in dimethyl formamide
form: methyl acetate solution

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Safety

Hazard Codes: F,Xi
Risk Statements: 11-36-66-67
Safety Statements: 16-26-29-33-36
RIDADR: UN 1231 3/PG 2
WGK Germany: 1
RTECS: AI9100000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 70271
Product name: Indomethacin heptyl ester
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 70271
Product name: Indomethacin heptyl ester
Purity: ≥98%
Packaging: 5mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 70271
Product name: Indomethacin heptyl ester
Purity: ≥98%
Packaging: 10mg
Price: $186
Updated: 2024/03/01

Cayman Chemical

Product number: 70271
Product name: Indomethacin heptyl ester
Purity: ≥98%
Packaging: 50mg
Price: $807
Updated: 2024/03/01

ApexBio Technology

Product number: C4718
Product name: Indomethacinheptylester
Packaging: 10mg(solution)
Price: $210
Updated: 2021/12/16

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INDOMETHACIN ESTER, N-HEPTYL- Chemical Properties,Usage,Production

Description

Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans. Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivatized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC₅₀ for indomethacin heptyl ester for the inhibition of human recombinant COX-2 is 0.04 μM, making it more than 1,700 times more potent as an inhibitor of COX-2 than COX-1. While indomethacin itself has an IC₅₀ of 0.05 μM for the inhibition of COX-2, it also inhibits COX-1 with a corresponding IC₅₀ of 0.67 μM.

Definition

ChEBI: Indomethacin heptyl ester is a N-acylindole.

References

[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.

INDOMETHACIN ESTER, N-HEPTYL- Preparation Products And Raw materials

Raw materials

Preparation Products

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INDOMETHACIN ESTER, N-HEPTYL- Suppliers

CHINA 20 Switzerland 1 United Kingdom 1 United States 6 Global 28

Guangzhou Isun Pharmaceutical Co., Ltd

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TargetMol Chemicals Inc.

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Email: marketing@targetmol.com
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MedBioPharmaceutical Technology Inc

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TargetMol Chemicals Inc.

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Email: marketing@tsbiochem.com
Country: China
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Suzhou Zhixin Biotechnology Co., Ltd.

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282728-47-6, INDOMETHACIN ESTER, N-HEPTYL-Related Search:

PYBCHCVNKGZCOH-UHFFFAOYSA-N

INDOMETHACIN ESTER, N-HEPTYL-

INDOMETHACIN HEPTYL ESTER

1-(P-CHLOROBENZOYL)-5-METHOXY-3-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER

1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER

1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, 1-HEPTYL ESTER

1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, heptyl ester

282728-47-6

Enzymes, Inhibitors, and Substrates

Cyclooxygenase (COX) Enzymes

Cyclooxygenase Inhibitors

Cell Signaling Enzymes

Application Index

Biochemicals and Reagents

BioChemical

Cyclooxygenase InhibitorsCancer Research

A to

Arachidonic Acid Cascade

Chemopreventive Agents

Cyclooxygenase (COX) Enzymes

CyclooxygenaseCell Signaling Enzymes

CyclooxygenaseEnzyme Inhibitors by Enzyme

Enzyme Inhibitors