INDOMETHACIN ESTER, N-HEPTYL-

Product Name: INDOMETHACIN ESTER, N-HEPTYL-
CAS No.: 282728-47-6
Chemical Name: INDOMETHACIN ESTER, N-HEPTYL-
Synonyms: INDOMETHACIN HEPTYL ESTER;PYBCHCVNKGZCOH-UHFFFAOYSA-N;INDOMETHACIN ESTER, N-HEPTYL-;Indomethacin heptyl ester, 10 mM in DMSO;1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, heptyl ester;1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, 1-HEPTYL ESTER;1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER;1-(P-CHLOROBENZOYL)-5-METHOXY-3-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER
CBNumber: CB5105498
Molecular Formula: C26H30ClNO4
Formula Weight: 455.97
MOL File: Mol file

More

Less

INDOMETHACIN ESTER, N-HEPTYL- Property

Flash point:: -16 °C
storage temp.: −20°C
solubility: ≤17mg/ml in ethanol;17mg/ml in DMSO;17mg/ml in dimethyl formamide
form: methyl acetate solution

More

Less

Safety

Hazard Codes: F,Xi
Risk Statements: 11-36-66-67
Safety Statements: 16-26-29-33-36
RIDADR: UN 1231 3/PG 2
WGK Germany: 1
RTECS: AI9100000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 70271
Product name: Indomethacin heptyl ester
Purity: ≥98%
Packaging: 1mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 70271
Product name: Indomethacin heptyl ester
Purity: ≥98%
Packaging: 5mg
Price: $107
Updated: 2024/03/01

Cayman Chemical

Product number: 70271
Product name: Indomethacin heptyl ester
Purity: ≥98%
Packaging: 10mg
Price: $186
Updated: 2024/03/01

Cayman Chemical

Product number: 70271
Product name: Indomethacin heptyl ester
Purity: ≥98%
Packaging: 50mg
Price: $807
Updated: 2024/03/01

AK Scientific

Product number: 7192CR
Product name: Indomethacinheptylester
Packaging: 1mg
Price: $125
Updated: 2021/12/16

More

Less

INDOMETHACIN ESTER, N-HEPTYL- Chemical Properties,Usage,Production

Description

Indomethacin is a potent but non-selective inhibitor of both COX-1 and COX-2 in sheep and humans. Structurally, indomethacin is a substituted indole acetic acid, wherein the carboxylate can be derivatized as an ester or amide. These derivatives show enhanced selectivity for the COX-2 isoform. For example, the IC₅₀ for indomethacin heptyl ester for the inhibition of human recombinant COX-2 is 0.04 μM, making it more than 1,700 times more potent as an inhibitor of COX-2 than COX-1. While indomethacin itself has an IC₅₀ of 0.05 μM for the inhibition of COX-2, it also inhibits COX-1 with a corresponding IC₅₀ of 0.67 μM.

Uses

Indomethacin heptyl ester is a selective COX-2 inhibitor with IC50 of 0.04 μM, exhibits anti-inflammatory activity[1].

Definition

ChEBI: Indomethacin heptyl ester is a N-acylindole.

References

[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.

INDOMETHACIN ESTER, N-HEPTYL- Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

INDOMETHACIN ESTER, N-HEPTYL- Suppliers

CHINA 27 Switzerland 1 United Kingdom 1 United States 6 Global 35

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

EMD Biosciences, Inc.

Tel: --
Fax: --
Email: technical@calbiochem.com
Country: United States
ProdList: 6529
Advantage: 66

282728-47-6, INDOMETHACIN ESTER, N-HEPTYL-Related Search:

PYBCHCVNKGZCOH-UHFFFAOYSA-N

INDOMETHACIN ESTER, N-HEPTYL-

INDOMETHACIN HEPTYL ESTER

1-(P-CHLOROBENZOYL)-5-METHOXY-3-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER

1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, N-HEPTYL ESTER

1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, 1-HEPTYL ESTER

1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, heptyl ester

Indomethacin heptyl ester, 10 mM in DMSO

282728-47-6

Enzymes, Inhibitors, and Substrates

Cyclooxygenase (COX) Enzymes

Cyclooxygenase Inhibitors

Cell Signaling Enzymes

Application Index

Biochemicals and Reagents

BioChemical

Cyclooxygenase InhibitorsCancer Research

A to

Arachidonic Acid Cascade

Chemopreventive Agents

Cyclooxygenase (COX) Enzymes

CyclooxygenaseCell Signaling Enzymes

CyclooxygenaseEnzyme Inhibitors by Enzyme

Enzyme Inhibitors