ChemicalBook > CAS DataBase List > Pyridine, 5-(bromomethyl)-2-chloro- (9CI)

Pyridine, 5-(bromomethyl)-2-chloro- (9CI)

Product Name
Pyridine, 5-(bromomethyl)-2-chloro- (9CI)
CAS No.
182924-36-3
Chemical Name
Pyridine, 5-(bromomethyl)-2-chloro- (9CI)
Synonyms
5-bromomethyl-2-chloropyridin;5-BROMOMETHYL-2-CHLOROPYRIDINE;6-Chloro-3-bromomethylpyridine;Pyridine, 5-(bromomethyl)-2-chloro-;Pyridine, 5-(bromomethyl)-2-chloro- (9CI);5-(bromomethyl)-2-chloropyridine hydrochloride;5-[methylene- 14C1] (bromomethyl)-2-chloropyridine;Pyridine, 5-(bromomethyl)-2-chloro- (9CI) ISO 9001：2015 REACH
CBNumber
CB51060710
Molecular Formula
C6H5BrClN
Formula Weight
206.47
MOL File
182924-36-3.mol
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Pyridine, 5-(bromomethyl)-2-chloro- (9CI) Property

Melting point:
48-50°C
Boiling point:
262.5±25.0 °C(Predicted)
Density 
1.663±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
-0.89±0.10(Predicted)
form 
Solid
color 
Pale Yellow
InChI
InChI=1S/C6H5BrClN/c7-3-5-1-2-6(8)9-4-5/h1-2,4H,3H2
InChIKey
YJOULMMJZAADRY-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=C(CBr)C=C1
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Safety

RIDADR 
1759
HazardClass 
8
PackingGroup 
Ⅲ
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
B697130
Product name
5-Bromomethyl-2-chloropyridine
Packaging
250mg
Price
$70
Updated
2021/12/16
TRC
Product number
B697130
Product name
5-Bromomethyl-2-chloropyridine
Packaging
25mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB147805
Product name
5-(Bromomethyl)-2-chloropyridine
Packaging
100mg
Price
$53
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0036704
Product name
5-BROMOMETHYL-2-CHLOROPYRIDINE
Purity
95.00%
Packaging
1G
Price
$1034.88
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0036704
Product name
5-BROMOMETHYL-2-CHLOROPYRIDINE
Purity
95.00%
Packaging
5G
Price
$2067.45
Updated
2021/12/16
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Pyridine, 5-(bromomethyl)-2-chloro- (9CI) Chemical Properties,Usage,Production

Uses

5-Bromomethyl-2-chloropyridine is a reagent used in the preparation of gonadotropin-releasing hormone receptor antagonist using uracil scaffold.

Synthesis

22536-61-4

182924-36-3

The general procedure for the synthesis of 5-bromomethyl-2-chloropyridine using 2-chloro-5-methylpyrimidine as starting material was as follows: synthetic embodiment 25, N-[1-((2-chloropyrimidin-5-yl)methyl)pyridin-2(1H)-ylidene]-2,2,2-trifluoroacetamide (compound 243). 2-Chloro-5-methylpyrimidine (1.04 g, 8.13 mmol) was dissolved in 30 mL of carbon tetrachloride and N-bromosuccinimide (1.73 g, 9.75 mmol) and benzoyl peroxide (20 mg) were added. The mixture was heated to reflux for 6 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature, concentrated under reduced pressure and purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 3:1) to afford 5-bromomethyl-2-chloropyridine 641 mg (38% yield).1H-NMR (CDCl3, δ, ppm): 4.42 (2H, s), 8.66 (2H, s).

References

[1] Patent: US2013/150414, 2013, A1. Location in patent: Paragraph 0437

Pyridine, 5-(bromomethyl)-2-chloro- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Pyridine, 5-(bromomethyl)-2-chloro- (9CI) manufacturers

Dideu Industries Group Limited
Product
Pyridine, 5-(bromomethyl)-2-chloro- (9CI) 182924-36-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-03
Career Henan Chemical Co
Product
Pyridine, 5-(bromomethyl)-2-chloro- (9CI) 182924-36-3
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
200KG
Release date
2018-12-23

182924-36-3, Pyridine, 5-(bromomethyl)-2-chloro- (9CI)Related Search:

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