Quinazoline, 4-methyl- (6CI,7CI,8CI,9CI)
- Product Name
- Quinazoline, 4-methyl- (6CI,7CI,8CI,9CI)
- CAS No.
- 700-46-9
- Chemical Name
- Quinazoline, 4-methyl- (6CI,7CI,8CI,9CI)
- Synonyms
- 4-Methylquinazoline;Quinazoline, 4-methyl-;Quinazoline, 4-methyl- (6CI,7CI,8CI,9CI)
- CBNumber
- CB51069773
- Molecular Formula
- C9H8N2
- Formula Weight
- 144.17
- MOL File
- 700-46-9.mol
Quinazoline, 4-methyl- (6CI,7CI,8CI,9CI) Property
- Melting point:
- 36-37 °C
- Boiling point:
- 260 °C
- Density
- 1.141±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 2.69±0.30(Predicted)
- Appearance
- Light yellow to yellow Solid-Liquid Mixture
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M321479
- Product name
- 4-Methylquinazoline
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- M321479
- Product name
- 4-Methylquinazoline
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CHM0362651
- Product name
- 4-METHYLQUINAZOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.73
- Updated
- 2021/12/16
- Product number
- A331983
- Product name
- 4-Methylquinazoline
- Purity
- 95%
- Packaging
- 5g
- Price
- $609
- Updated
- 2021/12/16
- Product number
- CM142684
- Product name
- 4-methylquinazoline
- Purity
- 95%
- Packaging
- 5g
- Price
- $879
- Updated
- 2021/12/16
Quinazoline, 4-methyl- (6CI,7CI,8CI,9CI) Chemical Properties,Usage,Production
Uses
4-Methylquinazoline is an abdominal sex pheromone in Jewel wasp and other animals.
Synthesis Reference(s)
Journal of the American Chemical Society, 73, p. 5777, 1951 DOI: 10.1021/ja01156a085
Synthesis
50-00-0
2142-69-0
700-46-9
GENERAL METHODS: 2'-Bromoacetophenone (1a) (100.0 mg, 0.5 mmol), benzaldehyde (2a) (58.0 mg, 0.55 mmol), CuCl (5.0 mg, 0.05 mmol), 25% ammonia (0.5 mL), and NMP (0.5 mL) were sequentially added to a 25 mL thick-walled Pyrex screw-capped tube, which was sealed under an atmosphere of air sealed under air atmosphere. The reaction mixture was placed in an oil bath at 80°C and stirred for 12 hours. After the reaction was completed, it was cooled to room temperature and the crude product was extracted with EtOAc three times (3.0 mL each time). The organic phases were combined and concentrated under reduced pressure to remove the solvent. The residue was dissolved with CH2Cl2 (4.0 mL) and n-docosane (62.1 mg, 0.2 mmol) was added as an internal standard for GC analysis. After analyzing the reaction mixture by GC and GC-MS, the volatile solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography [eluent: petroleum ether, followed by a mixed solvent of petroleum ether/ethyl acetate (100:1 to 50:1)] to afford 4-methyl-2-phenylquinazoline (3a) (69.6 mg, 0.32 mmol, 63% yield) as a white solid.GC analysis showed that the GC yield of 3a was 65%.
References
[1] Tetrahedron, 2012, vol. 68, # 46, p. 9364 - 9370
Quinazoline, 4-methyl- (6CI,7CI,8CI,9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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