Talinolol

Product Name: Talinolol
CAS No.: 57460-41-0
Chemical Name: Talinolol
Synonyms: Cordanum;rac-Talinolol ;Racemic talinolol;Talinolol, 10 mM in DMSO;1-(4-(Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol;1-(4-Cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane;1-(3-(3-Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol;1-(4-(3-(tert-butylaMino)-2-hydroxypropoxy)phenyl)-3-cyclohexylu;1-(4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea;1-(2-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea
CBNumber: CB51073789
Molecular Formula: C20H33N3O3
Formula Weight: 363.49
MOL File: 57460-41-0.mol

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Talinolol Property

Melting point:: 160-162°C
Boiling point:: 520.0±50.0 °C(Predicted)
Density: 1.11±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 13.82±0.20(Predicted)
color: White to Pale Pink
InChI: InChI=1S/C20H33N3O3/c1-20(2,3)21-13-17(24)14-26-18-11-9-16(10-12-18)23-19(25)22-15-7-5-4-6-8-15/h9-12,15,17,21,24H,4-8,13-14H2,1-3H3,(H2,22,23,25)
InChIKey: MXFWWQICDIZSOA-UHFFFAOYSA-N
SMILES: N(C1CCCCC1)C(NC1=CC=C(OCC(O)CNC(C)(C)C)C=C1)=O

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Safety

HazardClass: IRRITANT
Toxicity: LD50 in rats, mice (mg/kg): 1180, 593 orally; 54.3, 74.7 i.p.; 29.7, 25.0 i.v. (Femmer)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3412
Product name: Talinolol
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $56.81
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3412
Product name: Talinolol
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $268
Updated: 2025/07/31

Cayman Chemical

Product number: 16116
Product name: (±)-Talinolol
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16116
Product name: (±)-Talinolol
Purity: ≥95%
Packaging: 5mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 16116
Product name: (±)-Talinolol
Purity: ≥95%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

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Talinolol Chemical Properties,Usage,Production

Description

(±)-Talinolol is a β₁-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity. By blocking β₁-adrenergic receptors, talinolol delays the conduction of stimuli in the AV node, reduces the sino-atrial conduction time, and impedes the sinus node automaticity. Because its metabolism in human liver microsomes is well understood, (±)-talinolol is useful for examining the activity of the drug-transporting MDR1 gene product P-glycoprotein.

Chemical Properties

Off-White to Pale Pink Solid

Uses

Selective β1-adrenergic blocker structurally related to Practolol. Antihypertensive; antiarrhythmic.

Definition

ChEBI: Talinolol is a member of ureas.

in vivo

Talinolol (20 mg/kg; i.p.) plasma and liver AUC_{0-5 h are increased by Zosuquidar administration^[2].

Bioavailability of Talinolol can be enhanced by coadministration with grapefruit juice (GFJ) in rats^[3].}

IC 50

Beta-1 adrenergic receptor

References

[1] abmann i. the actions of talinolol, a β1-selective beta blocker, in cardiac arrhythmia and acute myocardial infarction[j]. current medical research and opinion, 2008, 13(6): 325-342.
[2] trausch b, oertel r, richter k, et al. disposition and bioavailability of the β1‐adrenoceptor antagonist talinolol in man[j]. biopharmaceutics & drug disposition, 1995, 16(5): 403-414.

Talinolol Preparation Products And Raw materials

Raw materials

Preparation Products

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Talinolol Suppliers

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57460-41-0, TalinololRelated Search:

1-(3-(3-Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol

1-(4-(Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol

1-(4-Cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane

Cordanum

Racemic talinolol

rac-Talinolol

1-(4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea

1-(4-(3-(tert-butylaMino)-2-hydroxypropoxy)phenyl)-3-cyclohexylu

( -)-1-(4-(3-(tert-Butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylharnstoff

(+-)-1-(p-(3-(tert-Butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea

1-(2-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea

Talinolol,Beta Receptor,Adrenergic Receptor,antihypertensive,inhibit,Cordanum,Inhibitor,P-glycoprotein,cardioprotective,P-gp

Talinolol, 10 mM in DMSO

57460-41-0

C20H33N3O3

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Aromatics

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