ChemicalBook > CAS DataBase List > Talinolol

Talinolol

Product Name
Talinolol
CAS No.
57460-41-0
Chemical Name
Talinolol
Synonyms
Cordanum;rac-Talinolol ;Racemic talinolol;1-(4-(Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol;1-(4-Cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane;1-(3-(3-Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol;1-(4-(3-(tert-butylaMino)-2-hydroxypropoxy)phenyl)-3-cyclohexylu;1-(4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea;1-(2-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea;(+-)-1-(p-(3-(tert-Butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea
CBNumber
CB51073789
Molecular Formula
C20H33N3O3
Formula Weight
363.49
MOL File
57460-41-0.mol
More
Less

Talinolol Property

Melting point:
160-162°C
Boiling point:
520.0±50.0 °C(Predicted)
Density 
1.11±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
13.82±0.20(Predicted)
color 
White to Pale Pink
More
Less

Safety

HazardClass 
IRRITANT
Toxicity
LD50 in rats, mice (mg/kg): 1180, 593 orally; 54.3, 74.7 i.p.; 29.7, 25.0 i.v. (Femmer)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3412
Product name
Talinolol
Purity
≥95% (HPLC)
Packaging
5MG
Price
$64.8
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3412
Product name
Talinolol
Purity
≥95% (HPLC)
Packaging
25MG
Price
$261
Updated
2024/03/01
Cayman Chemical
Product number
16116
Product name
(±)-Talinolol
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
16116
Product name
(±)-Talinolol
Purity
≥95%
Packaging
5mg
Price
$183
Updated
2024/03/01
Cayman Chemical
Product number
16116
Product name
(±)-Talinolol
Purity
≥95%
Packaging
10mg
Price
$341
Updated
2024/03/01
More
Less

Talinolol Chemical Properties,Usage,Production

Description

(±)-Talinolol is a β1-selective adrenoceptor antagonist well known for its cardioprotective and antihypertensive activity. By blocking β1-adrenergic receptors, talinolol delays the conduction of stimuli in the AV node, reduces the sino-atrial conduction time, and impedes the sinus node automaticity. Because its metabolism in human liver microsomes is well understood, (±)-talinolol is useful for examining the activity of the drug-transporting MDR1 gene product P-glycoprotein.

Chemical Properties

Off-White to Pale Pink Solid

Uses

Selective β1-adrenergic blocker structurally related to Practolol. Antihypertensive; antiarrhythmic.

Definition

ChEBI: Talinolol is a member of ureas.

References

[1] abmann i. the actions of talinolol, a β1-selective beta blocker, in cardiac arrhythmia and acute myocardial infarction[j]. current medical research and opinion, 2008, 13(6): 325-342.
[2] trausch b, oertel r, richter k, et al. disposition and bioavailability of the β1‐adrenoceptor antagonist talinolol in man[j]. biopharmaceutics & drug disposition, 1995, 16(5): 403-414.

Talinolol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Talinolol Suppliers

Canada 1 China 24 Germany 1 India 1 United Kingdom 1 United States 9 Global 37
Tianjin Zhongtian Xinchuang Technology Co., Ltd.
Tel
13312191509
Email
1932163312@qq.com
Country
China
ProdList
293
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5047
Advantage
50
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-81024372 15029046529
Fax
029-88380327
Email
1027@dideu.com
Country
China
ProdList
10009
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44458
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Jiangsu Boquan Biotechnology Co., Ltd.
Tel
15252131412; 15252131412
Email
5954981@qq.com
Country
China
ProdList
2965
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29976
Advantage
58
Nanjing Tengyi Biotechnology Co., Ltd
Tel
025-58851786 17714337195
Email
sales@tybiochem.com
Country
China
ProdList
6829
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
Advantage
58
Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
ProdList
73043
Advantage
58
Shandong benrite new chemical materials co.,ltd
Tel
0533-2866658 15615638350
Email
sales@benritechem.com
Country
China
ProdList
3430
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
--
Fax
--
Email
sales@sunwaypharm.com
Country
China
ProdList
6536
Advantage
58
Shanghai Yubo Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
344843571@qq.com
Country
CHINA
ProdList
6318
Advantage
58
Shanghai yiji industries Co., Ltd.
Tel
--
Fax
--
Email
yiji01@foxmail.com
Country
China
ProdList
6289
Advantage
50
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6906
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

57460-41-0, TalinololRelated Search:


  • 1-(3-(3-Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol
  • 1-(4-(Cyclohexylureido)phenoxy)-3-(tert-butylamino)-2-propanol
  • 1-(4-Cyclohexylureidophenoxy)-2-hydroxy-3-tert-butylaminopropane
  • Cordanum
  • Racemic talinolol
  • rac-Talinolol
  • 1-(4-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea
  • 1-(4-(3-(tert-butylaMino)-2-hydroxypropoxy)phenyl)-3-cyclohexylu
  • ( -)-1-(4-(3-(tert-Butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylharnstoff
  • (+-)-1-(p-(3-(tert-Butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea
  • 1-(2-(3-(tert-butylamino)-2-hydroxypropoxy)phenyl)-3-cyclohexylurea
  • Talinolol,Beta Receptor,Adrenergic Receptor,antihypertensive,inhibit,Cordanum,Inhibitor,P-glycoprotein,cardioprotective,P-gp
  • 57460-41-0
  • C20H33N3O3
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals