celgosivir

Product Name: celgosivir
CAS No.: 121104-96-9
Chemical Name: celgosivir
Synonyms: BuCast;MX3253;MBI 3253;MDL 28574;celgosivir;Celgosivir (free base);6-O-butyl castanospermine;6-Butyryl castanospermine;Castanospermine 6-butyrate;MDL28574;MDL-28574;MDL 28574
CBNumber: CB51074377
Molecular Formula: C12H21NO5
Formula Weight: 259.3
MOL File: 121104-96-9.mol

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celgosivir Property

Melting point:: 114-115 °C
Boiling point:: 422.9±45.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), DMSO (Slightly)
form: Solid
pka: 13.14±0.70(Predicted)
color: White to Pale Beige
Water Solubility: H2O: 2mg/mL, clear
Stability:: Hygroscopic
InChI: 1S/C12H21NO5/c1-2-3-9(15)18-8-6-13-5-4-7(14)10(13)12(17)11(8)16/h7-8,10-12,14,16-17H,2-6H2,1H3/t7-,8-,10+,11+,12+/m0/s1
InChIKey: HTJGLYIJVSDQAE-VWNXEWBOSA-N
SMILES: O[C@@H]1[C@@H](OC(CCC)=O)CN2[C@@]([C@@H](O)CC2)([H])[C@H]1O

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C256505
Product name: Celgosivir
Packaging: 25mg
Price: $430
Updated: 2021/12/16

TRC

Product number: C256505
Product name: Celgosivir
Packaging: 100mg
Price: $1280
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009217
Product name: CELGOSIVIR
Purity: 95.00%
Packaging: 100MG
Price: $3675
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009217
Product name: CELGOSIVIR
Purity: 95.00%
Packaging: 250MG
Price: $7297.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC45099
Product name: Celgosivir
Packaging: 1mg
Price: $100
Updated: 2021/12/16

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celgosivir Chemical Properties,Usage,Production

Uses

Antiviral; inhibitor ( α-glucosidase).

Uses

Celgosivir is an α-glucosidase I inhibitor.

Biological Activity

Celgosivir is a prodrug of natural bicyclic iminosugar castanospermine th at exhibits antiviral activity in vivo including HCV and dengue. Celgosivir is an inhibitor of α-glucosidases, which inhibits glycoprotein processing in cell culture. Apparently inhibition of α-glucosidases within infected cell prevents secretion of virus.

in vivo

Celgosivir fully protects AG129 mice from lethal infection with a mouse adapted dengue virus at a dose of 50 mg/kg twice daily (BID) for 5 days and is effective even after 48 h delayed treatment. The protection by celgosivir is dose- and schedule-dependent and that a twice-a-day regimen of 50, 25 or 10 mg/kg is more protective than a single daily dose of 100 mg/kg. Pharmacokinetics studies of celgosivir in mice shows that it rapidly metabolizes to castanospermine^[4]. During primary infection with a mouse-adapted DENV strain S221, mice shows increased viremia on day 3, yet 80% survived day 10 with virus completely cleared by day 8^[3].

IC 50

HIV-1

celgosivir Preparation Products And Raw materials

Raw materials

Preparation Products

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celgosivir Suppliers

China 37 Germany 1 India 1 United Kingdom 1 United States 12 Global 52

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 17714375163
Email: yftan@aikonchem.com
Country: China
ProdList: 16676
Advantage: 50

SPIRO PHARMA

Tel
Fax: -
Email: eric_feng1954@126.com
Country: China
ProdList: 9248
Advantage: 55

Shanghai ChengShao Biological Technology Co., Ltd.

Tel: 021-61847300 13341622919
Fax: 021-61847300
Email: shcss01@163.com
Country: China
ProdList: 4808
Advantage: 58

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

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View Lastest Price from celgosivir manufacturers

Career Henan Chemical Co

Product: celgosivir 121104-96-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200g
Release date: 2020-02-01

121104-96-9, celgosivirRelated Search:

CASTANOSPERMINE

celgosivir

MDL 28574

(1S)-1,2,3,5,6,7,8,8aα-Octahydro-6α-butyryloxyindolizine-1β,7β,8α-triol

6-Butyryl castanospermine

Castanospermine 6-butyrate

BuCast

MDL28574;MDL-28574;MDL 28574

MBI 3253

MX3253

Butanoic acid, (1S,6S,7S,8R,8aR)-octahydro-1,7,8-trihydroxy-6-indolizinyl ester

6-O-butyl castanospermine

Celgosivir (free base)

121104-96-9