Tafenoquine
- Product Name
- Tafenoquine
- CAS No.
- 106635-80-7
- Chemical Name
- Tafenoquine
- Synonyms
- Krintafe;Tafenoquine;SB252263-AAB;SB 252263-AAB;TafenoIquine.;tafenoquine,Etaquine,WR 238605,SB-252263;WR-238605, WR 238605, WR238605, SB-252263-AAB;WR 238605; WR238605; WR-238605; SB-252263; SB 252263; SB252263;4-[5-[3-(Trifluoromethyl)phenoxy]-2,6-dimethoxy-4-methyl-8-quinolinylamino]-1-pentanamine;N4-{2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl}-1,4-pentanediamine
- CBNumber
- CB51075086
- Molecular Formula
- C24H28F3N3O3
- Formula Weight
- 463.49
- MOL File
- 106635-80-7.mol
Tafenoquine Property
- Melting point:
- 60 - 63°C
- Boiling point:
- 565.6±50.0 °C(Predicted)
- Density
- 1.237±0.06 g/cm3(Predicted)
- storage temp.
- 4°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 10.36±0.10(Predicted)
- form
- Solid
- color
- Dark Orange to Very Dark Orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T004765
- Product name
- Tafenoquine
- Packaging
- 25mg
- Price
- $530
- Updated
- 2021/12/16
- Product number
- T004765
- Product name
- Tafenoquine
- Packaging
- 50mg
- Price
- $1010
- Updated
- 2021/12/16
- Product number
- API0015866
- Product name
- N-(5-AMINOPENTAN-2-YL)-2,6-DIMETHOXY-4-METHYL-5-[3-(TRIFLUOROMETHYL)PHENOXY]QUINOLIN-8-AMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.34
- Updated
- 2021/12/16
- Product number
- CSN20176
- Product name
- Tafenoquine
- Packaging
- 25mg
- Price
- $606
- Updated
- 2021/12/16
- Product number
- CSN20176
- Product name
- Tafenoquine
- Packaging
- 1mg
- Price
- $132
- Updated
- 2021/12/16
Tafenoquine Chemical Properties,Usage,Production
Uses
Tafenoquine is a pharmaceutical developed for the treatment of Plasmodium vivax malaria. Tafenoquine is also being explored for pharmaceutical use for inhibition of Toxoplasma gondii growth.
Definition
ChEBI: N(4)-{2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl}pentane-1,4-diamine is an aminoquinoline that is 8-aminoquinoline which is substituted by methoxy groups at positions 2 and 6, a methyl group at position 4, and a m-(trifluoromethyl)phenoxy group at position 5, and in which the amino substituent at position 8 is itself substituted by a 5-aminopentan-2-yl group. It is a member of (trifluoromethyl)benzenes, an aminoquinoline, an aromatic ether, a primary amino compound and a secondary amino compound.
Pharmaceutical Applications
Etaquine. A synthetic 8-aminoquinoline, formulated as the
succinate for oral administration. Tafenoquine is an effective
schizonticide against P. falciparum and P. vivax. It is also
active against the pre-erythrocytic stages of these species and
the hypnozoites of P. vivax. A dosage of 100 mg base corresponds
to 125 mg salt. Oral absorption is slow with a maximum
plasma concentration reached after 12 h. The half-life is
2 weeks, significantly longer than that of primaquine. It is not
eliminated via the kidneys. Toxicity and side effects are similar
to those of primaquine. Development of methemoglobinemia
is common. Patients with G6PD deficiency may develop
severe hemolysis.
It is in clinical development for the treatment and prophylaxis
of P. vivax malaria and for the treatment of P. falciparum
infection.
Tafenoquine Preparation Products And Raw materials
Raw materials
Preparation Products
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