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4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI)

Product Name
4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI)
CAS No.
3709-98-6
Chemical Name
4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI)
Synonyms
2-ethylpyriMidine-4,6-diol;2-Ethyl-4,6-pyrimidinediol;2-ethyl-6-hydroxy-3H-pyrimidin-4-one;2-ethyl-4-hydroxy-1H-pyrimidin-6-one;2-Ethyl-6-hydroxy-4(3H)-pyrimidinone;2-ethyl-6-hydroxypyrimidin-4(1H)-one;4(1H)-PyriMidinone, 2-ethyl-6-hydroxy-;4(3H)-Pyrimidinone, 2-ethyl-6-hydroxy-;4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI);4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI) ISO 9001：2015 REACH
CBNumber
CB51081612
Molecular Formula
C6H8N2O2
Formula Weight
140.14
MOL File
3709-98-6.mol
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4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI) Property

Melting point:
>280℃
Density 
1.35
storage temp. 
Inert atmosphere,Room Temperature
pka
6.46±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific
Product number
Z4666
Product name
2-Ethyl-4,6-dihydroxypyrimidine
Packaging
250mg
Price
$97
Updated
2021/12/16
Apolloscientific
Product number
OR927450
Product name
2-Ethyl-4,6-dihydroxypyrimidine
Purity
95%
Packaging
250mg
Price
$170
Updated
2021/12/16
Matrix Scientific
Product number
064495
Product name
2-Ethyl-6-hydroxypyrimidin-4(3H)-one
Packaging
500mg
Price
$289
Updated
2021/12/16
AK Scientific
Product number
Z4666
Product name
2-Ethyl-4,6-dihydroxypyrimidine
Packaging
5g
Price
$331
Updated
2021/12/16
Apolloscientific
Product number
OR927450
Product name
2-Ethyl-4,6-dihydroxypyrimidine
Purity
95%
Packaging
1g
Price
$335
Updated
2021/12/16
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4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI) Chemical Properties,Usage,Production

Uses

2-Ethyl-6-hydroxy-4(3H)-pyrimidinone is used in the synthesis of Phosphodiesterase 10 (PDE10) inhibitors.

Synthesis

3599-89-1

105-53-3

3709-98-6

The general procedure for synthesizing 2-ethyl-4,6-dihydroxypyrimidine from propionamidine hydrochloride and diethyl malonate was as follows: referring to the method for the preparation of 2-ethylpyrimidine-4,6-diol in Example 29, to a solution of methanol (20 mL) of the compound obtained by reference to Example 28 (11 g, 99 mmol) a methanol solution of sodium methanolate 28% (57 g, 296 mmol) was added , and stirred for 10 minutes at room temperature. Subsequently, diethyl malonate (15 mL, 99 mmol) was slowly added dropwise and the reaction continued to be stirred at room temperature for 16 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue was dissolved in water and acidified with concentrated hydrochloric acid. The precipitated solid was collected by filtration, washed sequentially with water and ether, and dried to give white crystals of 2-ethyl-4,6-dihydroxypyrimidine (9.3 g, 67% yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 1.16 (3H, t, J=7.6 Hz), 2.36-2.60 (2H, m), 5.03 (1H, s), 11.62 (2H, br s).

References

[1] Patent: EP2471793, 2012, A1. Location in patent: Page/Page column 48
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 4777 - 4791
[3] Patent: WO2017/12576, 2017, A1. Location in patent: Page/Page column 77

4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI) Suppliers

China 40 Europe 1 India 1 Ukraine 1 United Kingdom 1 United States 10 Global 54
Wuhan Chemwish Technology Co., Ltd
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86-027-67849912
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sales@chemwish.com
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China
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Heterochem
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+86057186818502 13588463833
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SynAsst Chemical.
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Amadis Chemical Company Limited
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Aikon International Limited
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025-58859352 19370895928
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Shanghai Jizhi Biochemical Technology Co. Ltd.
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View Lastest Price from 4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI) manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
2-Ethyl-6-hydroxy-4(3H)-pyrimidinone 3709-98-6
Price
US $2.20-8.80/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-06-24
Dideu Industries Group Limited
Product
4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI) 3709-98-6
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-10
Career Henan Chemical Co
Product
4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI) 3709-98-6
Price
US $2.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
ask
Release date
2019-12-24

3709-98-6, 4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI)Related Search:

ETRIMFOS 2-TERT-BUTYL-4,6-DIHYDROXYPYRIMIDINE 6-CHLORO-N-[4-[A-(4,6-DIMETHOXYPYRIMIDIN-2-YL)BENZYLTHIO]PHENYL]PYRIDINE-3-CARBOXAMIDE 2,6-DIFLUORO-N-[2-[A-(4,6-DIMETHOXYPYRIMIDIN-2-YL)BENZYLTHIO]ETHYL]BENZAMIDE 2-[A-(4,6-DIMETHOXYPYRIMIDIN-2-YL)BENZYLTHIO]ETHYLAMINE N-[4-[A-(4,6-DIMETHOXYPYRIMIDIN-2-YL)BENZYLTHIO]PHENYL]THIOPHENE-2-CARBOXAMIDE N-[2-[A-(4,6-DIMETHOXYPYRIMIDIN-2-YL)BENZYLTHIO]ETHYL]-2,6-DIMETHOXYBENZAMIDE 2-(DIPHENYLMETHYL)-4,6-DIMETHOXYPYRIMIDINE 6-CHLORO-N-[2-[A-(4,6-DIMETHOXYPYRIMIDIN-2-YL)BENZYLTHIO]ETHYL]PYRIDINE-3-CARBOXAMIDE N-[4-[A-(4,6-DIMETHOXYPYRIMIDIN-2-YL)BENZYLTHIO]PHENYL]-2,6-DIMETHOXYBENZAMIDE N-[2-[A-(4,6-DIMETHOXYPYRIMIDIN-2-YL)BENZYLTHIO]ETHYL]-4-PHENYLBENZAMIDE 4-[A-(4,6-DIMETHOXYPYRIMIDIN-2-YL)BENZYLTHIO]BENZAMINE 2,6-DIFLUORO-N-[4-[A-(4,6-DIMETHOXYPYRIMIDIN-2-YL)BENZYLTHIO]PHENYL]BENZAMIDE N-[2-[A-(4,6-DIMETHOXYPYRIMIDIN-2-YL)BENZYLTHIO]ETHYL]FURAN-2-CARBOXAMIDE 2-[2-[A-(4,6-DIMETHOXYPYRIMIDIN-2-YL)BENZYLTHIO]ETHYLAMINOCARBONYL]CYCLOHEXANECARBOXYLIC ACID METHYL ESTER 2-tert-butyl-5-methyl-4,6-pyrimidinediol 2-(4-METHOXYBENZYL)-4,6-PYRIMIDINEDIOL N-[4-[A-(4,6-DIMETHOXYPYRIMIDIN-2-YL)BENZYLTHIO]PHENYL]-3-(TRIFLUOROMETHYL)BENZAMIDE

  • 2-Ethyl-4,6-pyrimidinediol
  • 2-Ethyl-6-hydroxy-4(3H)-pyrimidinone
  • 4(1H)-PyriMidinone, 2-ethyl-6-hydroxy-
  • 2-ethyl-6-hydroxypyrimidin-4(1H)-one
  • 2-ethylpyriMidine-4,6-diol
  • 2-ethyl-6-hydroxy-3H-pyrimidin-4-one
  • 4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI)
  • 4(3H)-Pyrimidinone, 2-ethyl-6-hydroxy-
  • 4(1H)-Pyrimidinone, 2-ethyl-6-hydroxy- (9CI) ISO 9001：2015 REACH
  • 2-ethyl-4-hydroxy-1H-pyrimidin-6-one
  • 3709-98-6
  • PYRIMIDINE