4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI)
- Product Name
- 4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI)
- CAS No.
- 1194-74-7
- Chemical Name
- 4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI)
- Synonyms
- 2,5-diMethylpyriMidine-4,6-diol;dimethyl-4,6-dihydroxy-pyrimidine;2,5-dimethyl-4,6-dihydroxy-pyrimidine;-Pyrimidinone,6-hydroxy-2,5-dimethyl-;4, 6-Dihydroxy-2,5-Dimethyl Pyrimidine;6-Hydroxy-2,5-dimethyl-4(3H)-pyrimidinone;6-Hydroxy-2,5-Dimethyl-4(1H)-Pyrimidinone;4-hydroxy-2,5-dimethyl-1H-pyrimidin-6-one;6-hydroxy-2,5-dimethylpyrimidin-4(3H)-one;4(3H)-PyriMidinone, 6-hydroxy-2,5-diMethyl-
- CBNumber
- CB51081692
- Molecular Formula
- C6H8N2O2
- Formula Weight
- 140.14
- MOL File
- 1194-74-7.mol
4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI) Property
- Melting point:
- >360 °C
- Density
- 1.36±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 6.93±0.10(Predicted)
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D477925
- Product name
- 2,5-Dimethylpyrimidine-4,6-diol
- Packaging
- 25g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- CHM0294903
- Product name
- 2,5-DIMETHYL-4,6-DIHYDROXYPYRIMIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.83
- Updated
- 2021/12/16
- Product number
- 152997
- Product name
- 2,5-Dimethylpyrimidine-4,6-diol
- Purity
- 95%
- Packaging
- 5g
- Price
- $396
- Updated
- 2021/12/16
- Product number
- 152997
- Product name
- 2,5-Dimethylpyrimidine-4,6-diol
- Purity
- 95%
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- OR918718
- Product name
- 2,5-Dimethyl-4,6-dihydroxypyrimidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI) Chemical Properties,Usage,Production
Uses
2,5-Dimethylpyrimidine-4,6-diol is a chemical reagent used in the synthesis of pharmaceutically active dimethylpyrimidines.
Synthesis
609-08-5
1194-74-7
The general procedure for the synthesis of 6-hydroxy-2,5-dimethyl-4(1H)-pyrimidinone from diethyl methylmalonate is as follows: Example 4.1 Synthesis of 2,5-dimethyl-4,6-dihydroxypyrimidine To a single neck flask 40 mL of methanol was added and cooled to 0°C with an ice bath under nitrogen atmosphere. To the reaction mixture was added 9.72 g of sodium methanol (i.e., a solution with a concentration of 3 mol/L), followed by the slow addition of 5 g (53 mmol) of acetamidine hydrochloride at 0 °C. The reaction mixture was stirred at room temperature for about 20 minutes, then 8.3 mL of diethyl methylmalonate was added dropwise. Stirring was continued for 3 hours. After completion of the reaction, the methanol was concentrated under reduced pressure (2 kPa). The crude product was dissolved in a minimal amount of water, cooled to 0 °C, and then acidified with pure acetic acid to pH 4-5. The white precipitate formed was collected by filtration and washed sequentially with water, ether, and pentane. Finally, the white product was dried over P2O5 under reduced pressure (0.2 kPa) to give 3.3 g (49% yield) of the target product. TLC analysis: Rf = 0.2 (silica gel, eluent: dichloromethane-methanol-water-acetic acid, 85:15:2:2). 1H-NMR (DMSO-d6): δ 1.68 (s, 3H, OH-CH2C-CH3); 2.18 (s, 3H, N-C-CH3).
References
[1] Patent: US2006/52398, 2006, A1. Location in patent: Page/Page column 74-75
4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
View Lastest Price from 4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI) manufacturers
- Product
- 4(1H)-Pyrimidinone, 6-hydroxy-2,5-dimethyl- (9CI) 1194-74-7
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2020-02-20