4-methyl-2-chloro-pyrimidine-5-carboxylic acid
- Product Name
- 4-methyl-2-chloro-pyrimidine-5-carboxylic acid
- CAS No.
- 188781-10-4
- Chemical Name
- 4-methyl-2-chloro-pyrimidine-5-carboxylic acid
- Synonyms
- 5-Carboxy-2-chloro-4-methylpyrimidine;4-methyl-2-chloro-pyrimidine-5-carboxylic acid;2-chloro-4-methyl-5-Pyrimidine carboxylic acid;4-ethyl-2-hydroxy-pyrimidine-5-carboxylic acid;5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl-;5-Pyrimidinecarboxylic acid, 2-chloro-4-methyl- (9CI);5-Carboxy-2-chloro-4-methylpyrimidine, 2-Chloro-4-methyl-1,3-diazine-5-carboxylic acid
- CBNumber
- CB51082235
- Molecular Formula
- C6H5ClN2O2
- Formula Weight
- 172.57
- MOL File
- 188781-10-4.mol
4-methyl-2-chloro-pyrimidine-5-carboxylic acid Property
- Boiling point:
- 375.3±22.0 °C(Predicted)
- Density
- 1.479±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.06±0.25(Predicted)
- form
- powder
- color
- Faint yellow
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C384750
- Product name
- 2-Chloro-4-methylpyrimidine-5-carboxylicAcid
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 4H21-5-Y7
- Product name
- 2-Chloro-4-methylpyrimidine-5-carboxylic acid
- Packaging
- 250mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- 101837
- Product name
- 2-Chloro-4-methylpyrimidine-5-carboxylic acid
- Purity
- 95%
- Packaging
- 250mg
- Price
- $212
- Updated
- 2021/12/16
- Product number
- 101837
- Product name
- 2-Chloro-4-methylpyrimidine-5-carboxylic acid
- Purity
- 95%
- Packaging
- 500mg
- Price
- $341
- Updated
- 2021/12/16
- Product number
- 4H21-5-Y7
- Product name
- 2-Chloro-4-methylpyrimidine-5-carboxylic acid
- Packaging
- 1g
- Price
- $490
- Updated
- 2021/12/16
4-methyl-2-chloro-pyrimidine-5-carboxylic acid Chemical Properties,Usage,Production
Synthesis
188781-08-0
188781-10-4
The general procedure for the synthesis of 2-chloro-4-methylpyrimidine-5-carboxylic acid from ethyl 4-methyl-2-chloropyrimidine-5-carboxylate is as follows: Example 9: Ethyl 2-chloro-4-methylpyrimidine-5-carboxylate (1.0 g, 5 mmol) was reacted with an aqueous solution (30 mL) of NaOH (0.24 g, 6 mmol) with stirring at room temperature for 3 hours. After completion of the reaction, the reaction solution was acidified with 6N HCl and the precipitated solid was filtered and dried to afford 2-chloro-4-methylpyrimidine-5-carboxylic acid (0.67 g, 78% yield). The product was characterized by 1H NMR (DMSO-d6): δ 9.01 (s, 1H), 2.75 (s, 3H).
References
[1] Journal of medicinal chemistry, 2000, vol. 43, # 21, p. 3995 - 4004
[2] Patent: US5935966, 1999, A
[3] Patent: US5811428, 1998, A
4-methyl-2-chloro-pyrimidine-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-methyl-2-chloro-pyrimidine-5-carboxylic acid Suppliers
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- info@chemstep.com
- Country
- Europe
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View Lastest Price from 4-methyl-2-chloro-pyrimidine-5-carboxylic acid manufacturers
- Product
- 2-Chloro-4-methylpyrimidine-5-carboxylic acid 188781-10-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2025-09-24
- Product
- 4-methyl-2-chloro-pyrimidine-5-carboxylic acid 188781-10-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 97.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-19