1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI)
- Product Name
- 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI)
- CAS No.
- 171919-36-1
- Chemical Name
- 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI)
- Synonyms
- 1-methylpyrrolo[2,3-b]pyridine-3-carbaldehyde;1-Methy-1H-Pyrrolo[2,3-b]pyridine-3-carbaldehyde;1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde;1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl-;1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 97%;1-Methyl-1H-Pyrrolo[2,3-B]Pyridine-3-Carbaldehyde(WX624086);1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI)
- CBNumber
- CB51089885
- Molecular Formula
- C9H8N2O
- Formula Weight
- 160.17
- MOL File
- 171919-36-1.mol
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI) Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M331563
- Product name
- 1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR301278
- Product name
- 1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 038942
- Product name
- 1-Methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
- Purity
- 95%
- Packaging
- 500mg
- Price
- $189
- Updated
- 2021/12/16
- Product number
- CHM0083716
- Product name
- 1-METHYL-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $785.4
- Updated
- 2021/12/16
- Product number
- 171919361
- Product name
- 1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde
- Packaging
- 10g
- Price
- $202.3
- Updated
- 2021/12/16
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI) Chemical Properties,Usage,Production
Synthesis
27257-15-4
68-12-2
171919-36-1
b) Synthesis of 1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde: Phosphorus trichloride (1.2 g, 7.9 mmol) was slowly added dropwise to 10 mL of N,N-dimethylformamide at 0 °C with stirring. After the dropwise addition, stirring was continued for 10 minutes. Subsequently, a solution of 1-methyl-7-azaindole (0.95 g, 7.2 mmol) dissolved in 5 mL of N,N-dimethylformamide was added over 1 min. The reaction mixture was stirred at 0°C for 1 hour, followed by warming to 60°C and continued stirring for 30 minutes. Upon completion of the reaction, the mixture was poured into water, adjusted to alkaline with aqueous sodium bicarbonate and extracted three times with ethyl acetate. The organic layers were combined, washed with water, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was obtained as 0.85 g in 74% yield, and the purity met the requirements of the subsequent reaction.1H NMR (300MHz, CDCl3) δ: 9.99 (s, 1H), 8.55 (m, 1H), 8.44 (m, 1H), 7.84 (s, 1H), 7.27 (m, 1H), 3.97 (s, 3H).
References
[1] Chemical and pharmaceutical bulletin, 1995, vol. 43, # 8, p. 1351 - 1357
[2] Patent: WO2005/66132, 2005, A1. Location in patent: Page/Page column 66
[3] Heteroatom Chemistry, 2011, vol. 22, # 2, p. 148 - 157
[4] Patent: WO2009/3003, 2008, A2. Location in patent: Page/Page column 61-62
[5] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 3, p. 1201 - 1212
1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI) Preparation Products And Raw materials
Raw materials
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View Lastest Price from 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI) manufacturers
- Product
- 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 1-methyl- (9CI) 171919-36-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-20