3-BROMO-5-(TRIFLUOROMETHYL)BENZYL ALCOHOL
- Product Name
- 3-BROMO-5-(TRIFLUOROMETHYL)BENZYL ALCOHOL
- CAS No.
- 172023-97-1
- Chemical Name
- 3-BROMO-5-(TRIFLUOROMETHYL)BENZYL ALCOHOL
- Synonyms
- 3-BroMo-5-(trifluoroMethyl)benzyl acohol;3-BROMO-5-(TRIFLUOROMETHYL)BENZYL ALCOHOL;3-Bromo-5-(trifluoromethyl)benzenemethanol;[3-BROMO-5-(TRIFLUOROMETHYL)PHENYL]METHANOL;Benzenemethanol, 3-bromo-5-(trifluoromethyl)-;3-Bromo-5-(trifluoromethyl)benzyl alcohol 98%;(3-Bromo-5-(trifluoromethyl)phenyl)methanol M61623
- CBNumber
- CB51091534
- Molecular Formula
- C8H6BrF3O
- Formula Weight
- 255.03
- MOL File
- 172023-97-1.mol
3-BROMO-5-(TRIFLUOROMETHYL)BENZYL ALCOHOL Property
- Boiling point:
- 243.0±35.0 °C(Predicted)
- Density
- 1.667±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 13.87±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2908190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B700323
- Product name
- (3-Bromo-5-(trifluoromethyl)phenyl)methanol
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- W3746
- Product name
- (3-Bromo-5-(trifluoromethyl)phenyl)methanol
- Packaging
- 1g
- Price
- $82
- Updated
- 2021/12/16
- Product number
- 2801-B-08
- Product name
- 3-Bromo-5-(trifluoromethyl)benzenemethanol
- Purity
- 98%
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- 087183
- Product name
- 3-Bromo-5-(trifluoromethyl)benzyl alcohol
- Purity
- 98%
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
- Product number
- W3746
- Product name
- (3-Bromo-5-(trifluoromethyl)phenyl)methanol
- Packaging
- 5g
- Price
- $143
- Updated
- 2021/12/16
3-BROMO-5-(TRIFLUOROMETHYL)BENZYL ALCOHOL Chemical Properties,Usage,Production
Synthesis
537039-44-4
172023-97-1
General procedure for the synthesis of 3-bromo-5-(trifluoromethyl)benzyl alcohol from (3-amino-5-(trifluoromethyl)phenyl)methanol: (3-amino-5-(trifluoromethyl)phenyl)methanol (1.6 g, 8.4 mmol) was dissolved in anhydrous acetonitrile (10 mL) and was added slowly and dropwise to a solution of acetonitrile (20 mL) containing copper(II) bromide (2.24 g, 10.0 mmol) and tert-butyl nitrite (1.48 mL, 12.0 mmol) in a solution of acetonitrile (20 mL). The reaction mixture was stirred at 65 °C for 30 min, then cooled to room temperature, poured into 1N hydrochloric acid solution and extracted with ethyl acetate (2×). The organic layers were combined, washed with brine (2×), dried over anhydrous sodium sulfate and concentrated. Purification by silica gel column chromatography (20% ethyl acetate/hexane) afforded the target product 3-bromo-5-(trifluoromethyl)benzyl alcohol (1.48 g, 69% yield).1H-NMR (CDCl3, 500 MHz) δ 7.71 (s, 1H), 7.68 (s, 1H), 7.55 (s, 1H), 4.75 (s, 2H).
References
[1] Patent: US2007/249607, 2007, A1. Location in patent: Page/Page column 62
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 15, p. 3039 - 3043
[3] Patent: WO2007/88999, 2007, A1. Location in patent: Page/Page column 164-165
[4] Patent: WO2007/116922, 2007, A1. Location in patent: Page/Page column 54
[5] Patent: WO2005/100298, 2005, A1. Location in patent: Page/Page column 65
3-BROMO-5-(TRIFLUOROMETHYL)BENZYL ALCOHOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BROMO-5-(TRIFLUOROMETHYL)BENZYL ALCOHOL manufacturers
- Product
- 3-BROMO-5-(TRIFLUOROMETHYL)BENZYL ALCOHOL 172023-97-1
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12