Troparil

ChemicalBook > CAS DataBase List > Troparil

Product Name: Troparil
CAS No.: 74163-84-1
Chemical Name: Troparil
Synonyms: Β-CPT;B-CPT;Tropari;Troparil;Topalate;Troparil Β-CPT;Troparil Whatsapp;Troparil Impurity;Troparil USP/EP/BP;high purity,Troparil
CBNumber: CB51095921
Molecular Formula: C16H21NO2
Formula Weight: 259.34
MOL File: 74163-84-1.mol

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Troparil Property

Boiling point:: 350.2±42.0 °C(Predicted)
Density: 1.099±0.06 g/cm3(Predicted)
pka: 9.95±0.60(Predicted)
InChI: InChI=1/C16H21NO2/c1-17-12-8-9-14(17)15(16(18)19-2)13(10-12)11-6-4-3-5-7-11/h3-7,12-15H,8-10H2,1-2H3/t12-,13+,14+,15-/s3
InChIKey: OMBOXYLBBHNWHL-YRABYYAXNA-N
SMILES: [C@@]12([H])N(C)[C@@]([H])(CC1)C[C@H](C1=CC=CC=C1)[C@@H]2C(OC)=O |&1:0,4,9,16,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0016898
Product name: TROPARIL
Purity: 95.00%
Packaging: 5MG
Price: $504.66
Updated: 2021/12/16

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Troparil Chemical Properties,Usage,Production

Description

Troparil is a phenyltropane-based dopamine reuptake inhibitor that is derived from methylecgonidine. It is a stimulant drug used in scientific research. The most commonly used form of troparil is the tartrate salt, but the hydrochloride and naphthalenedisulfonate salts are also available, as well as the free base.

History

Troparil (another name: WIN 35,065-2) is a synthetic derivative of cocaine and was synthesized during the 1970s to separate the stimulant and depressant actions of cocaine from its toxicity and dependence liability. This compound was also used as a starting material or intermediate in synthesising several 3β-phenyltropane derivatives. With a phenyl group directly attached to the tropane ring, troparil is a 3-phenyltropane.

Uses

Troparil is used in scientific research into the dopamine reuptake transporter. 3H-radiolabelled forms of troparil have been used in humans and animals to map the distribution of dopamine transporters in the brain. It is also used for animal research into stimulant drugs as an alternative to cocaine which produces similar effects, but avoids the stringent licensing requirements for the use of cocaine itself.

Pharmacokinetics

Troparil is a few times more potent than cocaine as a dopamine reuptake inhibitor, but is less potent as a serotonin reuptake inhibitor, and has a duration spanning a few times longer, since the phenyl ring is directly connected to the tropane ring through a non-hydrolyzable carbon-carbon bond. The lack of an ester linkage removes the local anesthetic action from the drug, so troparil is a pure stimulant. This change in activity also makes troparil slightly less cardiotoxic than cocaine.

Troparil Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Troparil manufacturers

Hebei Longbang Technology Co., Ltd

Product: Troparil 74163-84-1
Price: US $6.00/kg
Min. Order: 1kg
Purity: More than 99%
Supply Ability: 2000KG/Month
Release date: 2024-06-05

HebeiShuoshengImportandExportco.,Ltd

Product: Tropari 74163-84-1
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-07

Dorne Chemical Technology co. LTD

Product: Troparil Β-CPT 74163-84-1
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

74163-84-1, TroparilRelated Search:

dichloropane 8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)-, METHYL ESTER (1R,2S,3S,5S)- (-)-2-BETA-CARBOMETHOXY-3-BETA-(4-FLUOROPHENYL)TROPANE (-)-2-BETA-CARBOMETHOXY-3-BETA-(IODOPHENYL)TROPANE (1R,2S,3S,5S)-3-(4-AMINO-PHENYL)-8-METHYL-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTER Troparil (1R,2S,3S,5S)-8-METHYL-3-(4-NITRO-PHENYL)-8-AZA-BICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID METHYL ESTER WIN 35,428, [N-METHYL-3H]- 2-FE-BETA-CIT 8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-METHYL-3-[4-(TRIMETHYL-STANNYL)PHENYL]-, METHYL ESTER, [1R-(EXO, EXO)]- (-)-2-BETA-CARBOMETHOXY-3-BETA-(PHENYL)TROPANE 8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-(2-FLUOROETHYL)-3-(4-IODOPHENYL)-, METHYL ESTER, (1R, 2S, 3S, 5S)- 8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 8-(3-FLUOROPROPYL)-3-(4-IODOPHENYL)-, METHYL ESTER (1R,2S,3S,5S)- RTI-55, [125I]- (E)-N-3-(IODOPROP-2-ENYL)2BETA-CARBOMETHOXY-3BETA-(P-TOLYL)-NORTROPAN 8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC ACID, 3-(4-CHLOROPHENYL)-8-(2-FLUOROETHYL)-, METHYL ESTER, (1R,2S,3S,5S)- technepine RTI-121, [125I]-

2β-Carbomethoxy-3β-phenyltropane

B-CPT

Troparil

(Exo,exo)-8-methyl-3-phenyl-8-azabicyclo(3.2.1)octane-2-carboxylic acid methyl ester

2-beta-Methoxycarbonyl-3-beta-phenyltropane

8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 8-methyl-3-phenyl-, methyl ester, (exo,exo)-

8-Azabicyclo[3.2.1]octane-2-carboxylicacid, 8-Methyl-3-phenyl-, Methyl ester, (1R,2S,3S,5S)-rel-

(–)-2β-Carbomethoxy-3β-phenyltropane,WIN 35,065-2, orβ-CPT)

Β-CPT

Troparil Whatsapp

methyl 8-methyl-3-phenyl-8-azabicyclo[3.2.1]octane-4-carboxylate

Troparil Β-CPT

Troparil USP/EP/BP

high purity,Troparil

2β-Carbomethoxy-3β-phenyltropane

2-beta-Methoxycarbonyl

Topalate

(–)-2β-Carbomethoxy-3β-phenyltropane

Tropari

Troparil Impurity

74163-84-1