2-Iodopyrimidine
- Product Name
- 2-Iodopyrimidine
- CAS No.
- 31462-54-1
- Chemical Name
- 2-Iodopyrimidine
- Synonyms
- 2-Iodopyrimidine;PyriMidine, 2-iodo-;2-Iodopyrimidine 95%;2-Iodopyrimidine,>97%;2-Iodopyrimidine ISO 9001：2015 REACH
- CBNumber
- CB51096140
- Molecular Formula
- C4H3IN2
- Formula Weight
- 205.98
- MOL File
- 31462-54-1.mol
2-Iodopyrimidine Property
- Melting point:
- 30-32 °C
- Boiling point:
- 277.4±23.0 °C(Predicted)
- Density
- 2.102±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder to crystal
- pka
- -1.18±0.13(Predicted)
- color
- White to Orange to Green
- InChI
- InChI=1S/C4H3IN2/c5-4-6-2-1-3-7-4/h1-3H
- InChIKey
- AXDGIPMYJALRKV-UHFFFAOYSA-N
- SMILES
- C1(I)=NC=CC=N1
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- I0988
- Product name
- 2-Iodopyrimidine
- Packaging
- 1G
- Price
- $192
- Updated
- 2025/07/31
- Product number
- I719593
- Product name
- 2-Iodopyrimidine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR54388
- Product name
- 2-Iodopyrimidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- 3H32-H-77
- Product name
- 2-Iodopyrimidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
- Product number
- 119419
- Product name
- 2-Iodopyrimidine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $188
- Updated
- 2021/12/16
2-Iodopyrimidine Chemical Properties,Usage,Production
Chemical Properties
Light yellow powder
Synthesis
1722-12-9
31462-54-1
Under nitrogen protection, 2-chloropyrimidine (200 g, 1.75 mol) was slowly added in five portions to an aqueous solution of hydriodic acid (850 ml, 57%) pre-cooled to -10 to -5 °C. The reaction temperature was maintained in the range of -10 to -5°C and the progress of the reaction was monitored by high performance liquid chromatography (HPLC). After completion of the reaction (60 to 120 min), the pH was adjusted to 7.25 ± 0.25 with 30% sodium hydroxide solution and the temperature of the reaction mixture was raised to 18-23°C. Subsequently, sodium sulfite (16 g) was added for decolorization and the pH was adjusted to 3 ± 1. Tert-butyl methyl ether (TBME, 600 ml) was added to the mixture and saturated with sodium chloride (300 g). The organic and aqueous phases were separated and the aqueous phase was extracted with tert-butyl methyl ether (4 x 400 ml). The organic layers were combined and washed sequentially with 1% aqueous sodium sulfite (50 ml) and water (100 ml). The organic layers were concentrated to dryness and co-evaporated with tert-butyl methyl ether (100 ml) at 45 to 50 °C to remove residual water. The final product 2-iodopyrimidine 330 g was obtained in 90% yield and 98% purity as determined by HPLC, which was consistent with the standard.
References
[1] Patent: US2006/58343, 2006, A1. Location in patent: Page/Page column 7
[2] Journal of Organic Chemistry, 2002, vol. 67, # 18, p. 6550 - 6552
[3] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1990, # 7, p. 1269 - 1274
[4] Patent: EP2395055, 2011, A1. Location in patent: Page/Page column 8
[5] Journal of the American Chemical Society, 2012, vol. 134, # 12, p. 5528 - 5531
2-Iodopyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Iodopyrimidine manufacturers
- Product
- 2-Iodopyrimidine 31462-54-1
- Price
- US $36.00-1.10/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-08
- Product
- 2-Iodopyrimidine 31462-54-1
- Price
- US $5.99/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2021-09-24
- Product
- 2-Iodopyrimidine 31462-54-1
- Price
- US $5.99/KG
- Min. Order
- 1KG
- Purity
- 98/%
- Supply Ability
- 10KG
- Release date
- 2021-09-24