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1-Methyl-1-nitrosourea

Product Name
1-Methyl-1-nitrosourea
CAS No.
684-93-5
Chemical Name
1-Methyl-1-nitrosourea
Synonyms
N-NITROSO-N-METHYLUREA;MNU;NMU;NMH;Nitrosomethylurea;N-METHYL-N-NITROSOUREA;N-NITROSOMETHYLUREA;sri859;SRI 859;ski24464
CBNumber
CB5109704
Molecular Formula
C2H5N3O2
Formula Weight
103.08
MOL File
684-93-5.mol
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1-Methyl-1-nitrosourea Property

Melting point:
119-124°C
Boiling point:
193.27°C (rough estimate)
Density 
1.5048 (rough estimate)
refractive index 
1.4264 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: 125 mg/mL (1212.65 mM)
form 
Solid
pka
12.36±0.50(Predicted)
color 
Off-white to light brown
Water Solubility 
14.56g/L(temperature not stated)
Stability:
Stable. Flammable. Incompatible with strong oxidizing agents, strong bases, strong acids.
CAS DataBase Reference
684-93-5(CAS DataBase Reference)
NIST Chemistry Reference
Urea, 1-methyl-1-nitroso-(684-93-5)
IARC
2A (Vol. 17, Sup 7) 1987
EPA Substance Registry System
N-Nitroso-N-methylurea (684-93-5)
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Safety

Hazard Codes 
F,T
Risk Statements 
45-46-61-11-25
Safety Statements 
53-45-24/25-22
RIDADR 
UN 1325 4.1/PG 2
WGK Germany 
-
RTECS 
YT7875000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29241990
Hazardous Substances Data
684-93-5(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 110mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

H301Toxic if swalloed

H350May cause cancer

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
M325815
Product name
N-Methyl-N-nitrosoUrea(ContainsWater)
Packaging
5g
Price
$305
Updated
2021/12/16
TRC
Product number
M325815
Product name
N-Methyl-N-nitrosoUrea(ContainsWater)
Packaging
25g
Price
$640
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0077019
Product name
N-NITROSO-N-METHYLUREA
Purity
95.00%
Packaging
2.5G
Price
$869
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0077019
Product name
N-NITROSO-N-METHYLUREA
Purity
95.00%
Packaging
25G
Price
$2333.1
Updated
2021/12/16
Oakwood
Product number
098373
Product name
N-Nitroso-N-methylurea wet with 10% acetic acid solution
Packaging
250mg
Price
$24
Updated
2021/12/16
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1-Methyl-1-nitrosourea Chemical Properties,Usage,Production

Description

Methylnitrosourea (MNU) is a methylated nitrosourea compound with alkylating,mutagenic, teratogenic, carcinogenic, and cytotoxic properties. The toxic effects of MNU are caused by the transfer of its methyl group to nucleobases in nucleic acids.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

MNU is the starting material for diazomethane generation. Diazomethane provides methyl derivatives with carboxylic acids and phenols in a very smooth and gentle reaction. Phenols are slower in their reactivity compared to carboxylic acids and should be converted at temperatures greater than 0 C. However, since MNU is unstable at temperatures greater than 20 C and is shock sensitive to a degree, other (N-methyl) nitrosamides have replaced MNU for use in diazomethane generation, and most chemical supply houses no longer carry MNU. MNU has been studied as a chemotherapeutic agent as it is an effective therapy for mice that are intraperitoneally or intracerebrally implanted with L1210 leukemia cells. MNU is currently used as a research chemical to develop animal models for human diseases.

Uses

Precursor of Diazomethane. It has a cytotoxicity effect. This product contains an undetermined amount of water

Definition

ChEBI: N-methyl-N-nitrosourea is a member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups. It has a role as a carcinogenic agent, a mutagen, a teratogenic agent and an alkylating agent.

General Description

Pale yellow crystals or light yellow moist powder.

Air & Water Reactions

Sensitive to humidity and light when pure. Insoluble in water. Slowly decomposes in water. Alkaline hydrolysis produces a highly toxic, irritating and explosive gas.

Reactivity Profile

1-Methyl-1-nitrosourea is incompatible with strong acids and bases. Also incompatible with water and nucleophilic reagents. Alkaline hydrolysis produces a highly toxic, irritating and explosive gas. Can detonate with (potassium hydroxide + methylene chloride) .

Fire Hazard

Flash point data for 1-Methyl-1-nitrosourea are not available; however, 1-Methyl-1-nitrosourea is probably combustible.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion and intravenous routes. Experimental reproductive effects. Human mutation data reported. Explodes at room temperature. Can detonate with (KOH + CHzCh). When heated to decomposition it emits toxic fumes of NOx.

Carcinogenicity

N-Nitroso-N-methylurea is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

There is no evidence that MNU has ever been produced or used commercially; therefore, no data from human case reports or epidemiological studies are available. MNU is available in small quantities for research purposes and may be released into the environment with laboratory waste. In air, MNU is expected to exist solely as a vapor with an estimated vapor pressure of 2.9×10-2 mmHg at 25℃. Vapor-phase MNU is expected to degrade in the atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of 10 days. MNU is expected to hydrolyze in moist soils; therefore, MNU adsorption and volatilization from soil are not expected to be prevalent. In water,MNUis expected to hydrolyze and has a halflife of 1.2 h at pH 7 and 20℃; therefore, volatilization, adsorption into suspended solids and sediments, biodegradation, and bioconcentration are not expected to be important processes in aquatic systems. Occupational exposure to MNU may occur through oral contact, inhalation, and/or dermal contact at workplaces where it is used as a research chemical. Potential exposure may occur during the preparation and administration ofMNUor during clean up. To avoid spills,MNU should be transported in securely sealed glass bottles or ampules, which should themselves be placed inside strong screw-cap or snap-top containers that will not open when dropped. Both bottle and the outside container should be appropriately labeled.

Toxicity evaluation

MNU is a direct-acting alkylating agent that interacts with DNA to yield a variety of reaction products. The predominant adduct (70–90%) is at the nucleophilic position 7 of guanine, yielding 7-methyldeoxyguanosine (7-medGua). While 7-medGua does not appear to be directly mutagenic, the presence of 7-medGua in susceptible tissues and cells can be used as a marker of recent exposure to methylating agents such as MNU, because it is more stable than mutagenic O6-medGua. Alterations in DNA structure that are left unrepaired may lead to an accumulation of mutations and eventually enhance cancer risk. When the DNA damage is very severe, MNU may act as a cytotoxic agent and cause cell death.

1-Methyl-1-nitrosourea Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Methyl-1-nitrosourea Suppliers

HuiFeiChem(WuXi) PharmaTech Co.,Ltd
Tel
0510-0510-83593305
Fax
0086-510-83593305
Email
sales@huifeichem.com
Country
China
ProdList
104
Advantage
62
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
ChemFuture PharmaTech (Jiangsu) Ltd
Tel
5108538618
Fax
86 510 85386988-8017
Email
suger.wang@chemfuture.com
Country
China
ProdList
832
Advantage
65
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12438
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9414
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
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View Lastest Price from 1-Methyl-1-nitrosourea manufacturers

ANHUI WITOP BIOTECH CO., LTD
Product
1-Methyl-1-nitrosourea 684-93-5
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
10 tons
Release date
2021-03-19
Career Henan Chemical Co
Product
1-Methyl-1-nitrosourea 684-93-5
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-16

684-93-5, 1-Methyl-1-nitrosoureaRelated Search:


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