1-Methyl-1-nitrosourea
- Product Name
- 1-Methyl-1-nitrosourea
- CAS No.
- 684-93-5
- Chemical Name
- 1-Methyl-1-nitrosourea
- Synonyms
- N-NITROSO-N-METHYLUREA;MNU;NMU;NMH;Nitrosomethylurea;N-METHYL-N-NITROSOUREA;N-NITROSOMETHYLUREA;sri859;SRI 859;ski24464
- CBNumber
- CB5109704
- Molecular Formula
- C2H5N3O2
- Formula Weight
- 103.08
- MOL File
- 684-93-5.mol
1-Methyl-1-nitrosourea Property
- Melting point:
- 119-124°C
- Boiling point:
- 193.27°C (rough estimate)
- Density
- 1.5048 (rough estimate)
- refractive index
- 1.4264 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO: 125 mg/mL (1212.65 mM)
- form
- Solid
- pka
- 12.36±0.50(Predicted)
- color
- Off-white to light brown
- Water Solubility
- 14.56g/L(temperature not stated)
- Stability:
- Stable. Flammable. Incompatible with strong oxidizing agents, strong bases, strong acids.
- CAS DataBase Reference
- 684-93-5(CAS DataBase Reference)
- NIST Chemistry Reference
- Urea, 1-methyl-1-nitroso-(684-93-5)
- IARC
- 2A (Vol. 17, Sup 7) 1987
- EPA Substance Registry System
- N-Nitroso-N-methylurea (684-93-5)
Safety
- Hazard Codes
- F,T
- Risk Statements
- 45-46-61-11-25
- Safety Statements
- 53-45-24/25-22
- RIDADR
- UN 1325 4.1/PG 2
- WGK Germany
- -
- RTECS
- YT7875000
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29241990
- Hazardous Substances Data
- 684-93-5(Hazardous Substances Data)
- Toxicity
- LD50 oral in rat: 110mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H228Flammable solid
H301Toxic if swalloed
H350May cause cancer
H360May damage fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- M325815
- Product name
- N-Methyl-N-nitrosoUrea(ContainsWater)
- Packaging
- 5g
- Price
- $305
- Updated
- 2021/12/16
- Product number
- M325815
- Product name
- N-Methyl-N-nitrosoUrea(ContainsWater)
- Packaging
- 25g
- Price
- $640
- Updated
- 2021/12/16
- Product number
- CHM0077019
- Product name
- N-NITROSO-N-METHYLUREA
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $869
- Updated
- 2021/12/16
- Product number
- CHM0077019
- Product name
- N-NITROSO-N-METHYLUREA
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $2333.1
- Updated
- 2021/12/16
- Product number
- 098373
- Product name
- N-Nitroso-N-methylurea wet with 10% acetic acid solution
- Packaging
- 250mg
- Price
- $24
- Updated
- 2021/12/16
1-Methyl-1-nitrosourea Chemical Properties,Usage,Production
Description
Methylnitrosourea (MNU) is a methylated nitrosourea compound with alkylating,mutagenic, teratogenic, carcinogenic, and cytotoxic properties. The toxic effects of MNU are caused by the transfer of its methyl group to nucleobases in nucleic acids.
Chemical Properties
Off-White to Pale Yellow Solid
Uses
MNU is the starting material for diazomethane generation. Diazomethane provides methyl derivatives with carboxylic acids and phenols in a very smooth and gentle reaction. Phenols are slower in their reactivity compared to carboxylic acids and should be converted at temperatures greater than 0 C. However, since MNU is unstable at temperatures greater than 20 C and is shock sensitive to a degree, other (N-methyl) nitrosamides have replaced MNU for use in diazomethane generation, and most chemical supply houses no longer carry MNU. MNU has been studied as a chemotherapeutic agent as it is an effective therapy for mice that are intraperitoneally or intracerebrally implanted with L1210 leukemia cells. MNU is currently used as a research chemical to develop animal models for human diseases.
Uses
Precursor of Diazomethane. It has a cytotoxicity effect. This product contains an undetermined amount of water
Definition
ChEBI: N-methyl-N-nitrosourea is a member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups. It has a role as a carcinogenic agent, a mutagen, a teratogenic agent and an alkylating agent.
General Description
Pale yellow crystals or light yellow moist powder.
Air & Water Reactions
Sensitive to humidity and light when pure. Insoluble in water. Slowly decomposes in water. Alkaline hydrolysis produces a highly toxic, irritating and explosive gas.
Reactivity Profile
1-Methyl-1-nitrosourea is incompatible with strong acids and bases. Also incompatible with water and nucleophilic reagents. Alkaline hydrolysis produces a highly toxic, irritating and explosive gas. Can detonate with (potassium hydroxide + methylene chloride) .
Fire Hazard
Flash point data for 1-Methyl-1-nitrosourea are not available; however, 1-Methyl-1-nitrosourea is probably combustible.
Safety Profile
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by ingestion and intravenous routes. Experimental reproductive effects. Human mutation data reported. Explodes at room temperature. Can detonate with (KOH + CHzCh). When heated to decomposition it emits toxic fumes of NOx.
Carcinogenicity
N-Nitroso-N-methylurea is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
There is no evidence that MNU has ever been produced or used commercially; therefore, no data from human case reports or epidemiological studies are available. MNU is available in small quantities for research purposes and may be released into the environment with laboratory waste. In air, MNU is expected to exist solely as a vapor with an estimated vapor pressure of 2.9×10-2 mmHg at 25℃. Vapor-phase MNU is expected to degrade in the atmosphere by reaction with photochemically produced hydroxyl radicals with an estimated half-life of 10 days. MNU is expected to hydrolyze in moist soils; therefore, MNU adsorption and volatilization from soil are not expected to be prevalent. In water,MNUis expected to hydrolyze and has a halflife of 1.2 h at pH 7 and 20℃; therefore, volatilization, adsorption into suspended solids and sediments, biodegradation, and bioconcentration are not expected to be important processes in aquatic systems. Occupational exposure to MNU may occur through oral contact, inhalation, and/or dermal contact at workplaces where it is used as a research chemical. Potential exposure may occur during the preparation and administration ofMNUor during clean up. To avoid spills,MNU should be transported in securely sealed glass bottles or ampules, which should themselves be placed inside strong screw-cap or snap-top containers that will not open when dropped. Both bottle and the outside container should be appropriately labeled.
Toxicity evaluation
MNU is a direct-acting alkylating agent that interacts with DNA to yield a variety of reaction products. The predominant adduct (70–90%) is at the nucleophilic position 7 of guanine, yielding 7-methyldeoxyguanosine (7-medGua). While 7-medGua does not appear to be directly mutagenic, the presence of 7-medGua in susceptible tissues and cells can be used as a marker of recent exposure to methylating agents such as MNU, because it is more stable than mutagenic O6-medGua. Alterations in DNA structure that are left unrepaired may lead to an accumulation of mutations and eventually enhance cancer risk. When the DNA damage is very severe, MNU may act as a cytotoxic agent and cause cell death.
1-Methyl-1-nitrosourea Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Methyl-1-nitrosourea manufacturers
- Product
- 1-Methyl-1-nitrosourea 684-93-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2021-03-19
- Product
- 1-Methyl-1-nitrosourea 684-93-5
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-16