CHOLESTEROL-5ALPHA,6ALPHA-EPOXIDE
- Product Name
- CHOLESTEROL-5ALPHA,6ALPHA-EPOXIDE
- CAS No.
- 1250-95-9
- Chemical Name
- CHOLESTEROL-5ALPHA,6ALPHA-EPOXIDE
- Synonyms
- cholesteroloxide;epoxycholesterol;Cholesterolepoxide;5β-Epoxycholesterol;5,6-epoxy Cholestanol;cholesterolalpha-oxide;ALPHA-EPOXYCHOLESTEROL;5a,6a-Epoxycholesterol;-9a,11b-dimethyl-9-((R);5α,6α-epoxy Cholestanol
- CBNumber
- CB5109966
- Molecular Formula
- C27H46O2
- Formula Weight
- 402.65
- MOL File
- 1250-95-9.mol
CHOLESTEROL-5ALPHA,6ALPHA-EPOXIDE Property
- Melting point:
- 147 °C
- Boiling point:
- 464.74°C (rough estimate)
- Density
- 0.9932 (rough estimate)
- refractive index
- 1.4480 (estimate)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 10 mg/ml) orin Ethanol (up to 10 mg/ml).
- form
- solid
- pka
- 15.20±0.70(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Safety
- WGK Germany
- 3
- RTECS
- FZ6360000
N-Bromosuccinimide Price
- Product number
- C2773
- Product name
- Cholesterol 5α,6α-epoxide
- Packaging
- 50mg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- 25539
- Product name
- 5α,6α-epoxy Cholestanol
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 25539
- Product name
- 5α,6α-epoxy Cholestanol
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 25539
- Product name
- 5α,6α-epoxy Cholestanol
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- 25539
- Product name
- 5α,6α-epoxy Cholestanol
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $301
- Updated
- 2024/03/01
CHOLESTEROL-5ALPHA,6ALPHA-EPOXIDE Chemical Properties,Usage,Production
Description
5α,6α-Epoxycholesterol (1250-95-9) is a naturally occurring metabolite of cholesterol.? It is a major oxysterol found in processed food1?and has been implicated in atherosclerosis2,3. 5α,6α-Epoxycholesterol has been found to be an endogenous ligand for LXR (EC50?= 76 nM).4
Uses
Cholesterol 5alpha,6alpha-epoxide is used in the generation of oxysterols and in the studies of the biological significance of oxysterols.
Uses
Cholesterol 5α, 6α-epoxide was incorporated in culture medium of human arterial endothelial cells to study oxysterol-induced toxicity.
Uses
5α,6α-epoxycholestanol has been used as a sterol internal standard in ultra-performance liquid chromatography–high resolution mass spectrometry (UPLC-ESI-HRMS) analysis to quantify mice brain sterols. It may be used in calibration curve generation for the quantification of phytosterols in food samples and as an internal standard for oxysterol quantification in biological samples by gas chromatography-mass spectrometry (GC-MS)
Definition
ChEBI: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol is a 3beta-hydroxy steroid, an oxysterol and an epoxy steroid. It derives from a hydride of a 5alpha-cholestane.
General Description
5α,6α-epoxycholestanol (5α,6α-EC) is generated by cholesterol epoxidation and is a diastereoisomer of 5β,6β-epoxycholestanol (5β,6β-EC).
Biochem/physiol Actions
Cholesterol 5α, 6α-epoxide is an oxysterol, a cholesterol derivative by auto-oxidation. Oxysterols are non-genomic regulators of cholesterol homeostasis. The biological effects include protein prenylation, apoptosis, modulation of sphingolipid metabolism and platelet aggregation. Oxysterols bind to liver X receptors, modulate cholesterol efflux and decrease the uptake of cholesterol by the cells.
References
1) Leonarduzzi?et al.?(2002),?Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effect (review);?J.?Nutr. Biochem.,?13?700 2) Bj?rkhem?et al. (1988),?Assay of unesterified cholesterol-5,6-epoxide in human serum by isotope dilution mass spectrometry. Levels in the healthy state and in hyperlipoproteinemia; J. Lipid Res.,?29?1031 3) Staprans?et al.?(2005),?The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis; Mol. Nutr. Food Res.,?49?1075 4) Berrodin?et al. (2010),?Identification of 5α,6α-Epoxycholesterol as a novel modulator of Liver X Receptor; Mol. Pharmacol.,?78?1046
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View Lastest Price from CHOLESTEROL-5ALPHA,6ALPHA-EPOXIDE manufacturers
- Product
- Cholesterol-5alpha,6alpha-epoxide 1250-95-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 10000KG
- Release date
- 2024-08-09