ChemicalBook > CAS DataBase List > (2S, 1'R)/(2S, 1'S)-2-Amino-6-(1'-carboxy-ethylamino)-he xanoic acid

(2S, 1'R)/(2S, 1'S)-2-Amino-6-(1'-carboxy-ethylamino)-he xanoic acid

Product Name
(2S, 1'R)/(2S, 1'S)-2-Amino-6-(1'-carboxy-ethylamino)-he xanoic acid
CAS No.
5746-03-2
Chemical Name
(2S, 1'R)/(2S, 1'S)-2-Amino-6-(1'-carboxy-ethylamino)-he xanoic acid
Synonyms
CEL (>70% purity);Loratadine Impurity 71;Nε-(Carboxyethyl)lysine;N-6-(Carboxyethyl)-L-lysine;N(6)-(1-carboxyethyl)lysine;Nε-(1-Carboxyethyl)-L-lysine;L-Lysine, N6-(1-carboxyethyl)-;N-[(5S)-5-amino-5-carboxypentyl]-DL-alanine;(2S)-2-amino-6-(1-carboxyethylamino)hexanoic acid;Nμ-(1-Carboxyethyl)-L-lysine\n(Mixture of Diastereomers)
CBNumber
CB51112970
Molecular Formula
C9H18N2O4
Formula Weight
218.25
MOL File
5746-03-2.mol
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(2S, 1'R)/(2S, 1'S)-2-Amino-6-(1'-carboxy-ethylamino)-he xanoic acid Property

Boiling point:
427.7±45.0 °C(Predicted)
Density 
1?+-.0.06 g/cm3(Predicted)
solubility 
Water: Slightly Soluble
form 
A solid
pka
2.30±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25333
Product name
Nε-(1-Carboxyethyl)-L-lysine
Purity
≥95%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
25333
Product name
Nε-(1-Carboxyethyl)-L-lysine
Purity
≥95%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
25333
Product name
Nε-(1-Carboxyethyl)-L-lysine
Purity
≥95%
Packaging
10mg
Price
$301
Updated
2024/03/01
TRC
Product number
C178070
Product name
Nε-(1-Carboxyethyl)-L-lysine(MixtureofDiastereomers)
Packaging
10mg
Price
$160
Updated
2021/12/16
Iris Biotech GmbH
Product number
HAA2940
Product name
CEL
Packaging
50mg
Price
$270
Updated
2021/12/16
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(2S, 1'R)/(2S, 1'S)-2-Amino-6-(1'-carboxy-ethylamino)-he xanoic acid Chemical Properties,Usage,Production

Description

Nε-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end product (AGE) produced by the reaction of methyl glyoxal with lysine residues in proteins. Protein bound, but not free, CEL binds to the receptor for AGEs (RAGE). CEL levels are elevated in the lens of diabetic patients with cataract. Long-term caloric restriction decreases CEL levels in rat heart mitochondria. It decreases glutamate uptake and secretion of S100B in rat hippocampal slices in a RAGE-independent manner when used at a concentration of 1 mM.

Uses

CEL and CML are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions.

Definition

ChEBI: N(6)-(1-carboxyethyl)-L-lysine is a L-lysine derivative formed during the reaction between methylglyoxal and protein. CEL is a homologue of N(epsilon)-(carboxymethyl)lysine (CML), an advanced glycation end-product that is formed on reaction of glyoxal or glycolaldehyde with protein and on oxidative cleavage of fructoselysine, the Amadori adduct formed on glycation of protein by glucose. It is a L-lysine derivative and a non-proteinogenic L-alpha-amino acid.

(2S, 1'R)/(2S, 1'S)-2-Amino-6-(1'-carboxy-ethylamino)-he xanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S, 1'R)/(2S, 1'S)-2-Amino-6-(1'-carboxy-ethylamino)-he xanoic acid Suppliers

Canada 1 China 14 India 1 United States 2 Global 18
Shanghai Macklin Biochemical Co.,Ltd.
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shenlinxing@macklin.cn
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China
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021-64609169 18901607656
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Energy Chemical
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TargetMol Chemicals Inc.
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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5746-03-2, (2S, 1'R)/(2S, 1'S)-2-Amino-6-(1'-carboxy-ethylamino)-he xanoic acidRelated Search:

NE-CARBOXYMETHYL-L-LYSINE (2S, 1'R)/(2S, 1'S)-2-Amino-6-(1'-carboxy-ethylamino)-he xanoic acid

  • N(6)-(1-carboxyethyl)lysine
  • CEL (>70% purity)
  • Nε-(1-Carboxyethyl)-L-lysine
  • Nμ-(1-Carboxyethyl)-L-lysine\n(Mixture of Diastereomers)
  • (2S, 1'R)/(2S, 1'S)-2-Amino-6-(1'-carboxy-ethylamino)-he xanoic acid
  • L-Lysine, N6-(1-carboxyethyl)-
  • N-6-(Carboxyethyl)-L-lysine
  • (2S)-2-amino-6-(1-carboxyethylamino)hexanoic acid
  • Loratadine Impurity 71
  • N-[(5S)-5-amino-5-carboxypentyl]-DL-alanine
  • Nε-(1-Carboxyethyl)-L-lysine_x000b_(Mixture of Diastereomers)
  • Nε-(Carboxyethyl)lysine
  • 5746-03-2