1-Boc-azetidine-2-carboxylic acid methyl ester
Uses- Product Name
- 1-Boc-azetidine-2-carboxylic acid methyl ester
- CAS No.
- 255882-72-5
- Chemical Name
- 1-Boc-azetidine-2-carboxylic acid methyl ester
- Synonyms
- 1-Boc-Azetidine-2-carboxy...;Methyl 1-Boc-azetidine-2-carboxylate;Methyl N-Boc-Azetidine-2-carboxylate;tert-butyl methyl azetidine-1,2-dicarboxylate;1-tert-Butyl-2-methylazetidin-1,2-dicarboxylat;1-TERT-BUTYL METHYL AZETIDINE-1,2-DICARBOXYLATE;O1-tert-Butyl O2-methyl azetidine-1,2-dicarboxylate;1-O-tert-butyl 2-O-methyl azetidine-1,2-dicarboxylate;O1-tert-Butyl O2-methyl azetidine-1,2-dicarboxylate - [B0733];1,2-Azetidinedicarboxylicacid, 1-(1,1-dimethylethyl) 2-methy...
- CBNumber
- CB51116837
- Molecular Formula
- C10H17NO4
- Formula Weight
- 215.25
- MOL File
- 255882-72-5.mol
1-Boc-azetidine-2-carboxylic acid methyl ester Property
- Boiling point:
- 269.0±33.0 °C(Predicted)
- Density
- 1.152±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -3.46±0.40(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- 068936
- Product name
- O1-tert-Butyl O2-methyl azetidine-1,2-dicarboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $57
- Updated
- 2021/12/16
- Product number
- FB149360
- Product name
- 1-Boc-azetidine-2-carboxylic acid methylester
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 4H58-1-8Y
- Product name
- 1-Boc-azetidine-2-carboxylic acid, methyl ester
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FB149360
- Product name
- 1-Boc-azetidine-2-carboxylic acid methylester
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- CS-B0648
- Product name
- 1-Boc-azetidine-2-carboxylicacidmethylester
- Packaging
- 5g
- Price
- $148
- Updated
- 2021/12/16
1-Boc-azetidine-2-carboxylic acid methyl ester Chemical Properties,Usage,Production
Uses
Azacyclic butane-2-carboxylic acid has been used in the preparation of many inhibitors, such as liver fibrosis inhibitors and algal growth inhibitors. Furthermore, azacyclic butane-2-carboxylic acid also has important applications in many asymmetric synthetic fields.
Synthesis
67-56-1
159749-28-7
255882-72-5
Isobutyl chloroformate (8.43 g, 61.7 mmol) was slowly added to a solution of anhydrous THF (20 mL) containing N-Boc-azetidine-2-carboxylic acid (12.42 g, 61.7 mmol) and N-methylmorpholine (6.23 g, 61.7 mmol) under nitrogen protection, and the rate of addition was controlled to maintain a reaction temperature of less than -8 °C. After addition, the reaction mixture was stirred at -8 °C for 1 hour, then brought to room temperature and continued stirring for 3 hours. Methanol (200 mL) was added to the reaction solution and stirred at room temperature for 18 hours. Upon completion of the reaction, the volatile components were removed by distillation under reduced pressure and the residue was partitioned with water and diethyl ether. The organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the oily product methyl N-Boc-2-azetidinecarboxylate (11.15 g, 84.0% yield). The product was confirmed by NMR hydrogen spectrum (CDCl3): δ 1.43 (s, 9H), 2.20 (m, 1H), 2.50 (m, 1H), 3.78 (s, 3H), 3.90 (m, 1H), 4.00 (m, 1H), 4.60 (m, 1H).
References
[1] Patent: WO2006/100461, 2006, A1. Location in patent: Page/Page column 79
1-Boc-azetidine-2-carboxylic acid methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-Boc-azetidine-2-carboxylic acid methyl ester manufacturers
- Product
- 1-Boc-azetidine-2-carboxylic acid methyl ester 255882-72-5
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 1kg; 5kg
- Release date
- 2020-02-03