Hepronicate
- Product Name
- Hepronicate
- CAS No.
- 7237-81-2
- Chemical Name
- Hepronicate
- Synonyms
- Megrin;Hepronicate;1,1,1-Heptanetriyltris(methanol)tris(nicotinate);1,1,1-Heptanetriyltris(methanol) tris(nicotinate);2-Hydroxymethyl-2-hexyl-1,3-propanediol trinicotinate;Bis(nicotinic acid)2-hexyl-2-(nicotinoyloxymethyl)-1,3-propanediyl ester;3-Pyridinecarboxylic acid, 1,1'-[2-hexyl-2-[[(3-pyridinylcarbonyl)oxy]methyl]-1,3-propanediyl] ester
- CBNumber
- CB51117157
- Molecular Formula
- C28H31N3O6
- Formula Weight
- 505.56
- MOL File
- 7237-81-2.mol
Hepronicate Property
- Melting point:
- 94-96°
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
N-Bromosuccinimide Price
- Product number
- API0002898
- Product name
- HEPRONICATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.21
- Updated
- 2021/12/16
Hepronicate Chemical Properties,Usage,Production
Originator
Megrin,Yoshitomi,Japan,1972
Definition
ChEBI: Hepronicate is an organic molecular entity.
Manufacturing Process
In 50 ml of pyridine were dissolved 50 grams of nicotinic acid and 50 grams of p-toluene-sulfonyl chloride. While stirring, the mixture gradually became hot and colorless, and finally solidified. To the mixture was added dropwise a solution of 19 grams of 2-hexyl-2-(hydroxymethyl)-1,3-propanediol in 400 ml of pyridine at a temperature below 80°C. The mixture was heated at 115° to 125°C on an oil bath for 1 hour. After cooling, the mixture was poured into 300 ml of ice water, and extracted with toluene. The toluene layer was washed in sequence with water, aqueous sodium carbonate and water, dried over potassium carbonate, and then the toluene was distilled off. The oily residue was crystallized from ethanol to give 30 grams of 2-hexyl-2-(hydroxymethyl)- 1,3-propanediol trinicotinate, melting at 94° to 96°C. The yield was 59.5%.
Therapeutic Function
Vasodilator
Hepronicate Preparation Products And Raw materials
Raw materials
Preparation Products
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