D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
- Product Name
- D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
- CAS No.
- 205524-46-5
- Chemical Name
- D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
- Synonyms
- idone-5-carboxyL;Glutamic Acid Impurity 21;tert-butyl D-Pyroglutamate;tert-butyl 5-oxo-D-prolinate;5-Oxo-D-proline tert-butyl ester;D-PyroglutaMic acid ter-butyl ester;2-Methyl-2-propanyl 5-oxo-D-prolinate;D-PYROGLUTAMIC ACID TERT-BUTYL ESTER;5-oxo-D-Proline1,1-dimethylethyl ester;tert-Butyl (R)-2-Pyrrolidone-5-carboxylate
- CBNumber
- CB51119313
- Molecular Formula
- C9H15NO3
- Formula Weight
- 185.22
- MOL File
- 205524-46-5.mol
D-PYROGLUTAMIC ACID TERT-BUTYL ESTER Property
- Boiling point:
- 319℃
- Density
- 1.099
- Flash point:
- 147℃
- storage temp.
- 2-8°C
- pka
- 14.65±0.40(Predicted)
- Appearance
- White to off-white Solid
- optical activity
- Consistent with structure
- InChI
- InChI=1S/C9H15NO3/c1-9(2,3)13-8(12)6-4-5-7(11)10-6/h6H,4-5H2,1-3H3,(H,10,11)/t6-/m1/s1
- InChIKey
- QXGSPAGZWRTTOT-ZCFIWIBFSA-N
- SMILES
- C(OC(C)(C)C)(=O)[C@H]1CCC(=O)N1
Safety
- HS Code
- 2933790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 287633
- Product name
- D-Pyroglutamic acid tert-butyl ester
- Packaging
- 1g
- Price
- $425
- Updated
- 2021/12/16
- Product number
- AS25088
- Product name
- tert-Butyl (R)-2-Pyrrolidone-5-carboxylate
- Purity
- 97+% ee
- Packaging
- 1g
- Price
- $43
- Updated
- 2021/12/16
- Product number
- AS25088
- Product name
- tert-Butyl (R)-2-Pyrrolidone-5-carboxylate
- Purity
- 97+% ee
- Packaging
- 5G
- Price
- $86
- Updated
- 2021/12/16
- Product number
- 4H29-1-R1
- Product name
- tert-Butyl (2R)-5-oxopyrrolidine-2-carboxylate
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
- Product number
- 075055
- Product name
- tert-Butyl 5-oxo-D-prolinate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $92
- Updated
- 2021/12/16
D-PYROGLUTAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Synthesis
540-88-5
4042-36-8
205524-46-5
The general procedure for the synthesis of tert-butyl D-pyroglutamate from tert-butyl acetate and D-(+)-pyroglutamic acid was as follows: (R)-5-oxopyrrolidine-2-carboxylic acid (3.21 g, 24.9 mmol) was dissolved in tert-butyl acetate (100 mL) under argon protection. Subsequently, 60% aqueous perchloric acid (1.5 mL) was slowly added at room temperature. The reaction mixture was stirred at room temperature for 24 hours in an argon atmosphere. Upon completion of the reaction, saturated aqueous sodium bicarbonate solution (50 mL) was added to the mixture to neutralize the reaction solution, followed by extraction with chloroform (3 x 30 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and the solvent was removed by distillation under reduced pressure to afford tert-butyl (R)-5-oxopyrrolidine-2-carboxylate (4.62 g, yield) as a white solid. The physical properties of the product are described below.
References
[1] Chemistry - A European Journal, 2016, vol. 22, # 27, p. 9330 - 9337
[2] Patent: JP6095208, 2017, B2. Location in patent: Paragraph 0036-0038
D-PYROGLUTAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from D-PYROGLUTAMIC ACID TERT-BUTYL ESTER manufacturers
- Product
- D-PYROGLUTAMIC ACID TERT-BUTYL ESTER 205524-46-5
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-07-26