Pneumocandin B0
- Product Name
- Pneumocandin B0
- CAS No.
- 135575-42-7
- Chemical Name
- Pneumocandin B0
- Synonyms
- CFA;Pneumocardin B0;Caspofungin PneuMocandin B0 IMpurity;CS-492;L-688786;CFA/ CBR01;CHEMBL269311;Novocontin B0;neumocandin B0;PneumocandinBo
- CBNumber
- CB51120636
- Molecular Formula
- C50H80N8O17
- Formula Weight
- 1065.21
- MOL File
- 135575-42-7.mol
Pneumocandin B0 Property
- Melting point:
- >230°C (dec.)
- Boiling point:
- 1442.9±65.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Sparingly)
- pka
- 9.86±0.26(Predicted)
- form
- Solid
- color
- White to Off-White
- λmax
- 276nm(MeOH)(lit.)
- InChIKey
- DQXPFAADCTZLNL-PYWTXGKPNA-N
Safety
- HS Code
- 2941.90.3000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
H400Very toxic to aquatic life
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P285In case of inadequate ventilation wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P391Collect spillage. Hazardous to the aquatic environment
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P2534
- Product name
- Pneumocandin B0
- Purity
- >96.0%(HPLC)
- Packaging
- 10mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- P2534
- Product name
- Pneumocandin B0
- Purity
- >96.0%(HPLC)
- Packaging
- 50mg
- Price
- $369
- Updated
- 2024/03/01
- Product number
- 21527
- Product name
- Pneumocandin B0
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21527
- Product name
- Pneumocandin B0
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 21527
- Product name
- Pneumocandin B0
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $116
- Updated
- 2024/03/01
Pneumocandin B0 Chemical Properties,Usage,Production
Description
Pneumocandin B0 is an antifungal lipopeptide that acts by inhibiting the synthesis of β-(1,3)-D-glucan, a component of fungal cell walls (IC50s = 70 and 67 ng/ml for inhibiting glucan synthase in C. albicans and A. fumigatus, respectively). It can be used to synthesize the echinocandin caspofungin acetate .
Uses
Pneumocandin B0 is the major analogue of a family of lipopeptides isolated from several species of several different genera, such as Cryptosporiopsis, Glarea and Pezicula. Pneumocandin B0 is a potent antifungal and acts by inhibition of the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.
Definition
ChEBI: An echinocandin initially isolated as a very minor bioactive fermentation product of Glarea lozoyensis (originally known as Zalerion arboricola). Subsequent random mutagenesis work and optimisation of the fermentation medium permi ted the industrial production of pneumocandin B0, which is used as the starting point for the synthesis of the antifungal drug caspofungin.
Biosynthesis
Pneumocandin B0 (PB0), the precursor of the antifungal drug caspofungin, is a secondary metabolite of the fungus G. lozoyensis, and its biosynthesis is affected by the types and concentrations of nutrients in the medium. Acetyl-CoA and NADPH were identified as the main factors limiting pneumocandin B0 biosynthesis. Other metabolites, such as pyruvate, α-ketoglutaric acid, lactate, unsaturated fatty acids, and previously unreported metabolite γ-aminobutyric acid, were shown to play important roles in pneumocandin B0 biosynthesis and cell growth. The carbon source is a crucial factor affecting cell growth and PB0 production. Transcriptome analysis showed that when G. lozoyensis was cultured with fructose as the carbon source, the expression of genes in the PB0 synthetic gene cluster was downregulated. At the same time, the PB0 yield was increased by 54.76%. When fructose was used as the carbon source, PPP, glycolysis, and branched-chain amino acid metabolism of G. lozoyensis were promoted, which may have provided more NADPH and acetyl-CoA for biosynthesis. Furthermore, the downregulation of the PB0 biosynthesis gene cluster and the TCA cycle resulted in more acetyl-CoA for fatty acid synthesis[3–4].
General Description
Pneumocandin B0, the precursor of the antifungal drug caspofungin, is a lipohexapeptide produced by the fungus Glarea lozoyensis. Oxidative stress and the resulting reactive oxygen species (ROS) are involved in regulating the biosynthesis of it. Acetyl-CoA and NADPH are major factors limiting the biosynthesis of pneumocandin B0. Other metabolites, such as pyruvate, α-ketoglutaric acid, lactate, unsaturated fatty acids, and metabolite γ-aminobutyric acid, also play an important role in the biosynthesis of pneumocandin B0 and cell growth[1-2].
Mechanism of action
Pneumocandin B0 is a potent antifungal and acts by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.
Solubility in organics
Pneumocandin B0 is soluble in ethanol, methanol, DMF and DMSO.
References
[1] Dong Y, et al. Glyap1 regulates pneumocandin B0 synthesis by controlling the intracellular redox balance in Glarea lozoyensis. Applied Microbiology and Biotechnology, 2021; 105: 6707–6718.
[2] Song P, et al. Metabolomics profiling reveals the mechanism of increased pneumocandin B0 production by comparing mutant and parent strains. Journal of Industrial Microbiology Biotechnology, 2018; 45: 767–780.
[3] Ke Zhang. Comparative Transcriptomics Analysis of the Responses of the Filamentous Fungus Glarea lozoyensis to Different Carbon Sources. Frontiers in Microbiology (2020): 190.
[4] Ping Song. Metabolomics profiling reveals the mechanism of increased pneumocandin B0 production by comparing mutant and parent strains. Journal of Industrial Microbiology Biotechnology 45 9 (2018): 767–780.
Pneumocandin B0 Preparation Products And Raw materials
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View Lastest Price from Pneumocandin B0 manufacturers
- Product
- Pneumocandin B0 135575-42-7
- Price
- US $999.00-666.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-20
- Product
- pneumocandin b0 135575-42-7
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-09
- Product
- Pneumocandin B0 135575-42-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 95%min
- Supply Ability
- 50kg
- Release date
- 2021-11-02