N-(n-Nonyl)deoxynojirimycin

Product Name: N-(n-Nonyl)deoxynojirimycin
CAS No.: 81117-35-3
Chemical Name: N-(n-Nonyl)deoxynojirimycin
Synonyms: Nonyl-DNJ;N-Nonyldeoxynojirimycin;N-(n-Nonyl)-1-deoxynojirimycin;N-(n-Nonyl)-1-deoxynojirimycin min. 99%;(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol;(2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol;3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-nonyl-, (2R,3R,4R,5S)-
CBNumber: CB51176507
Molecular Formula: C15H31NO4
Formula Weight: 289.41
MOL File: 81117-35-3.mol

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N-(n-Nonyl)deoxynojirimycin Property

Melting point:: 101-102°C
Boiling point:: 451.7±45.0 °C(Predicted)
Density: 1.112±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >10mg/mL
form: solid
pka: 13.72±0.70(Predicted)

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H319Causes serious eye irritation
Precautionary statements: P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N6414
Product name: NN-DNJ
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $229
Updated: 2024/03/01

Sigma-Aldrich

Product number: N6414
Product name: NN-DNJ
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $880
Updated: 2024/03/01

Cayman Chemical

Product number: 29698
Product name: N-Nonyldeoxynojirimycin
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 29698
Product name: N-Nonyldeoxynojirimycin
Packaging: 25mg
Price: $469
Updated: 2024/03/01

Cayman Chemical

Product number: 29698
Product name: N-Nonyldeoxynojirimycin
Packaging: 5mg
Price: $155
Updated: 2024/03/01

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N-(n-Nonyl)deoxynojirimycin Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Definition

ChEBI: N-nonyldeoxynojirimycin is a hydroxypiperidine that is deoxynojirimycin (duvoglustat) in which the amino hydrogen is replaced by a nonyl group. It has a role as an EC 3.2.1.45 (glucosylceramidase) inhibitor, an EC 3.2.1.20 (alpha-glucosidase) inhibitor and an antiviral agent. It is a hydroxypiperidine and a tertiary amino compound. It is functionally related to a duvoglustat.

Biological Activity

Glucosidase inhibitor (IC 50 values are 0.42 and 8.4 μ M for acid α -glucosidase and α -1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo . Also acts as a chemical chaperone; chaperones β -Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.

Biochem/physiol Actions

NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity.

storage

Store at -20°C

N-(n-Nonyl)deoxynojirimycin Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(n-Nonyl)deoxynojirimycin Suppliers

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81117-35-3, N-(n-Nonyl)deoxynojirimycinRelated Search:

N-Dodecyldeoxynojirimycin N-CYCLOHEXYLPROPYL DEOXYNOJIRIMYCIN, HYDROCHLORIDE N-CYCLOHEXYLPROPYL DEOXYNOJIRIMYCIN N-(n-Nonyl)deoxynojirimycin

(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol

N-(n-Nonyl)-1-deoxynojirimycin min. 99%

N-Nonyldeoxynojirimycin

N-(n-Nonyl)-1-deoxynojirimycin

Nonyl-DNJ

3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-nonyl-, (2R,3R,4R,5S)-

(2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonylpiperidine-3,4,5-triol

81117-35-3

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