Amadinone

Product Name
Amadinone
CAS No.
30781-27-2
Chemical Name
Amadinone
Synonyms
6-Chloro-17-hydroxy-19-norpregna-4,6-diene-3,20-dione;19-Norpregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-
CBNumber
CB51177988
Molecular Formula
C20H25ClO3
Formula Weight
348.86
MOL File
30781-27-2.mol
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Amadinone Property

Boiling point:
509.5±50.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
pka
12.86±0.60(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
SHG0005782
Product name
AMADINONE
Purity
95.00%
Packaging
5MG
Price
$495.52
Updated
2021/12/16
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Amadinone Chemical Properties,Usage,Production

Originator

Amadinone,ZYF Pharm Chemical

Uses

Progestin.

Manufacturing Process

A solution of 250.0 mg of δ4-3,20-dioxo-6α,7α-oxido-17α-acetoxy-19- norpregnene in 15 ml of 1 N hydrochloric acid in dioxan is kept for 1 h at 25°C, then poured into water and neutralized with sodium bicarbonate solution. The precipitated crude product is dissolved in a 5:1 mixture of ether and methylene chloride, washed with water until the washings run neutral, and the solution is dried and evaporated under vacuum to give the δ4-3,20- dioxo-6-chloro-7α-hydroxy-17α-acetoxy-19-nor-pregnene.
The crude δ4-3,20-dioxo-6-chloro-7α-hydroxy-17α-acetoxy-19-nor-pregnene is dissolved in 3 ml of pyridine, mixed at 5°-0°C with 0.3 ml of methanesulphonyl chloride while being stirred, and the mixture is kept for 2 days at 10°C. The reaction product is then poured into dilute sodium bicarbonate solution, dissolved in ether, and the ethereal solution is washed until the washings run neutral, dried and evaporated under vacuum and the δ4-3,20-dioxo-6-chloro-7α-mesyloxy-17α-acetoxy-19-norpregnene is obtained.
The δ4-3,20-dioxo-6-chloro-7α-mesyloxy-17α-acetoxy-19-norpregnene is dissolved in 25 ml of dimethyl formamide, mixed with 4.5 g of anhydrous sodium acetate, and the whole is heated for 75 min at 85°C under nitrogen while being stirred. The cooled reaction mixture is diluted with water, extracted with a 5:1-mixture of ether and methylene chloride, and the organic layer is washed with 100 ml of water, dried and evaporated. The resulting crude product is dissolved in benzene and chromatographed on 15 times its own weight of alumina (activity II). The afore-mentioned solvent elates 105.0 mg of pure δ4,6-3,20-dioxo-6-chloro-17α-acetoxy-19-norpregnadiene, melting point 159°-161°C (recrystallized from methylene chloride:hexane).
The δ4,6-3,20-dioxo-6-chloro-17-hydroxy-19-norpregnadien, melting point 159°-161°C, may be produced by hydrolysis of δ4,6-3,20-dioxo-6-chloro-17α- acetoxy-19-norpregnadiene.

Therapeutic Function

Progestin

Amadinone Preparation Products And Raw materials

Raw materials

Preparation Products

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Amadinone Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
TargetMol Chemicals Inc.
Tel
15002134094
Email
marketing@targetmol.cn
Country
China
ProdList
19704
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58

30781-27-2, AmadinoneRelated Search:


  • 6-Chloro-17-hydroxy-19-norpregna-4,6-diene-3,20-dione
  • 19-Norpregna-4,6-diene-3,20-dione, 6-chloro-17-hydroxy-
  • 30781-27-2