Hazard and Precautionary Statements (GHS)

Amcinafide Chemical Properties,Usage,Production

Originator

Amcinafide,Onbio Inc.

Uses

Anti-inflammatory.

Manufacturing Process

1 ml 72% perchloric acid was added to a suspension of 4 g triamcinolone in 100 ml of fresh distilled acetophenone and the mixture was stirred at a room temperature before all triamcinolone solved (for about 2 hours). The solution was neutralized with help of 8 ml of 1.1 N sodium hydroxide and sufficient quantity of sodium bicarbonate. Then chloroform and water were added. Organic layer was separated and concentrated in vacuum. The residue was recrystallized from acetone-hexane and thoroughly washed from acetophenone with hexane. Triamcinolone acetophenide (amicinafide) was prepared. It had MP: 281°-283°C (decomp.);αD 23 = +23°. (c = 0.98 in CHCl3).

Therapeutic Function

Antiinflammatory, Antiallergic