Nitracrine
- Product Name
- Nitracrine
- CAS No.
- 4533-39-5
- Chemical Name
- Nitracrine
- Synonyms
- Nitracrine;3-(dimethylamino)propyl-(1-nitroacridin-9-yl)amine;N',N'-dimethyl-N-(1-nitroacridin-9-yl)propane-1,3-diamine;1,3-Propanediamine, N1,N1-dimethyl-N3-(1-nitro-9-acridinyl)-
- CBNumber
- CB51179326
- Molecular Formula
- C18H20N4O2
- Formula Weight
- 324.382
- MOL File
- 4533-39-5.mol
Nitracrine Property
- Melting point:
- 134-135°
- Boiling point:
- 462.71°C (rough estimate)
- Density
- 1.2155 (rough estimate)
- refractive index
- 1.6700 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- pKa1 6.45; pKa2 8.8(at 25℃)
- form
- Solid
- color
- Brown to reddish brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- API0009151
- Product name
- NITRACRINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.93
- Updated
- 2021/12/16
- Product number
- CSN21764
- Product name
- Nitracrine
- Packaging
- 1mg
- Price
- $408
- Updated
- 2021/12/16
- Product number
- CSN21764
- Product name
- Nitracrine
- Packaging
- 10mg
- Price
- $1387
- Updated
- 2021/12/16
Nitracrine Chemical Properties,Usage,Production
Uses
Nitracrine inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine, a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor agent. Nitracrine has cytotoxicity towards most cells[1][2][3].
Definition
ChEBI: Nitracrine is a member of acridines.
References
[1] Wilson WR, et al. Selective toxicity of nitracrine to hypoxic mammalian cells. Br J Cancer. 1984 Feb;49(2):215-23. DOI:10.1038/bjc.1984.34
[2] Gniazdowski M, et al. Nitracrine and its congeners--an overview. Gen Pharmacol. 1995 May;26(3):473-81. DOI:10.1016/0306-3623(94)00143-b
[3] Daghastanli NA, et al. Cytotoxicity of nitroheterocyclic compounds, quinifuryl and nitracrine, towards leukaemic and normal cells on the dark and under illumination with visible light. J Photochem Photobiol B. 2004 Jul 19;75(1-2):27-32. DOI:10.1016/j.jphotobiol.2004.04.005
Nitracrine Preparation Products And Raw materials
Raw materials
Preparation Products
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