ChemicalBook > CAS DataBase List > Zongertinib

Zongertinib

Product Name: Zongertinib
CAS No.: 2728667-27-2
Chemical Name: Zongertinib
Synonyms: BI-1810631;Zongertinib;Zostertinib;BLU-451(LNG451);Toremifen citrate;Zostertinib BI-1810631;Zongertinib/BI 1810631;azol-5-yl)oxy]phenyl]amino]pyrimido[5,4-d]pyrimidin-2-yl]-4-piperidinyl]-;N-[1-[4-[3-methyl-4-(1-methylbenzimidazol-5-yl)oxy-anilino]pyrimido[5,4-d]pyrimidin-6-yl]-4-piperidyl]prop-2-enamide;N-(1-(8-((3-methyl-4-((1-methyl-1H-benzo[d]imidazol-5-yl)oxy)phenyl)amino)pyrimido[5,4-d]pyrimidin-2-yl)piperidin-4-yl)acrylamide
CBNumber: CB512094450
Molecular Formula: C29H29N9O2
Formula Weight: 535.6
MOL File: 2728667-27-2.mol

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Zongertinib Property

Density: 1.39±0.1 g/cm3(Predicted)
form: Solid
pka: 14.16±0.20(Predicted)
color: Light yellow to green yellow
InChIKey: YSGNGFPNTLERCR-UHFFFAOYSA-N
SMILES: C(NC1CCN(C2=NC=C3N=CN=C(NC4=CC=C(OC5=CC=C6N(C)C=NC6=C5)C(C)=C4)C3=N2)CC1)(=O)C=C

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Hazard and Precautionary Statements (GHS)

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Zongertinib Chemical Properties,Usage,Production

Description

Zongertinib (also known as BI 1810631) is an investigational irreversible tyrosine kinase inhibitor (TKI) that selectively inhibits HER2 (ERBB2) while inhibiting epidermal growth factor receptor (EGFR), thereby limiting associated toxicity. This oral targeted therapy is being developed for the treatment of advanced non-small cell lung cancer (NSCLC) with HER2 (ERRB2) mutations.

Uses

Zongertinib (BI 1810631) is a potent and selective HER2 and EGFR tyrosine kinase inhibitor with IC50 values of 13 nM and 579 nM, respectively. Zongertinib has antitumor activity and can be used in the study of multiple solid tumors[1][2][3].

References

[1] WHO Drug Informat ion - World Health Organization (WHO).
[2] Wilding Birgit, et al. Synthesis of diazino-pyrimidines as anticancer agents: World Intellectual Property Organization, WO2021213800. 2021-10-28.
[3] Li S, et al. Emerging Targeted Therapies in Advanced Non-Small-Cell Lung Cancer. Cancers (Basel). 2023 May 24;15(11):2899. DOI:10.3390/cancers15112899

Zongertinib Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Zongertinib manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Zongertinib; BI-1810631 2728667-27-2
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 99% HPLC
Supply Ability: 10000
Release date: 2024-09-19

2728667-27-2, ZongertinibRelated Search:

2-Propenamide, N-[1-[8-[[3-methyl-4-[(1-methyl-1H-benzimidazol-5-yl)oxy]phenyl]amino]pyrimido[5,4-d]pyrimidin-2-yl]-4-piperidinyl]-

N-[1-[4-[3-methyl-4-(1-methylbenzimidazol-5-yl)oxy-anilino]pyrimido[5,4-d]pyrimidin-6-yl]-4-piperidyl]prop-2-enamide

Zongertinib

N-(1-(8-((3-methyl-4-((1-methyl-1H-benzo[d]imidazol-5-yl)oxy)phenyl)amino)pyrimido[5,4-d]pyrimidin-2-yl)piperidin-4-yl)acrylamide

BI-1810631

Zongertinib/BI 1810631

BLU-451(LNG451)

Toremifen citrate

azol-5-yl)oxy]phenyl]amino]pyrimido[5,4-d]pyrimidin-2-yl]-4-piperidinyl]-

Zostertinib

Zostertinib BI-1810631

N-{1-[8-({3-methyl-4-[(1-methyl-1H-1,3-benzodiazol-5-yl)oxy]phenyl}amino)-[1,3]diazino[5,4-d]pyrimidin-2-yl]piperidin-4-yl}prop-2-enamide

2728667-27-2

C29H29N9O2

API