Romifidine hydrochloride

Product Name: Romifidine hydrochloride
CAS No.: 65896-14-2
Chemical Name: Romifidine hydrochloride
Synonyms: Sedivet;STH 2130Cl;Romifidine HCl;Romifidine Hydrochloride;Romifidine Hydrochloride, Monohydrochloride;N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-ylamine HCl;N-(2-BroMo-6-fluorophenyl)-4,5-dihydro-1H-iMidazol-2-aMine Hydrochloride;1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-, monohydrochloride;1H-Imidazol-2-amine, N-(2-bromo-6-fluorophenyl)-4,5-dihydro-, hydrochloride (1:1)
CBNumber: CB51210096
Molecular Formula: C9H10BrClFN3
Formula Weight: 0
MOL File: 65896-14-2.mol

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Romifidine hydrochloride Property

storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White
InChI: InChI=1S/C9H9BrFN3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
InChIKey: SDXVSIWCVTYYQN-UHFFFAOYSA-N
SMILES: C1(NC2=C(F)C=CC=C2Br)NCCN=1.[H]Cl

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: R640050
Product name: RomifidineHydrochloride
Packaging: 50mg
Price: $350
Updated: 2021/12/16

TRC

Product number: R640050
Product name: RomifidineHydrochloride
Packaging: 100mg
Price: $670
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007049
Product name: ROMIFIDINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 50MG
Price: $721.88
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0007049
Product name: ROMIFIDINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 25MG
Price: $323.4
Updated: 2021/12/16

Ambeed

Product number: A1061990
Product name: N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-aminehydrochloride
Purity: 98+%
Packaging: 1g
Price: $564
Updated: 2021/12/16

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Romifidine hydrochloride Chemical Properties,Usage,Production

Description

Romifidine hydrochloride [N-(2-b romifidineo-6-fluoro-phenyl)- 4,5-dihydro-1H-imidazol-2-amine mono-hydrochloride, C9H9BrFN3, MW 258.1; romifidine] is an imidazole derivative with potent a2-adrenoceptor agonist properties. It is commonly used in equine practice to provide sedation, analgesia, and muscle relaxation. A comparative study reported that an intravenous (i.v.) dose of 80 μg/kg romifidine is equipotent to 1 mg/kg xylazine i.v. and 20 μg/kg detomidine i.v.[1]. Typical signs of sedation include muscle relaxation, decreased head height (HH), diminished responsiveness to external stimuli, and postural abnormalities following romifidine administration. Furthermore, romifidine possesses antinociceptive activity. As an analgesic, it reduces anesthetic requirements for isoflurane in horses.

Uses

An α2 agonist use as a sedative and analgesic.

Uses

As an α2 agonist used as a sedative and analgesic, RoMifidine Hydrochloride is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses.

Mechanism of action

Alpha2 agonists decrease release of neurotransmitters from the neuron. The proposed mechanism whereby they decrease transmission is via binding to presynaptic alpha2 receptors (negative feedback receptors).

References

[1] M. WOJTASIAK-WYPART. “Pharmacokinetic profile and pharmacodynamic effects of romifidine hydrochloride in the horse.” Journal of veterinary pharmacology and therapeutics 35 5 (2012): 478–488.

Romifidine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Romifidine hydrochloride Suppliers

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65896-14-2

C9H10BrClFN3

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