TETRAETHYLAMMONIUM (META)PERIODATE Property

Melting point:

~170 °C (dec.)

solubility 

sol H2O, MeCO2H, acetone, pyridine, CH2Cl2; slightly sol alcohol; insol ethyl acetate, Et2O, benzene.

form 

crystals

BRN 

4166132

Safety

Hazard Codes 

F

Risk Statements 

11

Safety Statements 

16

RIDADR 

UN 1325 4.1/PG 2

WGK Germany 

3

HazardClass 

4.1

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H228Flammable solid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

TETRAETHYLAMMONIUM (META)PERIODATE Chemical Properties,Usage,Production

Uses

Tetraethylammonium (meta)periodate can be used as an oxidant in the N-dealkylation of tertiary amines using Fe(III) complex as a catalyst. It can also be employed as a reagent in the intramolecular cycloaddition reactions.

Application

Tetraethylammonium Periodate is used as an oxidizing agent used for generating nitroso compounds from hydroxamic acids, N-hydroxycarbamic esters, and N-hydroxyureas.

Preparation

Preparative Methods of Tetraethylammonium Periodate: a solution of periodic acid (H5IO6) (7.72 g, 0.034 mol) in water (20 mL) was added slowly to a cooled solution of 25% tetraethylammonium hydroxide (20 mL, 0.034 mol). The resulting solution was evaporated under reduced pressure, the solid residue was extracted with hot t-butyl alcohol, and the product was precipitated by addition of diisopropyl ether. Recrystallization from t-butyl alcohol yielded a white solid (8.5 g, 82%).
Caution: a safety shield should be used since any excess H5IO6 present may explode violently during concentration of the aqueous solution and extraction of the crude salt.

reaction suitability

reagent type: oxidant

storage

Tetraethylammonium (meta)periodate is stable and is best stored in a desiccator in the dark.