ChemicalBook > CAS DataBase List > (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid

(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid

Product Name: (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid
CAS No.: 5130-29-0
Chemical Name: (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid
Synonyms: Cholic Acid Impurity 9;12-Ketodeoxycholic acid;5β-CHOLANIC acid-3α-OL-12-ONE;BAA485 (12-Ketodeoxycholic acid);12-Ketodeoxycholic acid, 10 mM in DMSO;3-ALPHA-HYDROXY-12-OXO-5-BETA-CHOLANOICACID;Cholan-24-oic acid, 3-hydroxy-12-oxo-, (3α,5β)-;Cholic Acid IMpurity (3-alpha-Hydroxy-12-Oxo-5-beta-Cholanoic Acid);(4R)-4-((3R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;(R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-12-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
CBNumber: CB51235330
Molecular Formula: C24H38O4
Formula Weight: 390.56
MOL File: 5130-29-0.mol

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(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid Property

Melting point:: 165-167 °C
Boiling point:: 545.9±35.0 °C(Predicted)
Density: 1.124±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
form: A solid
pka: 4.74±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00913
Product name: BAA485 (12-Ketodeoxycholic acid)
Purity: ≥95% (HPLC)
Packaging: 25MG
Price: $228
Updated: 2025/07/31

Cayman Chemical

Product number: 29547
Product name: 12-keto Lithocholic Acid
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 29547
Product name: 12-keto Lithocholic Acid
Packaging: 50mg
Price: $388
Updated: 2024/03/01

Cayman Chemical

Product number: 29547
Product name: 12-keto Lithocholic Acid
Packaging: 10mg
Price: $124
Updated: 2024/03/01

Cayman Chemical

Product number: 29547
Product name: 12-keto Lithocholic Acid
Packaging: 25mg
Price: $214
Updated: 2024/03/01

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(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid Chemical Properties,Usage,Production

Description

12-keto Lithocholic acid is a metabolite of the secondary bile acid deoxycholic acid (DCA; Item Nos. 20756 | 18231). Fecal levels of 12-keto lithocholic acid are elevated in rats fed a diet supplemented with cholic acid or DCA compared with rats fed a control diet or a diet supplemented with cholesterol , hyodeoxycholic acid (HDCA; ), or lithocholic acid (LCA; ). 12-keto Lithocholic acid activates the human pregnane X receptor (PXR; EC₅₀ = 31.3 μM in a cell-based transactivation assay). 12-keto Lithocholic acid levels are increased in duodenal bile from patients with type 2 diabetes.

Uses

12-Ketodeoxycholic acid (12-Ketolithocholic acid) is a bile acid, metabolite from kidney. 12-Ketodeoxycholic acid can be a detectable marker for evidence of kidney injury[1]

Definition

ChEBI: 12-ketolithocholic acid is a bile acid.

References

[1] Chen H, et al. Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression.Redox Biol. 2016 Dec;10:168-178. DOI:10.1016/j.redox.2016.09.014

(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid Preparation Products And Raw materials

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View Lastest Price from (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 12-Ketodeoxycholic acid 5130-29-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-10

5130-29-0, (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acidRelated Search:

Butyrylcholinesterase Obeticholic Acid

(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxo-1,2,3,4,5,6,7,8,9,11,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid

12-Ketodeoxycholic acid

3-ALPHA-HYDROXY-12-OXO-5-BETA-CHOLANOICACID

Cholic Acid IMpurity (3-alpha-Hydroxy-12-Oxo-5-beta-Cholanoic Acid)

(4R)-4-((3R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-12-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

Cholic Acid Impurity 9

5β-CHOLANIC acid-3α-OL-12-ONE

(R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-12-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

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Cholan-24-oic acid, 3-hydroxy-12-oxo-, (3α,5β)-

12-Ketodeoxycholic acid, 10 mM in DMSO

BAA485 (12-Ketodeoxycholic acid)

5130-29-0