3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one

Product Name: 3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one
CAS No.: 34834-67-8
Chemical Name: 3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one
Synonyms: Ccris 7628;Hydroxycotinine;trans-3’-Hydroxycotini;trans-3'-Hydroxy Cotinine;-Hydroxycotinine (cis-3’trans-3’-Hydroxycotinine solution;(3'R,5'S)-trans-3'-Hydroxynicotinine;trans-3'-Hydroxy Cotinine (1.0 Mg/ML in Methanol);3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one;3-Hydroxy-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone
CBNumber: CB51236009
Molecular Formula: C10H12N2O2
Formula Weight: 192.21
MOL File: 34834-67-8.mol

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3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one Property

Melting point:: 107-109°C
Boiling point:: 416.5±45.0 °C(Predicted)
Density: 1.275±0.06 g/cm3(Predicted)
Flash point:: 9℃
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
pka: 13.02±0.40(Predicted)
color: White to off-white

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Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 16-36/37-45
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H370Causes damage to organs

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H-101
Product name: trans-3’-Hydroxycotinine solution
Purity: 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $131
Updated: 2022/05/15

Cayman Chemical

Product number: 16100
Product name: trans-3'-Hydroxycotinine
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 16100
Product name: trans-3'-Hydroxycotinine
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 16100
Product name: trans-3'-Hydroxycotinine
Purity: ≥98%
Packaging: 10mg
Price: $330
Updated: 2024/03/01

TRC

Product number: H924500
Product name: trans-3''-HydroxyCotinine
Packaging: 25mg
Price: $395
Updated: 2021/12/16

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3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one Chemical Properties,Usage,Production

Description

trans-3’-Hydroxycotinine (3HC) is a product of CYP2A6 metabolism of the primary nicotine metabolite, cotinine . Cotinine has a longer metabolic half-life compared to 3HC (16 hours vs. 5 hours). The ratio of 3HC to cotinine, termed the nicotine metabolite ratio, correlates with nicotine clearance from the body and is used as a biomarker of CYP2A6 activity. This measure of nicotine metabolism has been used to study tobacco and secondhand smoke exposure as well as to develop pharmacological intervention strategies for smoking cessation.

Chemical Properties

Off-White to Pale-Yellow Solid

Uses

A metabolite of Nicotine. Carcinogen.

Uses

trans-3''-Hydroxy Cotinine is a metabolite of Nicotine (N412450, (S)-(-)-Nicotine).

Definition

ChEBI: An N-alkylpyrrolidine that is cotinine substituted at position C-3 by a hydroxy group (the 3R,5S-diastereomer).

General Description

Trans-3′-Hydroxycotinine is a major nicotine metabolite excreted in the urine of smokers and users of other tobacco or nicotine products including cigars, chewing tobacco and snuff. This Certified Spiking Solution^? is suitable for use in nicotine testing methods or clinical and diagnostic testing of nicotine biomarkers by LC-MS/MS or GC/MS.

3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one Suppliers

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34834-67-8, 3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-oneRelated Search:

Sulfanilamide

3-hydroxy-1-methyl-5-pyridin-3-yl-pyrrolidin-2-one

Hydroxycotinine

(3R,5S)-1-Methyl-3-hydroxy-5-(3-pyridyl)pyrrolidine-2-one

(3R,5S)-3-Hydroxy-1-methyl-5-(3-pyridinyl)pyrrolidin-2-one

(3'R,5'S)-trans-3'-Hydroxynicotinine

3-Hydroxy-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone

Ccris 7628

(3R,5S)-3-Hydroxy-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone

trans-3'-Hydroxy Cotinine (1.0 Mg/ML in Methanol)

trans-3’-Hydroxycotinine solution

-Hydroxycotinine (cis-3&rsquo

2-Pyrrolidinone, 3-hydroxy-1-methyl-5-(3-pyridinyl)-, (3R,5S)-

(+)-TRANS-3'-HYDROXYCOTININE UNLABELED 100 UG/ML IN ACETONITRILE

trans-3’-Hydroxycotini

trans-3'-Hydroxy Cotinine

34834-67-8

Chiral Reagents, Heterocycles, Metabolites & Impurities, Nicotine Derivatives, Mutagenesis Research Chemicals

Chiral Reagents

Heterocycles

Metabolites & Impurities

Mutagenesis Research Chemicals

Nicotine Derivatives