ChemicalBook > CAS DataBase List > 2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid

2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid

Product Name: 2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid
CAS No.: 516-50-7
Chemical Name: 2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid
Synonyms: Taurodesoxycholic Acid;Tudcabil;Deoxycholyltaurine;Taurodoxcholicacid;Apigenine Impurity 3;Deoxytaurocholic Acid;Taurodeoxychloic Acid;Taurine deoxycholic acid;Taurosulfodeoxycholic acid;Taurodesoxycholic Acid(TDCA)
CBNumber: CB51236276
Molecular Formula: C26H45NO6S
Formula Weight: 499.7
MOL File: 516-50-7.mol

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2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid Property

Melting point:: 175-200 °C
Density: 1.216±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated, Sonicated)
form: Solid
pka: 1.42±0.50(Predicted)
color: White to Off-White
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: BBF0000260
Product name: TAURODEOXYCHOLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $496.3
Updated: 2021/12/16

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2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid Chemical Properties,Usage,Production

Uses

Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.

Definition

ChEBI: A bile acid taurine conjugate of deoxycholic acid.

in vivo

Taurodeoxycholic acid (1.25-5 mg/kg, p.o., 6 days) ameliorates dextran sodium sulfate (DSS)-induced colitis in mice^[9].
Taurodeoxycholic acid (Taurodeoxycholic acid form, 50 mg/kg; i.p.; once daliy for 34 d) prevents neuropathology and associated behavioral deficits in the 3-nitropropionic acid rat model of Huntington's disease (HD) ^[10].
Taurodeoxycholic acid (Taurodeoxycholic acid form, 500 mg/kg; s.c.; once every 3 d for 7 weeks) leads to a significant reduction in striatal neuropathology of the R6/2 transgenic HD mouse^[11].
Taurodeoxycholic acid (0.5 mg/kg; i.v., once) confers protection to C57BL/6N mice with sepsis, but does not protect TGR5 KO mice under sepsis^[12].

Animal Model:	A mouse colitis model (fed with 3% (w/v) DSS in drinking water for the first seven days and then switched to normal drinking water for an additional two days)^[9]
Dosage:	1.25, 2.5, and 5 mg/kg
Administration:	Oral gavage (p.o.), from day 3 to day 8, once a day
Result:	Prevented loss of body weight, shortening of the colon, production of pro-inflammatory cytokines, infiltration of pro-inflammatory cells, and mucosal ulceration in the colon.

Animal Model:	Huntington's disease model in mouse^[10]
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection; once daliy for 34 d, injected 3-NP at 6 hr after Taurodeoxycholic acid treatment
Result:	Reduced striatal atrophy, decreased striatal apoptosis, as well as fewer and smaller size ubiquitinated neuronal intranuclear huntingtin inclusions. Significantly improved locomotor and sensorimotor deficits.

Animal Model:	C57BL/6N mice, Lipopolysaccharides (HY-D1056) injection model of sepsis^[12]
Dosage:	0.5 mg/kg
Administration:	Intravenous injection, 30 min or 24 h after LPS injection
Result:	Improved the survival rate of mice with sepsis. Decreased liver and kidney damage in septic mice. Ameliorated systemic inflammation and normalized blood pressure in septic mice.

IC 50

Microbial Metabolite

2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid Preparation Products And Raw materials

Raw materials

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View Lastest Price from 2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD

Product: 2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid 516-50-7
Price: US $3.00/kg
Min. Order: 1kg
Purity: 99.99
Supply Ability: 10000
Release date: 2025-06-05

Shaanxi Xianhe Biotech Co., Ltd

Product: Taurodeoxycholic acid 516-50-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-04-21

516-50-7, 2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acidRelated Search:

Taurohyodeoxycholic acid sodium salt hydrate taurohyodeoxycholic acid Taurohyodeoxycholic Acid-d5 Taurohyodeoxycholic Acid Sodium Salt-d5 2-[[(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl]amino]ethanesulfonic acid Taurohyodeoxycholic Acid Sodium Salt Impurity 1 Tauroursodeoxycholic acid

2-[[(3a,5,12)-3,12-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic Acid

Deoxycholyltaurine

Deoxytaurocholic Acid

N-(3a,12a-Dihydroxy-5-cholan-24-oyl)taurine

Taurodeoxychloic Acid

Taurodesoxycholic Acid

Tudcabil

2-[[(3α,5β,12α)-3,12-Dihydroxy-24-oxocholan-24-yl]amino]ethanesulfonic acid

N-(2-Sulfoethyl)-3α,12α-dihydroxy-5β-cholan-24-amide

Taurodeoxychloic Acid Discontinued See T009005

2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid

Ethanesulfonic acid, 2-[[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]amino]-

2-((R)-4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)ethanesulfonic acid

Taurodeoxycholic Acid MaxSpec? Standard

Taurodeoxycholic Acid Discontinued See T009005

Taurosulfodeoxycholic acid

Taurodesoxycholic Acid(TDCA)

Taurodeoxycholic Acid Monomer

Taurine isoursodeoxycholic acid

Taurine deoxycholic acid

Apigenine Impurity 3

Taurodoxcholicacid

Taurodeoxycholic Acid (solution in methanol) Standard

516-50-7

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