ChemicalBook > CAS DataBase List > BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT

BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT

Product Name: BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT
CAS No.: 71730-64-8
Chemical Name: BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT
Synonyms: THR-SER-LYS;H-Thr-Ser-Lys-OH;thr-ser-lys acetate;threonyl-seryl-lysine;Thr-Ser-Lys acetate salt;H-THR-SER-LYS-OH ACETATE SALT;threonine-serine-lysine acetate;THR-SER-LYS (THR-SER-LYS ACETATE);L-Lysine, N2-(N-L-threonyl-L-seryl)-;BOVINE PINEAL ANTIREPRODUCTIVE PEPTIDE
CBNumber: CB5123834
Molecular Formula: C13H26N4O6
Formula Weight: 334.37
MOL File: 71730-64-8.mol

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BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT Property

storage temp.: -15°C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB109446
Product name: Bovine Pineal Antireproductive Tripeptide acetate salt H-Thr-Ser-Lys-OH acetate salt
Packaging: 25mg
Price: $121
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB109446
Product name: Bovine Pineal Antireproductive Tripeptide acetate salt H-Thr-Ser-Lys-OH acetate salt
Packaging: 50mg
Price: $210
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB109446
Product name: Bovine Pineal Antireproductive Tripeptide acetate salt H-Thr-Ser-Lys-OH acetate salt
Packaging: 100mg
Price: $365
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb364438
Product name: Bovine Pineal Antireproductive Peptide
Purity: > 95%
Packaging: 5mg
Price: $552.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BIO0000067
Product name: ANTIREPRODUCTIVE TRIPEPTIDE
Purity: 95.00%
Packaging: 50MG
Price: $709.46
Updated: 2021/12/16

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BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT Chemical Properties,Usage,Production

Uses

Threonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5[1][3].

Definition

ChEBI: Thr-Ser-Lys is an oligopeptide.

in vivo

Threonyl-seryl-lysine (175 ng, i.p.) reduces the 5-day compensatory ovarian hypertrophy in unilaterally ovariectomized (UO) mice^[1].
Threonyl-seryl-lysine (1 or 5 μg, i.p.) delays vaginal opening time in female Charles River CD rats^[2].
Threonyl-seryl-lysine (1 and 10 μg, s.c., for 15 days) increases the weight of ovaries and of adrenals in mice^[4].

Animal Model:	Unilaterally ovariectomized (UO) mice
Dosage:	175 ng
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced serum follicle stimulating hormone (FSH) in UO mice.

References

[1] Orts RJ, et al. Inhibitory properties of a bovine pineal tripeptide, threonylseryllysine, on serum follicle-stimulating hormone. Neuroendocrinology. 1980 Aug;31(2):92-5. DOI:10.1159/000123056
[2] Benson B. Bovine pineal tripeptide threonylseryllysine retards puberty in female rats. J Pineal Res. 1989;6(4):351-7. DOI:10.1111/j.1600-079x.1989.tb00431.x
[3] Root-Bernstein RS, et al. Bovine pineal antireproductive tripeptide binds to luteinizing hormone-releasing hormone: a model for peptide modulation by sequence specific peptide interactions? Brain Res Bull. 1986 Oct;17(4):519-28. DOI:10.1016/0361-9230(86)90219-4
[4] Vaughan M K, et al. Influence of Thr-Ser-Lys (TSL), a recently isolated pineal peptide, on ovarian and uterine weights and estrous cycles in mice, hamsters and rats. Pineal function (Mathews CD, Seamark RF, eds.), 1981: 165-172.

BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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71730-64-8, BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALTRelated Search:

H-GLY-NLE-OH GLYCYL-DL-NORLEUCINE H-SER-GLY-OH H-GLY-SER-ALA-OH H-SER-ALA-OH H-ALA-NLE-OH AC-NLE-OH AC-LYS-OH ANTIREPRODUCTIVE TRIPEPTIDE DL-ALANYL-DL-NORLEUCINE AC-SER-GLY-OH H-THR-NHME BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT

THR-SER-LYS

BOVINE PINEAL ANTIREPRODUCTIVE PEPTIDE

BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE

BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT

H-THR-SER-LYS-OH ACETATE SALT

H-Thr-Ser-Lys-OH

thr-ser-lys acetate

threonyl-seryl-lysine

THR-SER-LYS (THR-SER-LYS ACETATE)

threonine-serine-lysine acetate

L-Lysine, N2-(N-L-threonyl-L-seryl)-

Thr-Ser-Lys acetate salt

Bovine Pineal Antireproductive Tripeptide acetate salt H-Thr-Ser-Lys-OH acetate salt

(2S)-6-amino-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]hexanoic acid

71730-64-8

C13H26N4O6