Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-
- Product Name
- Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-
- CAS No.
- 170858-33-0
- Chemical Name
- Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)-
- Synonyms
- U 101387;PNU 101387;PF-05191680;PNU-101387G;Sonepiprazole;Sonepiprazole hydrate;Sonepiprazole, 10 mM in DMSO;inhibit,Dopamine Receptor,U-101387G,Sonepiprazole,PNU-101387G,Inhibitor;4-[4-[2-[(1S)-Isochroman-1-yl]ethyl]piperazin-1-yl]benzenesulfonamide hydrate;(S)-4-[4-[2-(3,4-Dihydro-1H-2-benzopyran-1-yl)ethyl]-1-piperazinyl]benzenesulfonaMide
- CBNumber
- CB51245409
- Molecular Formula
- C21H27N3O3S
- Formula Weight
- 401.52
- MOL File
- 170858-33-0.mol
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Property
- storage temp.
- room temp
- solubility
- DMSO: >10mg/mL
- form
- powder
- color
- white to off-white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- PZ0174
- Product name
- Sonepiprazole hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- PZ0174
- Product name
- Sonepiprazole hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $426
- Updated
- 2024/03/01
- Product number
- 11983
- Product name
- Sonepiprazole
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 11983
- Product name
- Sonepiprazole
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 11983
- Product name
- Sonepiprazole
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $193
- Updated
- 2024/03/01
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Chemical Properties,Usage,Production
Description
Sonepiprazole is a selective antagonist of the dopamine 4 (D4) receptor (Kis = 10 nM). It is highly selective over D1, D2, and D3 receptors, serotonin 1A and 2 receptors, as well as α1- and α2-adrenergic receptors (Kis > 2,000 nM). Its safety profile in rat studies is improved in comparison to classical antipsychotics but it is not effective for positive or negative symptoms of schizophrenia in patients. In a pharmacological model of stress exposure in rhesus monkeys, sonepiprazole reverses stress-induced cognitive deficits.
Uses
Sonepiprazole is a dopamine D4 antagonist with Ki=10 nM.
storage
Store at +4°C
References
[1] K M MERCHANT. Pharmacological characterization of U-101387, a dopamine D4 receptor selective antagonist.[J]. Journal of Pharmacology and Experimental Therapeutics, 1996, 279 3: 1392-1403.
[2] RUTH E. TENBRINK. (S)-(?)-4-[4-[2-(Isochroman-1-yl)ethyl]piperazin-1-yl]benzenesulfonamide, a Selective Dopamine D4 Antagonist[J]. Journal of Medicinal Chemistry, 1996, 39 13: 2435-2437. DOI: 10.1021/jm960084f
[3] MARK H CORRIGAN . Effectiveness of the selective D4 antagonist sonepiprazole in schizophrenia: a placebo-controlled trial[J]. Biological Psychiatry, 2004, 55 5: Pages 445-451. DOI: 10.1016/j.biopsych.2003.10.004
[4] AMY F T ARNSTEN PH.D Beth M M, PH.D Kalpana M Ph D. The Selective Dopamine D4 Receptor Antagonist, PNU-101387G, Prevents Stress-Induced Cognitive Deficits in Monkeys[J]. Neuropsychopharmacology, 2000, 23 4: 405-410. DOI: 10.1016/s0893-133x(00)00133-0
Benzenesulfonamide, 4-(4-(2-(3,4-dihydro-1H-2-benzopyran-1-yl)ethyl)-1 -piperazinyl)-, (S)- Preparation Products And Raw materials
Raw materials
Preparation Products
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