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Didemnin B

Product Name
Didemnin B
CAS No.
77327-05-0
Chemical Name
Didemnin B
Synonyms
Didemnin B;Didemnin A, N-[1-[(2S)-2-hydroxy-1-oxopropyl]-L-prolyl]-;N-(L-Lac-L-Pro-N-Methyl-D-Leu-)cyclo[L-Thr*-[(3S,4R)-3-hydroxy-4-[(S)-1-methylpropyl]-γAbu-]-[(2S,4S)-4-hydroxy*-2,5-dimethyl-3-oxohexanoyl]-L-Leu-L-Pro-N,O-dimethyl-L-Tyr-]
CBNumber
CB51247302
Molecular Formula
C57H89N7O15
Formula Weight
1112.36
MOL File
77327-05-0.mol
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Didemnin B Property

Boiling point:
821.94°C (rough estimate)
Density 
1.0596 (rough estimate)
refractive index 
1.6910 (estimate)
storage temp. 
Store at -20°C
solubility 
Acetonitrile: 1 mg/ml
form 
A crystalline solid
pka
11.28±0.70(Predicted)
color 
White to off-white
optical activity
-82.0622 (CHCl3)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0028325
Product name
DIDEMNIN B
Purity
95.00%
Packaging
5MG
Price
$458.64
Updated
2021/12/16
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Didemnin B Chemical Properties,Usage,Production

Description

Didemnin B is a cyclic depsipeptide extracted from the Caribbean tunicate Trididemnum cyanophorum. Didemnin B activates caspase, inducing apoptosis and preventing eukaryotic elongation factor 2 (eEF-2)-dependent translocation, inhibiting protein synthesis. This agent also has immunosuppressive and antiviral properties. It is an effective immunosuppressive agent. It is approximately 1,000 times more effective than the standard cyclosporin A. Further study may prove it useful in repressing rejections of transplanted organs[1].

Definition

ChEBI: A natural product found particularly in Lyngbya majuscula and Trididemnum solidum.

Biological Activity

Didemnin B belongs to a group of cyclic depsipeptides produced by Trididemnum solidum Van Name and provides a unique lactylprolin unit in the side chain of the molecule. The natural product interacts with the 80S ribosome, thereby retaining eEF1α in the ribosomal complex despite exhibiting proper GTP hydrolysis. Consequently, eEF2 binding to the ribosome and subsequent eEF2-dependent tRNA translocation are prevented. Didemnin B only shows sufficient binding affinity to the ribosome-eEF1α-complex and not to eEF1α alone. The natural product has antiviral properties and is cytotoxic against both cancerous and normal mammalian cells, whereby highly proliferating cells are more strongly affected than resting cells[2].

in vitro

Didemnin B has activity against miirine B16 melanoma, P388 leukemia, and M5076 sarcoma.

in vivo

Didemnin B is a potent inhibitor of L1210 growth.

References

[1] Renneberg, R. Viola Berkling and V. Loroch. “Chapter 7 – Green Biotechnology.”Biotechnology for Beginners (Third Edition) (2023): 241-290.
[2] Luisa D. Burgers , Robert Fürst. “Natural products as drugs and tools for influencing core processes of eukaryotic mRNA translation.” Pharmacological research 170 (2021): Article 105535.

Didemnin B Preparation Products And Raw materials

Raw materials

Preparation Products

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Didemnin B Suppliers

Fuxin Pharmaceutical
Tel
021-50872116 13611907556
Fax
021-31300828
Email
contact@fuxinpharm.com
Country
China
ProdList
1596
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58
T&W GROUP
Tel
021-61551611 13296011611
Fax
+86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7887
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56
Taizhou KEDE Chemical Co., Ltd
Tel
0576-84613060 13093829633
Fax
0576-84613060
Email
sales@kedechemical.com
Country
China
ProdList
298
Advantage
60
Shanghai Biolang biotechnology Co.,Ltd
Tel
17764003753
Fax
13669031409
Email
2326587775@qq.com
Country
China
ProdList
188
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55
Shanghai Biolang biotechnology Co.,Ltd
Tel
17764003753
Fax
13669031409
Email
2326587775@qq.com
Country
China
ProdList
188
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55
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6463
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Wellman Pharmaceutical Group Limited
Tel
027-027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
4009
Advantage
58
Henan Alfa Chemical Co., Ltd
Tel
+86-18339805032; +8618339805032
Email
alfa4@alfachem.cn
Country
China
ProdList
13227
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58

77327-05-0, Didemnin BRelated Search:


  • Didemnin B
  • N-(L-Lac-L-Pro-N-Methyl-D-Leu-)cyclo[L-Thr*-[(3S,4R)-3-hydroxy-4-[(S)-1-methylpropyl]-γAbu-]-[(2S,4S)-4-hydroxy*-2,5-dimethyl-3-oxohexanoyl]-L-Leu-L-Pro-N,O-dimethyl-L-Tyr-]
  • Didemnin A, N-[1-[(2S)-2-hydroxy-1-oxopropyl]-L-prolyl]-
  • 77327-05-0
  • C57H89N7O15