ChemicalBook > CAS DataBase List > 4-Methoxy-pyridin-2-ol

4-Methoxy-pyridin-2-ol

Product Name
4-Methoxy-pyridin-2-ol
CAS No.
52545-13-8
Chemical Name
4-Methoxy-pyridin-2-ol
Synonyms
4-Methoxypyridin-2-ol;4-METHOXY-2(1H)-PYRIDINONE;4-Methoxypyridi;Gimeraux impurities1;4-Methoxy-2-pyridone;4-Methoxypyridin-2(1H);4-methoxy-1H-pyridin-2-one;2(1H)-Pyridinone, 4-methoxy-;2(1H)-Pyridinone,4-methoxy-(9CI);4-Methoxy-1,2-dihydropyridin-2-one
CBNumber
CB51274315
Molecular Formula
C6H7NO2
Formula Weight
125.13
MOL File
52545-13-8.mol
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4-Methoxy-pyridin-2-ol Property

Melting point:
101-102 °C
Boiling point:
355.1±42.0 °C(Predicted)
Density 
1.16±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
11.08±0.10(Predicted)
Appearance
Yellow to brown Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
M336563
Product name
4-Methoxypyridin-2(1H)-one
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
074285
Product name
4-Methoxy-2(1H)-pyridinone
Purity
95+%
Packaging
250mg
Price
$324
Updated
2021/12/16
Matrix Scientific
Product number
074285
Product name
4-Methoxy-2(1H)-pyridinone
Purity
95+%
Packaging
1g
Price
$700
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0078937
Product name
4-METHOXY-2(1H)-PYRIDINONE
Purity
95.00%
Packaging
250MG
Price
$933.24
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0078937
Product name
4-METHOXY-2(1H)-PYRIDINONE
Purity
95.00%
Packaging
1G
Price
$1346.73
Updated
2021/12/16
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4-Methoxy-pyridin-2-ol Chemical Properties,Usage,Production

Synthesis

1122-96-9

52545-13-8

General procedure for the synthesis of 4-methoxy-2-pyridone from 4-methoxypyridine-N-oxide: 4-methoxypyridine-N-oxide (1.5 g, 1.98 mmol) was dissolved in acetic anhydride (45 mL) and heated to reflux overnight under nitrogen protection. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure to remove the acetic anhydride. The residue was diluted with distilled water (15 mL) and methanol (15 mL) and stirred overnight at room temperature. Subsequently, all volatiles were removed and the residue was purified by fast column chromatography (silica gel, dichloromethane/methanol gradient elution, 0 to 10% methanol) to afford 4-methoxy-2-pyridinone (1.1 g, 71% yield) as a brown solid.LC-MS (ESI): m/z [M + H]+ 126.0.

References

[1] Patent: WO2016/4272, 2016, A1. Location in patent: Paragraph 00591
[2] Journal of Organic Chemistry, 2005, vol. 70, # 16, p. 6204 - 6212
[3] Tetrahedron Letters, 1995, vol. 36, # 42, p. 7575 - 7578
[4] Journal of Organic Chemistry, 1999, vol. 64, # 3, p. 950 - 953
[5] Patent: WO2007/48070, 2007, A2. Location in patent: Page/Page column 111

4-Methoxy-pyridin-2-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Methoxy-pyridin-2-ol manufacturers

Career Henan Chemical Co
Product
2(1H)-Pyridinone,4-methoxy-(9CI) 52545-13-8
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-10

52545-13-8, 4-Methoxy-pyridin-2-olRelated Search:

RICININE 4-BENZYLOXY-2(1 H)-PYRIDONE 2-(4-METHOXY-2,3-DIHYDRO-FURO[2,3-B]QUINOLIN-2-YL)-PROPANE-1,2-DIOL 3-chloro-2,4-dimethoxypyridine penclomedine skimmianine N-(([(2-CHLORO-4-FLUOROBENZYL)OXY]IMINO)METHYL)-2-(4-FLUOROPHENOXY)-4-METHOXYNICOTINAMIDE AURORA KA-3527 N-(([(4-FLUOROBENZYL)OXY]IMINO)METHYL)-2-(4-FLUOROPHENOXY)-4-METHOXYNICOTINAMIDE N-(([(2,4-DICHLOROBENZYL)OXY]IMINO)METHYL)-2-(4-FLUOROPHENOXY)-4-METHOXYNICOTINAMIDE AURORA KA-4658 N-[(DIMETHYLAMINO)METHYLENE]-2-(4-FLUOROPHENOXY)-4-METHOXYNICOTINAMIDE AURORA KA-5064 2-(4-FLUOROPHENOXY)-3-(1H-1,2,4-TRIAZOL-3-YL)-4-PYRIDINYL METHYL ETHER AURORA KA-3496 2-(4-FLUOROPHENOXY)-4-METHOXYNICOTINAMIDE N-(([(2,6-DICHLOROBENZYL)OXY]IMINO)METHYL)-2-(4-FLUOROPHENOXY)-4-METHOXYNICOTINAMIDE 3-nitro-4-methoxypyridin-2-ol

  • 2(1H)-Pyridinone,4-methoxy-(9CI)
  • 4-METHOXY-2(1H)-PYRIDINONE
  • 4-Methoxy-2-pyridone4-METHOXY-2(1H)-PYRIDINONE
  • 4-Methoxy-2-pyridone
  • 4-Methoxy-1,2-dihydropyridin-2-one
  • 4-Methoxypyridin-2-ol
  • 4-Methoxypyridin-2(1H)
  • 4-Methoxypyridi
  • 2(1H)-Pyridinone, 4-methoxy-
  • Gimeraux impurities1
  • 4-methoxy-1H-pyridin-2-one
  • 52545-13-8
  • PYRIDINE