2(1H)-Quinoxalinone,3,4-dihydro-3,3-dimethyl-(9CI)

Product Name: 2(1H)-Quinoxalinone,3,4-dihydro-3,3-dimethyl-(9CI)
CAS No.: 80636-30-2
Chemical Name: 2(1H)-Quinoxalinone,3,4-dihydro-3,3-dimethyl-(9CI)
Synonyms: 3,3-dimethyl-1,4-dihydroquinoxalin-2-one;2(1H)-quinoxalinone, 3,4-dihydro-3,3-dimethyl-;3,3-dimethyl-1,2,3,4-tetrahydroquinoxalin-2-one;Quinoxalin-2(1H)-one, 3,4-dihydro-3,3-dimethyl-;2(1H)-Quinoxalinone,3,4-dihydro-3,3-dimethyl-(9CI)
CBNumber: CB51302061
Molecular Formula: C10H12N2O
Formula Weight: 176.22
MOL File: 80636-30-2.mol

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2(1H)-Quinoxalinone,3,4-dihydro-3,3-dimethyl-(9CI) Property

Melting point:: 135-136 °C
Boiling point:: 349.0±31.0 °C(Predicted)
Density: 1.079±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 13.32±0.40(Predicted)
Appearance: White to yellow Solid

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Safety

HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T325759
Product name: 3,3-DIMETHYL-3,4-DIHYDRO-2(1H)-QUINOXALINONE
Purity: AldrichCPR
Packaging: 5MG
Price: $148
Updated: 2025/07/31

TRC

Product number: D456915
Product name: 3,3-Dimethyl-3,4-dihydro-1h-quinoxalin-2-one
Packaging: 100mg
Price: $65
Updated: 2021/12/16

TRC

Product number: D456915
Product name: 3,3-Dimethyl-3,4-dihydro-1h-quinoxalin-2-one
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD120223
Product name: 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one
Packaging: 100mg
Price: $58
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD120223
Product name: 3,3-Dimethyl-3,4-dihydroquinoxalin-2(1H)-one
Packaging: 250mg
Price: $115
Updated: 2021/12/16

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2(1H)-Quinoxalinone,3,4-dihydro-3,3-dimethyl-(9CI) Chemical Properties,Usage,Production

Synthesis Reference(s)

Journal of Medicinal Chemistry, 37, p. 758, 1994 DOI: 10.1021/jm00032a008

Synthesis

95-54-5

57-15-8

80636-30-2

GENERAL PROCEDURE: A representative procedure for the synthesis of 3,3-dimethyl-3,4-dihydroquinoxalin-2(1H)-ones from o-phenylenediamine and trichloro-tert-butanol is as follows: under nitrogen protection, 50% aqueous sodium hydroxide (0.42 mL, 5 equiv.) was added slowly and dropwise to cooled-to-0 °C o-phenylenediamine 1a (200 mg, 1 equiv.), 4-(trichloromethyl)tetrahydro-2H-pyran -4-ol (812 mg, 2 eq.) and N-benzyl-N,N-diethylethanaminium chloride (42 mg, 0.1 eq.) in dichloromethane (0.1 M) in a stirred mixture with a controlled dropwise addition time of 10-20 seconds. The reaction mixture was stirred at 0 °C and then gradually warmed to room temperature and continued stirring for 18 hours. The reaction process was monitored by analytical HPLC-MS. Upon completion of the reaction, the mixture was diluted with water (10 mL) until all solids were dissolved and the layers were subsequently separated. The aqueous layer was extracted with dichloromethane (3 x 20 mL). The organic layers were combined, dried with magnesium sulfate, filtered and the solvent evaporated to give the crude product. The crude product was purified by silica gel column chromatography with an elution gradient of 0-50% ethyl acetate/heptane. The purified solid was filtered through a Brinell funnel and washed with methyl tert-butyl ether (2×10 mL) to give the final 10,2,3,40,5,6-hexahydro-30H-spiro[pyran-4,20-quinoxalin]-30-one (310 mg, 77%) as a pale yellow powder.

References

[1] Tetrahedron Letters, 2016, vol. 57, # 39, p. 4386 - 4388
[2] Synthesis, 1982, # 1, p. 71 - 74

2(1H)-Quinoxalinone,3,4-dihydro-3,3-dimethyl-(9CI) Preparation Products And Raw materials

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Preparation Products

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View Lastest Price from 2(1H)-Quinoxalinone,3,4-dihydro-3,3-dimethyl-(9CI) manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 3,3-Dimethyl-3,4-dihydro-1H-quinoxalin-2-one 80636-30-2
Price: US $2.00-6.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-ton
Release date: 2025-07-28

Career Henan Chemical Co

Product: 2(1H)-Quinoxalinone,3,4-dihydro-3,3-dimethyl-(9CI) 80636-30-2
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

80636-30-2, 2(1H)-Quinoxalinone,3,4-dihydro-3,3-dimethyl-(9CI)Related Search:

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80636-30-2

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