A 71915

Product Name: A 71915
CAS No.: 132956-87-7
Chemical Name: A 71915
Synonyms: A 71915;A-71915TFA;A71915 trifluoroacetate;RC-{Cyclohexyl-Ala}-GGRIDRI-{d-Tic}-RC;(Arg?,β-cyclohexyl-Ala?,D-Tic??,Arg??,Cys??)-Atrial Natriuretic Factor;H-Arg-Cys-b-cyclohexyl-Ala-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-Tic-Arg-Cys-NH2;(Arg?00β-cyclohexyl-Ala?00D-Tic??00Arg??00Cys??)-AtrialNatriureticFactor(6-18)amide(mouse00rabbit00rat);(Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat);(Arg?,β-cyclohexyl-Ala?,D-Tic??,Arg??,Cys??)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat);(Arg6,b-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) aMide (Mouse, rabbit, rat)
CBNumber: CB51325699
Molecular Formula: C69H116N26O15S2
Formula Weight: 1613.95
MOL File: 132956-87-7.mol

More

Less

A 71915 Property

Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 4.00±0.10(Predicted)
form: Solid
color: White to off-white
Water Solubility: Soluble to 1 mg/ml in water
Sequence: Arg-Cys-{Cha}-Gly-Gly-Arg-Ile-Asp-Arg-Ile-{d-Tic}-Arg-Cys-NH2 (Disulfide bridge: Cys2-Cys13)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2908
Product name: A71915 trifluoroacetate
Purity: ≥95% (HPLC)
Packaging: 1MG
Price: $158.65
Updated: 2025/07/31

Tocris

Product number: 6715
Product name: A71915
Packaging: 1
Price: $164
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA108858
Product name: 10H-[1,2,5,8,11,14,17,20,23,26,29,32,35]Dithiaundecaazacyclooctatriacontino[11,10-b]isoquinoline,cyclic peptide deriv
Packaging: 250ug
Price: $255
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA108858
Product name: 10H-[1,2,5,8,11,14,17,20,23,26,29,32,35]Dithiaundecaazacyclooctatriacontino[11,10-b]isoquinoline,cyclic peptide deriv
Packaging: 500ug
Price: $445
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0003888
Product name: A 71915
Purity: 95.00%
Packaging: 5MG
Price: $500.56
Updated: 2021/12/16

More

Less

A 71915 Chemical Properties,Usage,Production

Description

A 71915 is an atrial natricuretic factor receptor antagonist. It blocks physiological effects of angiotensin.

Uses

A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells[1].

in vivo

A 71915 (5 μl; i.m.; 25-30 g male CD-1 mice) affects BNP (1 nmol)- and GRP (0.1 nmol)-induced scratching^[2]. A 71915 (30 μg/ kg/ day) inhibits NS-398 on blood pressure decreased^[3].

Animal Model:	Rat (Male Sprague-Dawley); weighing 150-180 g^[3]
Dosage:	30 μg/kg/day; infused for 3 weeks
Administration:	via a mini-osmotic pump
Result:	The inhibitory effect of NS-398 on blood pressure was attenuated by the pretreatment with A 71915 (30 μg/kg/day).

storage

Store at -20°C

References

[1] Delporte C, et al. Discovery of a potent atrial natriuretic peptide antagonist for ANPA receptors in the human neuroblastoma NB-OK-1 cell line. Eur J Pharmacol. 1992;224(2-3):183-188. DOI:10.1016/0014-2999(92)90803-c
[2] Kiguchi N, et al. Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice. DOI:10.1124/jpet.115.229997
[3] Park BM, et al. Attenuation of renovascular hypertension by cyclooxygenase-2 inhibitor partly through ANP release. Peptides. 2015;69:1-8. DOI:10.1016/j.peptides.2015.03.022

A 71915 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

A 71915 Suppliers

China 47 South Korea 1 United Kingdom 2 United States 4 Global 54

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

Creative Peptides

Tel
Email: info@creative-peptides.com
Country: United States
ProdList: 6083
Advantage: 56

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Nanjing Leon Biological Technology Co., Ltd.

Tel: 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
Country: China
ProdList: 5501
Advantage: 55

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4802
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

132956-87-7, A 71915Related Search:

A 71915

(Arg6,b-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) aMide (Mouse, rabbit, rat)

H-Arg-Cys-b-cyclohexyl-Ala-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-Tic-Arg-Cys-NH2

(Arg,β-cyclohexyl-Ala,D-Tic1,Arg1,Cys1)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat) trifluoroacetate salt

10H-[1,2,5,8,11,14,17,20,23,26,29,32,35]Dithiaundecaazacyclooctatriacontino[11,10-b]isoquinoline,cyclic peptide deriv

RC-{Cyclohexyl-Ala}-GGRIDRI-{d-Tic}-RC

L-Cysteinamide, L-arginyl-L-cysteinyl-3-cyclohexyl-L-alanylglycylglycyl-L-arginyl-L-isoleucyl-L-α-aspartyl-L-arginyl-L-isoleucyl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-arginyl-, cyclic (2→13)-disulfide

(Arg6,β-cyclohexyl-Ala8,D-Tic16,Arg17,Cys18)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat)

A-71915TFA

(Arg?,β-cyclohexyl-Ala?,D-Tic1?,Arg1?,Cys1?)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat) trifluoroacetate salt

(Arg?,β-cyclohexyl-Ala?,D-Tic??,Arg??,Cys??)-Atrial Natriuretic Factor (6-18) amide (mouse, rabbit, rat)

(Arg?,β-cyclohexyl-Ala?,D-Tic??,Arg??,Cys??)-Atrial Natriuretic Factor

A71915 trifluoroacetate

(Arg?00β-cyclohexyl-Ala?00D-Tic??00Arg??00Cys??)-AtrialNatriureticFactor(6-18)amide(mouse00rabbit00rat)

10H-[1,2,5,8,11,14,17,20,23,26,29,32,35]Dithiaundecaazacyclooctatriacontino[11,10-b]isoquinoline,cyclic peptide derivative

132956-87-7

C69H116N26O15S2