Adjudin

ChemicalBook > CAS DataBase List > Adjudin

Product Name: Adjudin
CAS No.: 252025-52-8
Chemical Name: Adjudin
Synonyms: AF-2364;CS-2018;Adjudin;Adjudin, AF-2364;AF-2364;AF 2364;AF2364;1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide;1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide;1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide USP/EP/BP;1-(2,4-Dichloro-benzyl)-1H-indazole-3-carboxylic acid hydrazide;1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid hydrazide
CBNumber: CB51331593
Molecular Formula: C15H12Cl2N4O
Formula Weight: 335.19
MOL File: 252025-52-8.mol

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Adjudin Property

Density: 1.51±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:34.56(Max Conc. mg/mL);103.11(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);89.5(Max Conc. mM)
DMF:PBS (pH 7.2) (1:20):0.05(Max Conc. mg/mL);0.15(Max Conc. mM)
form: A crystalline solid
pka: 11.88±0.30(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22939
Product name: Adjudin
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22939
Product name: Adjudin
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 22939
Product name: Adjudin
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 22939
Product name: Adjudin
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

AK Scientific

Product number: 3333CR
Product name: 1-(2,4-Dichlorobenzyl)-1H-indazole-3-carbohydrazide
Packaging: 25mg
Price: $691
Updated: 2021/12/16

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Adjudin Chemical Properties,Usage,Production

Biological Activity

Adjudin (AF-2364) is an effective male contraceptive and a potent blocker of Cl? channels. It has anti-inflammatory properties by inhibiting NF-κB p65 nuclear translocation and DNA binding activity and ERK MAPK phosphorylation.

in vitro

Adjudin is a potent blocker of Cl ^- channels: disrupting Cl ^- ion transport function results in a decline in sperm capacitation and fertilizing ability in humans in vitro . Adjudin (ADD) is a mitochondria inhibitor. Adjudin is a molecule that mediates adherens junction disruption at the Sertoli-germ cell interface. To investigate the effect of Adjudin on cancer cells, more than ten different types of human or mice cancer cell lines are treated with increasing concentrations of Adjudin and the cell proliferation is measured by the modified MTT assay. Adjudin inhibits cell proliferation in a dose dependent manner in SGC-7901 (human gastric adenocarcinoma cell), MDA-MB-231 (human breast adenocarcinoma cell), Smmc-7721 (human hepatoma cell) and MIA Paca-2 (human pancreatic adenocarcinoma cell) cells. The IC ₅₀ of Adjudin is determined to be 58.0 μM, 13.8 μM, 72.3 μM and 52.7 μM against SGC -7901, MDA-MB-231, Smmc-7721 and MIA Paca-2 cells, res pectively, after treatment for 24 h. Similar results are obtained in other human and mice cancer cell lines. The IC ₅₀ of Adjudin in A549 cells and PC3 cells is 63.1 μM and 93.0 μM, respectively. For WI -38 and BPH-1 cells, the IC ₅₀ of Adjudin can be observed at more than 300 μM and 200 μM, respectively, which is about 5 times and 2 times more than that for the cancer cell lines A549 and PC3.

in vivo

To determine whether Adjudin can inhibit lung and prostate cancer growth in vivo, the effect of Adjudin is tested in a subcutaneous model of lung and prostate cancer. Human lung carcinoma cells A549 and prostate carcinoma cells PC3 are injected into athymic nude mice subdermally at the lower back site respectively. Mice are then randomized into two treatment groups with similar mean tumor sizes: Adjudin and vehicle (control). Approximately 2 weeks after tumor inoculation Adjudin is injected intraperitoneally once every three days in lung carcinoma cells and every other day in prostate carcinoma cells at 100 mg/kg. Adjudin treatment can be well tolerated in rodent. And Adjudin-treated mice show significant tumor growth inhibition compared with the control group (P<0.0001 in the human lung carcinoma cells A549 and P =0.006 in the prostate carcinoma cells PC3).

target

Target	Value
Cl? channel ()
NF-κB ()
ERK ()

Adjudin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Adjudin manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide 252025-52-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

252025-52-8, AdjudinRelated Search:

TSH PIERICIDIN A Testosterone enanthate

1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide

CS-2018

AF-2364

1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide

Adjudin, AF-2364

Adjudin

1-[(2,4-Dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid hydrazide

1-(2,4-Dichloro-benzyl)-1H-indazole-3-carboxylic acid hydrazide

AF-2364;AF 2364;AF2364

1H-Indazole-3-carboxylic acid, 1-[(2,4-dichlorophenyl)methyl]-, hydrazide

1-(2,4-dichlorobenzyl)indazole-3-carbohydrazide USP/EP/BP

AF 2364,Mitochondrial Metabolism,AF2364,Cl? Channels,Adjudin,inhibit,Inhibitor,Chloride Channel

252025-52-8

Inhibitors

pharmaceutical intermedaite