ChemicalBook > CAS DataBase List > 1,3-dipropyl-8-(3-noradamantyl)xanthine

1,3-dipropyl-8-(3-noradamantyl)xanthine

Product Name
1,3-dipropyl-8-(3-noradamantyl)xanthine
CAS No.
136199-02-5
Chemical Name
1,3-dipropyl-8-(3-noradamantyl)xanthine
Synonyms
MK-7418;KW-3902;HMR-4902;Rolofylline;KW-3902 >=98% (HPLC);1,3-dipropyl-8-(3-noradamantyl)xanthine;8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione;8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione;1H-Purine-2,6-dione, 8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-1,3-dipropyl-
CBNumber
CB51337919
Molecular Formula
C20H28N4O2
Formula Weight
356.46
MOL File
136199-02-5.mol
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1,3-dipropyl-8-(3-noradamantyl)xanthine Property

Boiling point:
578.0±42.0 °C(Predicted)
Density 
1.262±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble20mg/mL
form 
solid
pka
9.23±0.70(Predicted)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H413May cause long lasting harmful effects to aquatic life

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
K3769
Product name
KW-3902
Purity
≥98% (HPLC)
Packaging
5mg
Price
$165
Updated
2024/03/01
Sigma-Aldrich
Product number
K3769
Product name
KW-3902
Purity
≥98% (HPLC)
Packaging
25mg
Price
$660
Updated
2024/03/01
Cayman Chemical
Product number
11940
Product name
KW 3902
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
11940
Product name
KW 3902
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
11940
Product name
KW 3902
Purity
≥98%
Packaging
10mg
Price
$199
Updated
2024/03/01
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1,3-dipropyl-8-(3-noradamantyl)xanthine Chemical Properties,Usage,Production

Description

KW 3902 is an antagonist of the adenosine A1 receptor (Ki = 0.19 nM). It displays 890-fold selectivity for A1 receptors over A2A receptors and has no activity at A3 receptors. KW 3902 less potently inhibits human organic anion transporter 1 (OAT1; Ki = 7.82 μM). KW 3902 exhibits renal protective effects during hypoxemia in rabbits.

Uses

KW 3902 is an adenosine A1-receptor antagonist, which has recently been shown to alleviate axonopathy caused by human Tau ΔK280. KW 3902 can be considered for the development of a treatment towards hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases.

Definition

ChEBI: Rolofylline is an oxopurine.

storage

Store at +4°C

1,3-dipropyl-8-(3-noradamantyl)xanthine Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-dipropyl-8-(3-noradamantyl)xanthine Suppliers

China 25 The Netherlands 1 United Kingdom 1 United States 11 Global 38
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136199-02-5, 1,3-dipropyl-8-(3-noradamantyl)xanthineRelated Search:

N,N-Dimethyl-1-adamantylamine

  • 1,3-dipropyl-8-(3-noradamantyl)xanthine
  • HMR-4902
  • KW-3902
  • Rolofylline
  • 8-(Hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,7-dihydro-1,3-dipropyl-1H-purine-2,6-dione
  • MK-7418
  • 8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipropyl-3,7-dihydro-purine-2,6-dione
  • 1H-Purine-2,6-dione, 8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-3,9-dihydro-1,3-dipropyl-
  • KW-3902 >=98% (HPLC)
  • 136199-02-5